CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- GTX21088
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Allogeneic transplantation is a cornerstone treatment for hematologic malignancies and organ failure, yet its success is limited by graft-versus-host disease (GvHD) and allograft rejection. Conventional broad-spectrum immunosuppression compromises protective graft-versus-leukemia (GvL) effects and anti-infectious immunity, creating an urgent need for precision tolerance strategies. CD4Foxp3 regulatory T cell (Treg)-directed strategies offer a promising solution but expanding stable, functional Tregs ex vivo and in vivo remains challenging. Given the pivotal role of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF) in Treg biology, this review aims to critically examine how its members control Treg function and how these pathways can be leveraged for Treg‑based therapies. We systematically analyze key TNFRSF members - TNFR2, OX40, CD40, Fas, CD27, 4-1BB, GITR, and DR3 - detailing their dichotomous roles in Treg function and translational potential. We highlight how agonism of TNFR2 or DR3 offers selective Treg expansion while preserving GvL activity, and how CD27 and 4-1BB serve as valuable markers for isolating highly suppressive Treg subsets. We further discuss translational challenges, including the paradoxical effects of OX40 and GITR, which can either enhance or impair Treg function depending on the inflammatory milieu, and the vulnerability of Tregs to Fas-mediated apoptosis during ex vivo expansion. We also discuss CD40-CD40L blockade as a complementary strategy to empower endogenous Tregs. By synthesizing current knowledge, this review provides a rational roadmap for using selective agonism, blockade, or phenotypic selection to bolster Treg‑based therapies for GvHD, offering practical information for both laboratory and clinical efforts to optimize Treg manufacturing and achieve durable tolerance. - Source: PubMed
Publication date: 2026/06/06
Chou Chon-KitWang XinyangYu RuiqiXu HangChen YiboYang YangChen ZhonghaoLi ChuangenHe TianzhenChen Xin - Functionality appreciation, valuing the body for what it can do, is a central aspect of positive body image. The Functionality Appreciation Scale (FAS) is widely used to assess this construct; however, its item-level properties have not been examined using item response theory. This study applied a graded response model to evaluate item discrimination, difficulty, and measurement precision, and to assess differential item functioning across gender. Participants were 386 adults aged 18-39 (M = 27.54, SD = 5.58) from English-speaking countries. Confirmatory factor analysis supported a unidimensional FAS structure. Graded response model analyses indicated strong item discrimination (α = 2.79-4.08) and appropriate difficulty thresholds, with items varying in sensitivity across levels of functionality appreciation. Test information functions demonstrated optimal precision in the moderate range (approximately -2 to +1 SD), with lower precision at extreme levels of the latent trait. Differential item functioning analyses revealed no significant gender differences, supporting measurement invariance across gender. These findings provide detailed item-level evidence supporting the reliability and utility of the FAS in community samples. Highly discriminating items may be especially sensitive to differences in functionality appreciation; however, caution is warranted when interpreting scores at the extremes of the latent trait, particularly in non-clinical samples. Future research should examine FAS performance across broader demographic, cultural, and clinical populations and explore refinements to improve measurement precision at extreme trait levels. Overall, the FAS appears to be a robust and informative measure of functionality appreciation. These findings further support its application within positive body image and well-being research. - Source: PubMed
Publication date: 2026/06/05
Marmara Joshua AZarate Daniel - The epidemiology of Foix-Alajouanine syndrome (FAS) remains poorly characterized. Accurate data on the prevalence of FAS In Russia are not available; in Germany, only 5-10 cases per 1 million population are reported. The article reviews data from the current literature on FAS and presents a clinical case of a patient with a dural arteriovenous fistula at the level of the craniovertebral junction with severe circulatory disorders at the upper cervical level of the spinal cord, with progressive severe focal neurological deficit, despite endovascular surgery. The disease-associated syndromes are described in detail, including the chronic critical condition, as well as the rehabilitation approach for this patient. The indications for surgery and choosing a treatment method for this patient, considering an extremely high risk of irreversible spinal circulatory disorders, were debatable. - Source: PubMed
Kukanova O MLesteva N ALesina S SKozlyakov A VSebelev K IIvanov A APetrov A EToporkova O AKondratiev A NSamochernyh K A - To identify the clinical features associated with chronic pain and the premorbid factors in patients with metabolic syndrome of various phenotypes. - Source: PubMed
Vorob'eva O VGertsog A AAshikhmin G MMorozova T E - Academic anesthesiology department chairs face significant responsibilities, yet formal leadership pathways remain unclear. The purpose of this study was to characterize the educational backgrounds and career trajectories of current U.S. anesthesiology department chairs. Chair information was sought for all 192 Accreditation Council for Graduate Medical Education-accredited anesthesiology residency programs. During data collection, 40 were excluded due to absence of a designated chair or insufficient publicly available information, yielding a final sample of 152 chairs. The most common medical schools that the chairs attended were the University of Washington, the University of Chicago, and Johns Hopkins University (each, n = 4; 2.6%). Massachusetts General Hospital was the most frequent residency site (13/149; 8.7%) and fellowship site (9/84, 10.7%). Median time from residency to chair appointment was 21 yr (interquartile range [IQR], 15 to 27) and median tenure was 5 yr (IQR, 3 to 9). Most chairs had modest to moderate scholarship (Hirsch Index: 1 to 15 in 54.1%) with a median of 14 (IQR, 4 to 34). These findings suggest pathways to chair are frequently diverse, often non-research-intensive, and support the imperative for structured leadership development. - Source: PubMed
Publication date: 2026/06/01
Estright Alexander WPruitt Kyle APope Samantha EChilders MaxwellClark Sean CSingh ManinderAlter Jonathan AHill Hannah ETollinche Luis E