SYNTHETIC HUMAN DECORIN, Product Type Purified Protein, Specificity DECORIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone
- Known as:
- SYNTHETIC HUMAN DECORIN, Product Type Purified Protein, Specificity DECORIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone
- Catalog number:
- 7870-6200
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- AbD
- Gene target:
- SYNTHETIC HUMAN DECORIN Product Type Purified Protein Specificity Target Species Human Host N_A Format Isotypes Applications Clone
Related genes to: SYNTHETIC HUMAN DECORIN, Product Type Purified Protein, Specificity DECORIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone
- Gene:
- JAK3 NIH gene
- Name:
- Janus kinase 3
- Previous symbol:
- -
- Synonyms:
- L-JAK, JAKL, LJAK, JAK3_HUMAN, JAK-3
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-19
- Date modifiied:
- 2019-04-23
Related products to: SYNTHETIC HUMAN DECORIN, Product Type Purified Protein, Specificity DECORIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone
Related articles to: SYNTHETIC HUMAN DECORIN, Product Type Purified Protein, Specificity DECORIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone
- - Source: PubMed
Publication date: 2026/09/25
King BrettSoung JenniferTziotzios ChristosRudnicka LidiaJoly PascalGooderham MelindaSinclair RodneyMesinkovska Natasha APaul CarleGong YankunAnway Susan DTran HelenWolk RobertZwillich Samuel HLejeune Alexandre - JAK3 is a non-receptor tyrosine kinase that plays an important role in immune signaling pathways. It has long been indicated as a potential target for autoimmune diseases. In this work, a set of 28 novel JAK3 inhibitors were designed around a thieno[3,2-d]pyrimidine core, with aromatic moieties at the 2-position, and a range of alkyl linkers connected to electrophillic groups at the 4-position. Structure-based design has been employed in an attempt to maximize activity through direct reaction of the inhibitor electrophile and Cys909 residue located within the JAK3 active site. We identified the acrylamide containing compound 42 as a potent inhibitor of JAK3, with an IC of 6.2 nM and selectivity of 23.4-fold over the related JAK2 enzyme. This compares to 1.4 nM and 53.1-fold, respectively, for the 1st generation JAK3 inhibitor Tofacitinib. 42 also demonstrated good selectivity against 10 diverse kinases at a screening concentration of 1 μM, a low logD of 1.51 and good phosphate buffer solubility (1030.8 μg/ml). Computational analysis was undertaken to help rationalize the SAR in the form of molecular dynamics simulations and quantum chemical cluster calculations of electrophile-nucleophile reactivity. - Source: PubMed
Publication date: 2026/09/12
Fukasem PoowadonJaengwang KittitatGleeson DuangkamolBritton Robert GChoowongkomon KiattaweeGleeson M Paul - Phospholipase C (PLC)-evoked rising intracellular Ca2+-levels are a prerequisite for platelet activation with subsequent thrombosis. The protein-tyrosine kinase Janus kinase 3 (JAK3) regulates phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-levels in platelets, thus significantly mediating activation-dependent platelet function and arterial thrombosis. - Source: PubMed
Publication date: 2026/09/21
Münzer PatrickKollotzek FerdinandManke Mailin-ChristinFindik BetülMott KristinaFischer MelinaLingens Gundula DZdanyte MonikaStein FredericGeue SaschaWalker BrittaGawaz MeinradGeisler TobiasRath DominikAhrends RobertLämmerhofer MichaelSchulze HaraldSkokowa JuliaBorst Oliver - The chronic failure of psoriasis treatment strongly recommends a tailored biocompatible therapeutic platform considering the immunological and inflammatory factors of psoriasis pathogenesis. This strategy recommends the utilization of natural phytomolecule of piceatannol due to its healing cutaneous potential, mesenchymal Stem cell-derived exosomes as a regenerative natural nanocarriers and a hydrogel facilitating prolonged release. This work aimed to augment the anti-psoriatic pattern of piceatannol utilizing the mesenchymal stem cells derived exosomes via topical delivery to imiquimod-induced psoriatic mice skin. The formulated exosomal piceatannol platforms were assayed for particle size analysis, entrapment efficiency, flow cytometry analysis, functional size of 137.6 nm, zeta potential of -61.4 ± 6.04 mV, PDI of 0.331, >97% positive expression of all the three tetraspanin markers (CD9, CD63, CD81), entrapment efficiency of 32.8 ± 1.7%, prolonged cumulative release reaching 37.5% after 72 h and satisfactory characterization of 2% w/w carboxymethylcellulose hydrogel. In vivo experimental estimation of the anti-psoriatic activity was conducted and supported by molecular analysis of IL-17, TNF-α, and pSTAT3 levels. mRNA expression of JAK3 was analyzed to explore the targeting of Janus kinase/STAT3. The findings revealed the promising anti-psoriatic activity of the exosomal piceatannol, supported by molecular potential in reducing the mentioned cytokine levels, targeting of JAK/STAT3 pathway and histopathological healing pattern in the psoriasis-induced skin. In conclusion, piceatannol was successfully shown to have a promising regenerative anti-psoriatic profile when loaded as an exosomal hydrogel. - Source: PubMed
Publication date: 2026/09/18
Al-Sawahli MajidAl-Zurfi Atheer Mohammed JasimHussein Ameen Ayad AAbdallah Ahmed NAlamoudi Jawaher AbdullahSaleh AsmaaEl-Telbany RaniaSalahuddin AhmadAlfaifi Mohammad YShati Ali AElbehairi Serag Eldin IKassem Amira BGalal Asmaa FKishta Mohamed SAlamri Zaenah ZuhairZakaria SherinNoreddin Ayman MEl-Telbany Dalia Farag AAbass Shimaa A - Rosacea is a chronic inflammatory skin disorder characterized by neurovascular instability and dysregulated innate immunity. Although mast-cell activation is increasingly recognized as a central pathogenic feature, the neuroimmune mechanisms linking neuropeptide signaling to mast cell-mediated inflammation remain incompletely defined. This study investigated whether calcitonin gene-related peptide (CGRP) promotes mast cell-mediated inflammation in rosacea and explored the underlying signaling mechanism. - Source: PubMed
Publication date: 2026/09/02
Li XiaojinFan HuipingSun RuiMa QingsongLiu JiayunLiu ChengqiZhang DongMa Weiyuan