BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Known as:
- BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Catalog number:
- 15040P-60
- Product Quantity:
- 12
- Category:
- -
- Supplier:
- Kimb
- Gene target:
- BOTTLE DROPPING AMB PLAS DROPPER 60ML
Related genes to: BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Gene:
- LCP1 NIH gene
- Name:
- lymphocyte cytosolic protein 1
- Previous symbol:
- -
- Synonyms:
- PLS2, CP64, L-PLASTIN, LC64P
- Chromosome:
- 13q14.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
1 x 175-225ml Bottle Adapters For 250ml Round Buckets1 x 400ml Bottle Adapters For 500ml Rectangular Buckets1-Drop PCR Mix (squeeze bottle, no pipet)1-Drop PCR Mix (squeeze bottle, no pipet)1-Drop PCR Mix (squeeze bottle, no pipet)1000ml Square Media bottle for Media serum bottling or casual uses 12/tray Sterile to SAL 10-61000ml Square Media bottle for Media, serum bottling or casual uses 12_tray, Sterile to SAL 10-6, 24_case1000ml Square Media bottle for Media, serum bottling or casual uses 12_tray, Sterile to SAL 10-6, 24_case box size(mm):310x400x465100ml bottle for C0320-720 insert, ea.100ml bottle for C0320-720 insert, ea.100ml bottle for C0320-720 insert, ea.10X Plate Wash Buffer, 125 ml bottle125ml Square Media bottle for Media serum bottling or casual uses 24/tray Sterile to SAL 10-6125ml Square Media bottle for Media, serum bottling or casual uses, 24_tray, Sterile to SAL 10-6, 96_case125ml Square Media bottle for Media, serum bottling or casual uses, 24_tray, Sterile to SAL 10-6, 96_case box size(mm):240x335x465 Related articles to: BOTTLE,DROPPING,AMB,PLAS DROPPER,60ML
- Bovine leukemia virus (BLV) is an oncogenic retrovirus that naturally infects cattle. Once infected, the virus persists indefinitely throughout life at a transcriptionally silent stage. Soon after infection, humoral and cytotoxic activities efficiently abolish the viral replicative cycle, allowing only mitotic expansion of provirus-carrying cells. These anti-viral activities persist throughout the animal's life indicating that the immune system is permanently stimulated by BLV antigens. Although protein production is abolished during the chronic stage, viral transcription is not completely shut down. Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released from most cells and play multiple roles in cell-to-cell communication, including immune modulation, angiogenesis, and transformation of cells by transferring genetic material and functional proteins. Colostrum is rich in EVs that carry bioactive proteins and RNAs reflecting maternal physiology and immune status. In this study, we aimed to characterize how BLV infection influences the protein cargo of colostrum-derived EVs. - Source: PubMed
Publication date: 2026/07/29
Pérez Cecilia ValeriaCarignano Hugo AdriánMarchetti Yamila CelesteGonzález Diego DanielRuiz VanesaTrono Karina GabrielaMongini Claudia - Early onset preeclampsia (EOPE), a complex complication of pregnancy, is a major contributor to maternal and fetal morbidity and mortality. The only symptom consistently observed in EOPE is new maternal hypertension. Other symptoms vary among patients, posing challenges for early detection. There are currently no clinically accepted molecular markers other than FLT1, which is highly upregulated and displays a small change in its splicing ratio in EOPE placentas. However, an exhaustive search for changes in transcript use in EOPE has not been performed. - Source: PubMed
Publication date: 2026/07/17
Grinshpan NufarMizrachi TehilaLianski SapirZarivach RazGoldman-Wohl DebraBeharier OferShay Tal - Stroke remains a leading cause of death and long-term disability worldwide. After reperfusion following ischemic stroke, peripheral immune cells infiltrate the injured brain hemisphere and exacerbate secondary damage. Among these cells, monocytes are among the predominant population. In this study, we performed single-cell RNA sequencing of immune cells isolated from the brain 72 h after infarction and characterized the heterogeneity of brain infiltrating monocyte-derived macrophages. We identified an IL7R macrophage subset with high fatty-acid metabolism scores 3 days after ischemic stroke in mice. In vitro oxygen glucose deprivation cell model, Il7r expression was significantly increased, accompanied by upregulation of the PI3K-AKT pathway. IL7R knockdown decreased phosphorylated Akt and LCP1 levels, and LCP1 knockdown further reduced arachidonic acid, a key mediator of pro-inflammatory protein translation, as revealed by bulk RNA-seq and metabolomics analyses. Consistent with these in vitro results, IL7R depleted mice exhibited smaller infarct volumes and improved neurological function. Collectively, our findings provide mechanistic insight into how IL7R-pAKT-LCP1 signaling shapes immune-cell metabolism during stroke-induced neuroinflammation and suggest potential therapeutic opportunities targeting immunometabolic pathways in ischemic stroke. - Source: PubMed
