SOX9 Antibody (monoclonal) (M04)
- Known as:
- SOX9 Antibody (mab) (M04)
- Catalog number:
- AT4002a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- SOX9 Antibody (monoclonal) (M04)
Related genes to: SOX9 Antibody (monoclonal) (M04)
- Gene:
- ARHGAP15 NIH gene
- Name:
- Rho GTPase activating protein 15
- Previous symbol:
- -
- Synonyms:
- BM046
- Chromosome:
- 2q22.2-q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-07
- Date modifiied:
- 2018-02-13
- Gene:
- CAMKK1 NIH gene
- Name:
- calcium/calmodulin dependent protein kinase kinase 1
- Previous symbol:
- -
- Synonyms:
- DKFZp761M0423, CAMKKA, MGC34095
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-27
- Date modifiied:
- 2016-10-05
- Gene:
- EAF2 NIH gene
- Name:
- ELL associated factor 2
- Previous symbol:
- -
- Synonyms:
- BM040, TRAITS, U19
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-17
- Date modifiied:
- 2016-10-05
- Gene:
- GET4 NIH gene
- Name:
- golgi to ER traffic protein 4
- Previous symbol:
- C7orf20
- Synonyms:
- CGI-20, H_NH1244M04.5, CEE, TRC35
- Chromosome:
- 7p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-09
- Date modifiied:
- 2015-06-24
- Gene:
- GLYR1 NIH gene
- Name:
- glyoxylate reductase 1 homolog
- Previous symbol:
- -
- Synonyms:
- BM045, HIBDL, NP60, N-PAC
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2009-08-14
- Date modifiied:
- 2016-03-21
Related products to: SOX9 Antibody (monoclonal) (M04)
Related articles to: SOX9 Antibody (monoclonal) (M04)
- Craniosynostosis is a congenital disorder characterized by premature fusion of cranial sutures. Lambdoid synostosis is a rare and severe form of the disease, but its developmental etiology remains poorly understood. Although ectopic cartilage has been associated with lambdoid suture fusion, whether abnormal chondrocyte development is causative has not been directly tested. Here, we investigated the role of platelet-derived growth factor receptor alpha (PDGFRα) signaling in chondrocyte development and lambdoid suture morphogenesis. Mesoderm-specific expression of an autoactivated Pdgfra allele (Pdgfra+/K) caused premature fusion of the lambdoid and occipitointerparietal sutures, preceded by excessive cartilage expansion during embryogenesis. Spatial transcriptomic analysis identified a PDGFRα-dependent transcriptional program characterized by increased Col2a1, Sox9, and Sfrp2 expression, indicating maintenance of chondrocytes in a proliferative progenitor state. Consistently, PDGFRα-activated chondrocytes exhibited increased proliferation. Moreover, expression of Pdgfra+/K in the Col2a1Cre lineage selectively induced occipitointerparietal suture fusion. Together, these findings demonstrate that PDGFRα signaling promotes proliferative cartilage and impairs chondrocyte maturation, identifying dysregulated chondrogenesis as a developmental mechanism underlying lambdoid craniosynostosis. - Source: PubMed
Publication date: 2026/08/12
Bartoletti GarrettEbright RyanLiang HaoyangJaramillo JosueSammarco MimiXu XiaojiangHe Fenglei - Meniscal injury is a leading cause of early-onset osteoarthritis, yet regenerative options remain limited. This study investigates a nonwoven polyethylene terephthalate (PET) scaffold for meniscus tissue engineering and assesses its capacity to support mesenchymal stromal cell (MSC) proliferation and chondrogenic differentiation under dynamic loading. Human MSCs are seeded onto PET scaffolds (400-420 g/m, 85% porosity) and cultured for up to 21 days under basal medium (Ctr), chondrogenic differentiation conditions (ChD), or ChD combined with dynamic loading (ChD + Dyn, 12% strain, 1 Hz, 1 h/day, 5 days/week). PET scaffolds support uniform MSC adhesion and colonization. Compared with ChD alone, ChD+Dyn significantly increases cell proliferation and transiently upregulated chondrogenic markers (SOX9, ACAN, COL1A1, COL2A1) while suppressing the hypertrophic marker COL10A1. Although collagen deposition and construct biomechanics remained unchanged over 21 days, glycosaminoglycan accumulation was reduced in the ChD + Dyn group compared with ChD. RNA sequencing revealed distinct mechanosensitive transcriptional signatures induced by dynamic loading, particularly in genes associated with extracellular matrix remodeling, mechanotransduction, and developmental signaling pathways. These findings demonstrate that nonwoven PET provides a mechanically robust scaffold for meniscus tissue engineering and that dynamic loading promotes MSC proliferation while transiently regulating chondrogenic differentiation and mechanoadaptive matrix remodeling toward a meniscus-like phenotype. - Source: PubMed
Publication date: 2026/08/11
Teixeira Graciosa Quelhasde Roy LuisaFeldmeier Anna-LottaAhmad MubashirPilão SofiaAhrens MariaIgnatius AnitaLinti CarstenSeitz Andreas Martin - Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) frequently cause gastrointestinal adverse events, including diarrhea, and are associated with alterations in intestinal mucosal defense. Previous studies have shown that afatinib alters Paneth cell-associated α-defensin 5 (DEFA5)-related antimicrobial defense and epithelial transport-related molecular readouts, including cystic fibrosis transmembrane conductance regulator (CFTR) expression. - Source: PubMed
