CAMK2A
- Known as:
- CAMK2A
- Catalog number:
- GTX19223
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CAMK2A
Related genes to: CAMK2A
- Gene:
- CAMK2A NIH gene
- Name:
- calcium/calmodulin dependent protein kinase II alpha
- Previous symbol:
- CAMKA
- Synonyms:
- KIAA0968, CaMKIINalpha
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2016-04-06
Related products to: CAMK2A
Related articles to: CAMK2A
- β-Amyloid precursor protein (APP), an amyloid β-peptide (Aβ) generating protein, plays a central role in Alzheimer's disease (AD). Its intracellular trafficking and proteolytic processing are precisely regulated, but the mechanisms remain elusive. Here, we identified LAMTOR1 as a novel APP intracellular domain binding partner that sorts APP from early endosomes to late endosomes. Knockout of LAMTOR1 decreased APP trafficking to late endosomes, which promoted its amyloidogenic processing on early endosomes, resulting in increased Aβ. Conditional knockout of LAMTOR1 in Camk2a-expressing neurons impaired memory function in AD mouse model. Furthermore, the targeting of APP to late endosomes is mediated by adaptor protein complex 3 (AP-3). AP-3 bound to LAMTOR1, and its depletion caused accumulation of LAMTOR1 and APP within early endosomes, subsequently increasing Aβ. Thus, LAMTOR1 functions as a regulator of APP trafficking to late endosomes and may serve as a potential therapeutic target for AD. - Source: PubMed
Publication date: 2026/08/26
Zhou ChenqianCao WenyuanCong RixuShan ChunyanTian YongluXu SizhengFeng WeiranLi YuanjunWang XunTeng JunlinZheng PengliHuang NingChen Jianguo - Acute myeloid leukemia (AML) exhibits heterogeneous outcomes and lacks reliable prognostic markers. As a critical regulator of cell fate, calcium signaling's prognostic value in AML requires investigation. This study aims to construct a calcium-related gene (CRG)-based prognostic model for AML. Differential analysis on RNA-seq data was conducted for AML from TCGA and GEO. Intersecting differentially expressed genes and CRGs yielded AML-associated differentially expressed CRGs (DECRGs). A prognostic model was developed through univariate/multivariate Cox regression and LASSO, and validated in a GEO dataset. Bioinformatics analyses explored the links between risk groups and immune characteristics, genomic mutations, and drug sensitivity. Key genes' effects on cell proliferation, apoptosis, and differentiation were verified in vitro using CCK-8 assay, colony formation assay, and flow cytometry. The 13-DECRG-based model distinguished high- and low-risk patients in both training and validation cohorts, with high-risk patients showing a worse prognosis. The risk score was an independent prognostic factor. Immune analysis revealed a unique immune microenvironment for the high-risk group. CAMK2A overexpression inhibited cell proliferation and colony-forming ability, promoted cell apoptosis, and induced an increased proportion of CD11b- and CD14-positive cells. In vitro experiments indicated CAMK2A-induced suppression of AML cells' malignant phenotype by activating the P53 signaling pathway. An AML CRG-based model with favorable risk stratification performance was constructed. In vitro experiments revealed CAMK2A-induced inhibition of the malignant phenotype via suppressing proliferation, promoting apoptosis, and facilitating myeloid differentiation in AML cells. This study provides novel evidence for understanding CRGs in AML as well as the potential functions of CAMK2A. - Source: PubMed
Publication date: 2026/08/25
Duan JingZhang HuChu JunjieDuan Xiangdong - Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba is a traditional Tibetan medicine that has long been used in China for its cardioprotective, Qi-tonifying, and mind-calming properties. It is traditionally indicated for conditions such as irritability, restlessness, and agitation. Among its major active constituents are two naturally occurring small-molecule phenols-salidroside (SAL) and its aglycone tyrosol (TYR). While SAL has been reported to exert neuropsychiatric effects including anxiolytic activity, the underlying mechanisms remain incompletely understood, and whether TYR shares similar anxiolytic properties has yet to be clarified. - Source: PubMed
Publication date: 2026/08/19
Cui JunboJia ChunxueWang ZixinSun YuhanLiang YuluLiu ChuanxinHuang Jianmei - The excessive hierarchical follicles (EHF) trait is a form of ovarian dysfunction in poultry, characterized by an accumulation of hierarchical follicles; however, the developmental dynamics and epigenetic mechanisms underlying this trait remain incompletely understood. In this study, ultrasonography was applied to monitor follicle development dynamics in chickens. Furthermore, whole-genome bisulfite sequencing was performed to identify DNA methylation alterations in the granulosa layer relevant to the EHF trait. During the early laying period, the EHF trait exhibited a fluctuating downward trend and was associated with impaired egg production. DNA methylation occurred predominantly in the CG context and displayed a pattern of promoter hypomethylation and genebody hypermethylation. In EHF chickens, more pronounced hypomethylation was detected in CpG islands, promoters, 5'UTRs, and exons in the small yellow follicle granulosa layer (SYG). Several genes overlapping promoter-related differentially methylated regions were significantly enriched in pathways such as Wnt signaling, Calcium signaling, and Focal adhesion. Among these genes, AKT1, PIK3CA, FZD2, CAMK2A, and RYR2 exhibited significant promoter hypomethylation together with increased mRNA expression. In summary, this study suggests that region-specific promoter hypomethylation in SYG may contribute to EHF development. These findings enhance understanding of the epigenetic regulation of the EHF trait and may support efforts in laying management. - Source: PubMed
Publication date: 2026/05/22
Xu ZihanPan YanyueZhu RanranJiang YuxiangLian ZiyiZhang BingjieTang HaonanXiong WanyiWang XiupingWang JiankuiDeng Xuemei - Colorectal cancer (CRC) remains a leading cause of cancer mortality, and the molecular drivers of progression and distant metastasis are incompletely understood. By integrating differential expression and survival analyses of TCGA CRC cohorts with HOX family genes, we identified HOXC11 as a key metastasis-associated factor. HOXC11 was markedly upregulated in CRC tissues and cell lines, with higher expression in metastatic lesions than in primary tumors, and elevated HOXC11 correlated with poor patient prognosis. HOXC11 functionally increased CRC cell proliferation, migration, and invasion in vitro and facilitated tumor growth and metastasis in vivo. Mechanistically, HOXC11 directly bound to the CAMK2A promoter and transactivated CAMK2A, leading to increased phosphorylated CAMK2A and initiation of the NF-κB pathway, which facilitated p65 nuclear translocation and induced CXCL5 expression to drive CRC progression. Conversely, CXCL5 signaling through CXCR2 upregulated HOXC11 via the ERK1/2-SP1 axis, forming a positive feedback loop. Notably, combined inhibition of CAMK2A (KN-93) and CXCR2 (SB265610) significantly attenuated HOXC11-mediated proliferation and metastasis. Collectively, these findings define a HOXC11-CAMK2A-NF-κB-CXCL5 circuit as a potential therapeutic target in CRC. - Source: PubMed
Publication date: 2026/08/19
Sun QingyangXu HengjieYang ShengZhou JiahuiTian ChuanxinNie HongxuJin ChiWang TuoChen ZhihaoTang JunweiFeng YifeiWang XiaoweiSun Yueming