Publication date: 2026/07/14
Yin QianqianChen ShaomengYang DecaoLi RuoxiHang HangXu ChanWang XiaoyueLi JinxinZhao JingyiWang JianingChen JiaxinSun PanxiZhang TingtingHu QianxueXu JiaxingXue LixiangLiu CuiyingHuang ShengZhao HengWang Yan - Reducing dietary crude protein (CP) in nursery pig diets is a strategy to decrease post-weaning diarrhea (PWD), optimize feed costs, and reduce nitrogen excretion. One way by which high CP (HCP) diets increase PWD involve potentially cytotoxic proteolytic fermentation metabolites produced in the hindgut from unabsorbed proteins. Increasing dietary fiber fermentability with carbohydrase inclusion may mitigate this modality by shifting microbial fermentation towards carbohydrate substrate. To evaluate these interactions, a 3 × 2 factorial design assessed pig performance, nitrogen retention, hindgut fermentation, and health outcomes using high- and low- CP diets with or without a non-starch polysaccharidase (NSPase; xylanase). A total of 792 newly weaned 17 to 22- d-old mixed sex pigs (6.2 ± 0.12 kg body weight [BW]) were randomly allotted to three CP diets with or without NSPase ( = 12 pens/treatment), fed in three phases (10, 11, and 21 d). The CP and Lys per diet and phase were: (1) 16% CP containing 1.20, 1.15, and 1.10% standardized ileal digestible (SID) Lys per phase (LCP1.2); (2) 17% CP containing 1.40, 1.35, and 1.30% SID Lys (LCP1.4); (3) 24% CP containing 1.40, 1.35, and 1.30% SID Lys (HCP1.4). On d 10, one barrow per pen ( = 12 pigs/treatment) was moved to metabolism crates and fed at ∼5% of their average BW for 7 d on phase 2 diets, after which total fecal, and urine output were collected over a 4-d period for nitrogen retention analysis. On d 21, pigs utilized for metabolism evaluation were euthanized to collect intestinal tissue and luminal contents. The highest overall average daily gain and feed efficiency were observed in pigs fed HCP1.4 (both < 0.0001). During phase 1, a tendency for a diet × NSPase interaction on PWD incidence was observed ( = 0.063), as NSPase numerically decreased incidence in HCP1.4 pigs but increased it in LCP1.4 and LCP1.2 pigs; overall, HCP1.4 pigs had greater PWD incidence than LCP1.4 and LCP1.2 pigs ( < 0.045). Pigs fed HCP1.4 diets observed increased nitrogen excretion and retention (g/d) when compared pigs fed either LCP diet (both < 0.001, respectively). Pigs fed HCP1.4 had the highest production of total volatile fatty acids (VFA, = 0.027). Polyamines cadaverine and putrescine were unaffected by CP ( > 0.05), but NSPase tended to reduce cadaverine production in all pigs ( = 0.079). Herein, pigs fed HCP diets observed improved performance concurrently with increased nitrogen excretion and PWD incidence. - Source: PubMed
Publication date: 2026/07/02
Nisley Mitchell JKerr Brian JPearce Sarah CSparks ChrisGabler Nicholas K - Komagataella phaffii is one of the most widely used eukaryotic protein expression systems. Increasing the copy number of exogenous genes is a common method to enhance expression efficiency. However, at extremely high copy numbers, the resulting endoplasmic reticulum stress (ERS) can hinder further improvement in the expression efficiency of secreted proteins. And elucidating the underlying molecular mechanisms serves as the foundation for engineering and constructing stress-adapted strains. High-copy secretory expression was first confirmed to adversely affect yeast growth fitness, a phenotype consistent with DTT-induced unfolded protein response (UPR). Screening of a kinase knockout library established that UPR signalling in K. phaffii was modulated by the PpHog1-mediated MAPK pathway. PpHog1, the K. phaffii ortholog of the well-characterized Saccharomyces cerevisiae Hog1 (67% sequence identity), is traditionally known for its roles in osmotic stress and cell wall integrity. Notably, while ScHog1 has also been implicated in ERS regulation, the downstream pathway remains obscure. Further comparison of the PpHog1 interactome with versus without DTT treatment, combined with follow-up genetic knockout/knockdown screens, leads to the identification of two critical UPR regulators: PpLRR-0498 and PpPINT-0120. Subsequently, an engineered UPR-adaptive chassis (UPR-Ad) was constructed by over-expressing these three key regulators. Using human serum albumin (HSA), human calcium-regulated actin binding protein LCP1, and α-amylase as reporters, UPR-Ad enhanced the production of high-copy secretory proteins by 30%-46%. Collectively, this work advances the understanding of UPR regulation in K. phaffii and provides a strategic basis for designing high-yield strains. - Source: PubMed
Shi JiachengLv ZhanqingLu ChaoyuFang BohaoZou ZeruiZhou Mian