Publication date: 2026/08/11
Uemura IppeiSatoh TakashiTakahashi-Suzuki Natsuko - Temporomandibular joint osteoarthritis (TMJOA) is a degenerative joint disease involving cartilage degeneration, synovial inflammation, and subchondral bone remodeling. Current treatments are primarily palliative, lacking precise therapies. MicroRNA-based gene therapy is promising, but free miRNAs are limited by rapid degradation and poor cellular uptake. Given its marked downregulation in osteoarthritic chondrocytes and its multi-target capacity to concurrently suppress multiple matrix-degrading enzymes and inflammatory mediators, miR17 was selected as the therapeutic payload. Tetrahedral framework nucleic acids (tFNAs) offer high stability, efficient cellular uptake, and intrinsic anti-inflammatory activity, making them ideal miRNA carriers. In this study, TM17 was developed by loading miR17 onto tFNAs. Physicochemical characterization confirmed its stable structure and uniform size. In IL-1β-treated rat TMJ chondrocytes, TM17 was efficiently internalized, enhancing proliferation and migration, suppressing ROS generation and apoptosis while downregulating inflammatory factors (iNOS, MMP3, MMP13, ADAMTS5) and upregulating cartilage synthesis genes (COL2a1, ACAN, SOX9), restoring metabolic homeostasis. Mechanistically, TM17 inhibited p38 MAPK/NF-κB signaling and regulated the PTEN/AKT/HIF1α axis to reduce excessive HIF-1α activation, achieving dual anti-inflammatory and pro-synthetic effects. This first combination of tFNAs with miR17 demonstrates TM17 as a multifunctional nanodrug with efficient delivery and multitarget regulation, offering a potential strategy for TMJOA therapy. - Source: PubMed
Publication date: 2026/08/10
Liu XingyuLiao JuntongHan XiaoyuLu WeitongSun YueLin YunfengShi Sirong - Several gonadal neoplasms harbor recurrent CTNNB1 mutations, including sex cord-stromal tumors, such as Sertoli cell tumor, NOS and gonadal signet ring stromal tumor, ovarian and testicular microcystic stromal tumor (MCST), in addition to gonadal solid pseudopapillary neoplasms (SPN). Despite being classified as separate entities, they have notable morphologic and immunophenotypic similarities. Of note, gonadal SPNs have been regarded as the counterparts of pancreatic SPN, but their relationship remains poorly understood. We analyzed 28 gonadal sex cord-stromal tumors, including testicular Sertoli cell tumors NOS (n=8), MCSTs (n=2), and signet ring stromal tumor (n=6), ovarian MCSTs (n=11), signet ring stromal tumor (n=1), together with ovarian SPNs (n=4) and pancreatic SPNs (n=9). Histologic features were reviewed, and immunohistochemistry for SF-1, SOX9, WT1, β-catenin, inhibin, and calretinin was performed. CTNNB1 mutation status was assessed by NGS in selected cases. DNA methylation profiling was performed successfully in 25 tumors (61%). All gonadal tumors showed overlapping morphologic features, comprising variable combinations of tubular, solid, signet ring and microcystic patterns, although the abundance of individual patterns varied between entities. Pancreatic SPNs showed similar cytologic features to gonadal tumors and commonly exhibited solid and pseudopapillary architecture with frequent cystic structures but lacked true tubular differentiation. Immunohistochemically, SF-1 expression was present in 27/31 (87%) tested gonadal tumors whereas all pancreatic SPNs were negative (4/4). Diffuse nuclear β-catenin expression was identified in all evaluable gonadal and pancreatic tumors (35/35, 100%). SOX9 and WT1 were expressed in 19/21 (90%) and 24/25 (96%) of gonadal tumors, respectively. In contrast, pancreatic SPNs were negative for SF-1 and WT1 in all evaluable cases (4/4 each), with only a single case showing focal SOX9 positivity. Inhibin and calretinin expression was largely absent in gonadal tumors, with only rare focal or weak positivity (3 cases) and a single ovarian MCST showing diffuse calretinin expression. Methylation analysis demonstrated closely related epigenetic profiles among gonadal CTNNB1-driven tumors, regardless of their histologic classification, whereas pancreatic SPNs formed a separate cluster. These findings indicate that several CTNNB1-driven tumors of the gonads currently classified as different entities share morphologic, immunophenotypic, and epigenetic features, supporting the concept that they represent variations within the same spectrum. Despite some morphologic overlap, these gonadal tumors are different from pancreatic SPN based on DNA methylation signatures. - Source: PubMed
Publication date: 2026/08/04
Michalova KvetoslavaAcosta Andres MMartinek PetrGrendar MarianOliva EstherDevins KyleMalpica AnaisSchoolmeester J KennethSwanson Amy AXing DeyinLasota JersySangoi AnkurDundr PavelSoukup JiriUlbright Thomas MMichal Michal