KITLG _ SCF
- Known as:
- KITLG _ SCF
- Catalog number:
- GTX29717
- Product Quantity:
- 10 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- KITLG _ SCF
Related genes to: KITLG _ SCF
- Gene:
- KITLG NIH gene
- Name:
- KIT ligand
- Previous symbol:
- MGF
- Synonyms:
- SCF, SF, Kitl, KL-1, FPH2, SLF, DFNA69
- Chromosome:
- 12q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-04
- Date modifiied:
- 2019-04-23
Related products to: KITLG _ SCF
Related articles to: KITLG _ SCF
- Pregnancy elicits extensive remodeling of the mammary gland to establish the alveolar network required for lactation, yet the cellular programs underlying this transition in pigs remain poorly resolved. Here, we generated a single-cell transcriptomic atlas of the porcine mammary gland across gilt, late pregnancy, and post-lactational stages. Differential expression analyses identified epithelial, fibroblast and endothelial compartments as the most dynamic during pregnancy, motivating higher-resolution analyses of these lineages. Epithelial trajectories toward alveolar fate exhibited induction of fibrillar collagen programs, including , and , implicating epithelial contributions to extracellular matrix assembly. Fibroblast analysis revealed a PGLYRP1 fibroblast subtype enriched for the chemokines , and , suggesting a role in immune cell recruitment. Endothelial cells undergo stage-specific metabolic reprogramming, with late pregnancy characterized by increased expression of glycolysis-associated genes, including , and , as well as lipid metabolism-related genes such as , and . Cross-species comparison revealed conserved cellular identities and key molecular features ( , , ) across human, pig, and mouse mammary glands. Together, this atlas delineates the cellular logic underlying pregnancy-associated remodeling and serves as a resource for elucidating transcriptomic changes in the porcine mammary gland. - Source: PubMed
Yang Si-YuYao Tian-XiongHuang Lu-Sheng - This study aimed to develop a mitochondrial and hematopoiesis-related differentially expressed genes (MH-related DEGs) signature for Myelodysplastic syndromes (MDS) diagnosis and to characterize its regulatory network and immune microenvironment. - Source: PubMed
Publication date: 2026/09/02
Liu XianchuanZhang HongLi Xiangzhu - Chronic exposure to the widely used organophosphate pesticide chlorpyrifos has been associated with reproductive dysfunction; however, the early subclinical events preceding overt reproductive dysfunction remain poorly understood due to cell-specific and non-monotonic responses to the toxicant. The present study investigated the effect of chronic CPF exposure on the spermatogenic niche and sperm epigenome in a mouse model. Despite the absence of detectable oxidative stress or reproductive toxicity, chronic CPF exposure induced significant changes in the testicular microenvironment. Testicular proteomic analysis revealed dysregulated expression of proteins involved in extracellular matrix remodeling in CPF-exposed mice. These changes were associated with increased expression of Ctnnb1 and Axin1 indicating modulation of β-catenin-associated signaling in the testis. Furthermore, CPF exposure was associated with dysregulation of Sertoli cell function characterized by a significant reduction in Kitlg expression, increased c-kit levels, and reduced expression of the gap junction protein Connexin 43. CPF exposure also led to a significant dose-dependent increase in the expression of Tet1 suggesting altered epigenetic regulation in the testis. Interestingly, there was a trend toward increased sperm DNA methylation in CPF-exposed mice. Overall, these findings reveal that chronic CPF exposure induces early remodeling of the spermatogenic niche and alters testicular epigenetic regulation prior to overt reproductive dysfunction, identifying the Sertoli cell-extracellular matrix axis as a potential early target underlying CPF-induced testicular toxicity. - Source: PubMed
Publication date: 2026/08/20
Mansukhani MeenakshiTasneem RuqaiyaSen Sharma Souvik - MicroRNAs regulate gene expression post-transcriptionally, yet target prediction faces a credibility gap: published methods drop sharply against CLIP-seq-validated negatives. We present DeepExoMir, a deep learning framework integrating frozen RiNALMo RNA language model embeddings with biologically informed features. Under a dual-probe ablation protocol on three miRBench test sets, DeepExoMir reaches mean AU-PRC 0.855, surpassing eight retrained baselines (paired bootstrap p<0.001). Evolutionary conservation and duplex structure prove largely redundant with language-model priors, motivating a structure-free Lite variant (0.863). On nine exosomal miRNAs from a companion melanogenesis study, DeepExoMir recovers literature-validated targets and ranks canonical pigmentation regulators (KITLG, MITF, TYRP1) in the top 5%. - Source: PubMed
Publication date: 2026/07/10
Lin Wen-HsienHsiung Chia-NiLien Wen-YuSieber Martin - Cryptorchidism, a major reproductive malformation in dogs, is associated with an increased risk of testicular cancer. In this study, we aimed to compare miRNA expression and 3'UTR length variation in the mRNAs of differentially expressed genes (DEGs) between undescended (UD) and descended (D) canine testes without signs of tumorigenesis. In total, expression of 453 miRNA genes was detected, and over 100 miRNA DEGs were identified in the UD vs. D and UD vs. C (control) comparisons. Predicted target sequences for DEG miRNAs were in silico identified in numerous mRNAs, including 12 of 19 a priori selected genes related to testicular cancer. In silico analysis of miRNA and mRNA DEGs revealed that some of target mRNAs showed significant differences in UD and D/C testes and approximately 50% of miRNA-mRNA pairs exhibited an inverse expression pattern, including cancer-related genes (e.g., AR, IGF1R, KIT, KITLG, SALL4, and SPRY4). Analysis of the 3'UTR length of DEG mRNAs identified 962 transcripts with altered 3'UTR length in both the UD vs. D and UD vs. C comparisons. 3'UTR lengthening (e.g., in cancer-related genes such as LATS2, SRPK2, and AKT3) was the most common alteration observed. Our findings provide a new insight into molecular alterations associated with canine cryptorchidism. We suggest that in undescended canine testes without signs of tumorigenesis dysregulated expression of protein-coding genes, including candidate cancer-associated genes, can be associated with altered expression of specific miRNAs, as well as variations in the 3'UTR length of certain target DEG mRNAs. - Source: PubMed
Publication date: 2026/07/06
Nowacka-Woszuk JoannaKajdasz ArkadiuszStachowiak MonikaSzczerbal IzabelaSwitonski Marek