IL21
- Known as:
- IL21
- Catalog number:
- GTX18495
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- IL21
Related genes to: IL21
- Gene:
- IL21 NIH gene
- Name:
- interleukin 21
- Previous symbol:
- -
- Synonyms:
- Za11, IL-21
- Chromosome:
- 4q27
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-29
- Date modifiied:
- 2019-04-23
Related products to: IL21
Related articles to: IL21
- Interleukin-21 (IL-21) is a pro-inflammatory cytokine involved in the regulation of both innate and adaptive immune responses and has been associated with atherosclerotic cardiovascular disease (ASCVD). However, the exact role of IL-21/IL-21R signaling in atherosclerosis and the therapeutic potential of targeting this axis remain unclear. - Source: PubMed
Publication date: 2026/09/03
Snijckers Roy P MSmit VirginiaPostel Rimke JDepuydt Marie A CBernabé Kleijn Mireia N ABot Ilzede Mol JillFoks Amanda C - - Source: PubMed
Steffin DavidCourtney Amy NChoe MichelleGhatwai NishaEsparza Cerda Magdalena ASweidan RamyDhanashree RajdekarZhang HuiminLapteva NatashaMei ZhuyongGrilley Bambi JMetelitsa Leonid SHeslop Helen EBrenner Malcolm KHeczey Andras - Cytokines used during chimeric antigen receptor (CAR) T-cell manufacturing can influence product differentiation and functional fitness. - Source: PubMed
Publication date: 2026/08/25
Val-Casals MariaAltuna AnePérez-Amill LorenaArmand-Ugón MercedesPeña SergioLópez-Pecino AnaColomer DolorsEsteve JordiJuan ManelKlein-González Nela - Chronic periodontitis (CP) is an inflammatory-destructive disease, and Th17 cells play a vital role in driving and regulating CP. This study aimed to confirm the influence of miR-3917/HLA-DRB1 in the differentiation of CD4 T cells to Th17 cells. The differentially expressed microRNAs (miRNAs) in CP were screened from the Gene Expression Omnibus (GEO) database, and then the target gene of miR-3917 was confirmed by using the RT-qPCR and Dual-Luciferase assay. clinical data of patients with CP and healthy individuals were collected, and intergroup comparisons were performed using ROC and logistic regression analysis. A CD4T cell differentiation model was established to explore the role of the miR-3917/HLA-DRB1 axis in regulating CD4T cell differentiation into Th17 cells. STAT3 and RORγt levels were detected by RT-qPCR and WB. Production of IL-17 and IL-21 was determined by ELISA kits. MiR-3917 upregulation and HLA-DRB1 downregulation were detected in patients with CP. Overexpression of miR-3917 promoted the differentiation of CD4T cells toward Th17 cells, boosted the secretion of IL-17 and IL-21, and elevated the levels of STAT3 and RORγt, whereas inhibition of miR-3917 exerted the opposite effects. Rescue experiment confirmed that miR-3917 increased Th17 cell differentiation by directly targeting and regulating HLA-DRB1. MiR-3917 downregulated HLA-DRB1, thereby promoting Th17 cell differentiation and ultimately aggravating inflammation. These findings suggested that miR-3917 may be involved in CP pathogenesis and might serve as a potential diagnostic biomarker for CP. - Source: PubMed
Publication date: 2026/09/08
OuYang YuLuLi QiyanXie HuiminZhang TingtingDai Zhenhua - The functional status of regulatory T cells expressing the gut-homing receptor CCR9 (CCR9 Tregs) in type 1 diabetes mellitus (T1DM) remains unclear. This study aims to investigate the functional alterations of CCR9 Tregs in a T1DM model and evaluate the interventional effect of targeting the IL-21/IL-17 axis on their dysfunction. - Source: PubMed
Publication date: 2026/08/30
Xia YulianHe QingYao YuhuiYang LeiZhan ShanshanMao Shunfeng