Aromatase _ CYP19A1 Antibody
- Known as:
- Aromatase _ CYP19A1 Antibody
- Catalog number:
- AF1106a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- Aromatase _ CYP19A1 Antibody
Related genes to: Aromatase _ CYP19A1 Antibody
- Gene:
- CYP19A1 NIH gene
- Name:
- cytochrome P450 family 19 subfamily A member 1
- Previous symbol:
- CYP19
- Synonyms:
- ARO, P-450AROM, CPV1, ARO1, CYAR, aromatase
- Chromosome:
- 15q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: Aromatase _ CYP19A1 Antibody
Related articles to: Aromatase _ CYP19A1 Antibody
- Swainsonine (SW), the principal toxic alkaloid of locoweeds, causes significant reproductive failure in grazing livestock, but its direct cellular targets and mechanisms remain poorly defined. This study aimed to elucidate the cytotoxic effects of SW on goat ovarian granulosa cells (GCs) and the underlying molecular pathways. Based on an initial cytotoxicity profile (24 h IC₅₀ = 21.79 μM), GCs were treated with 20 μM SW for 24 h to investigate mechanistic endpoints. SW exposure significantly suppressed cell proliferation, induced G0/G1 phase arrest, and triggered apoptosis. This was associated with a state of severe oxidative stress, characterized by elevated reactive oxygen species (ROS), glutathione depletion, increased lipid peroxidation, and loss of mitochondrial membrane potential. Concurrently, SW inhibited the secretion of estradiol and progesterone, downregulating key steroidogenic genes (STAR, CYP19A1, HSD3B1). Transcriptomic analysis revealed enrichment of pathways related to oxidative stress, apoptosis, and cell cycle regulation, and suggested the involvement of MAPK signaling. Our integrated analysis reveals that SW exposure induces oxidative stress, mitochondrial dysfunction, cell cycle arrest, apoptosis, and suppressed steroidogenesis in goat GCs. Transcriptomic profiling further implicates pathways related to oxidative stress and apoptosis. These findings suggest a mechanistic framework in which oxidative stress and mitochondrial dysfunction are central to SW-induced ovarian toxicity, although the precise causal relationships require further validation. - Source: PubMed
Publication date: 2026/04/08
Zhou BoSun JinkuiHuang JiajinXiao MeimeiLi ZiyangXu HouqiangRuan Yong - Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women, characterized by hyperandrogenism and metabolic dysfunction. Dietary interventions are recommended as one of the first-line therapies. Oligofructose (OFS), a prebiotic fiber, has demonstrated clinical benefits in PCOS; however, its underlying mechanism remains unclear. - Source: PubMed
Publication date: 2026/04/13
Wang YuhuiLiu XitongLi ZhiKang AhuiBai YixuanWang YangLiu YanZhang ChujunYang JiaqiCai QingqingFeng YiYi HuanZhang MengyuZhang FeifeiLiu HaiouXu Congjian - This study investigated the expression profiles of key enzymes involved in androgen metabolism in canine sebaceous gland tumors and compared them with those in normal and hyperplastic sebaceous glands. Based on histopathological evaluation, lesions were classified as hyperplasia, adenoma, epithelioma, or carcinoma. Tissue sections from each case were examined for expression of the androgen receptor (AR); the de novo steroidogenic enzymes StAR, CYP11A1, CYP17A1, and 3β-HSD; the steroid-precursor-activating enzyme STS; the potent-androgen biosynthetic enzymes 17β-HSD3 and SRD5A1; the androgen-inactivating enzyme 17β-HSD2; and the aromatase CYP19A1, using immunohistochemistry and in situ hybridization to assess both protein and mRNA levels. Normal sebaceous glands exhibited immunoreactivity for all examined enzymes and AR except 17β-HSD3, and no significant differences were observed between normal and hyperplastic glands. In contrast, malignant sebaceous gland tumors showed marked up-regulation of AR, StAR, CYP11A1, CYP17A1, 3β-HSD, and SRD5A1, accompanied by down-regulation of 17β-HSD2 and CYP19A1 relative to both normal and hyperplastic counterparts. Collectively, these findings demonstrate that normal sebaceous glands possess an intrinsic ability for local sex-steroid biosynthesis, suggesting a role for these hormones in the physiological regulation of sebaceous gland function. Moreover, the enzyme-expression alterations observed in sebaceous gland tumors suggest a shift in the local hormonal milieu toward an increased androgenic influence. Overall, the results underscore the pivotal role of steroid metabolism in the pathogenesis of sebaceous gland tumors and suggest that androgen-biosynthetic pathways may offer promising therapeutic targets. - Source: PubMed
Publication date: 2026/04/11
İpek EmrahYıldırım FundaÖzsoy Şule YurdagülGülçubuk AhmetKaleli SüleymanEpikmen Erkmen TuğrulTunca Recai - Neohesperidin dihydrochalcone (NHDC) has been confirmed to possess excellent nutritional activities as a natural flavonoid low-calorie sweetener, but its practical application in the food industry was greatly limited due to its low water solubility. The potential NHDC activity against oxidative stress (OS) diseases was explored through network pharmacology and molecular docking technology, and a highly water-soluble NHDC-L-arginine complex (NL) was prepared by combining NHDC with L-arginine to overcome this technical bottleneck. Meanwhile, the enhancement of antioxidant capacity markers under non-stressed conditions following NL treatment was systematically investigated in (), and transcriptomic and metabolomic analyses were integrated to reveal the potential regulatory mechanism at the molecular and metabolic levels. It was found that NHDC could exert potential anti-OS effects by targeting and binding to key proteins such as CYP19A1, TYR, EPHX2, TDP1, ESR1, and SLC5A1. In addition, the MDA level in after NL intervention was significantly reduced to 0.65 ± 0.06 nmol/mg prot, while the activities of antioxidant enzymes T-SOD, GSH-Px, and CAT were significantly increased to 48.83 ± 1.75 U/mg prot, 112.95 ± 0.55 U/mg prot, and 6.30 ± 0.16 U/mg prot, respectively. Longevity regulating pathway-worm was identified as a potential key signaling pathway for NL to regulate the enhancement of antioxidant capacity markers under non-stressed conditions of at the molecular level, and the pentose phosphate pathway was the core metabolic pathway. These results could offer theoretical support for the potential development of NHDC and NL in the field of antioxidants, as well as their large-scale applications in the functional food and flavored food industries. - Source: PubMed
Publication date: 2026/04/04
Chen PingZhu SimingTian MenghanWang YutaoChen LiangWang Zhendong - Ovarian aging is characterized by progressive impairments of follicular development and reproductive performance. Increasing evidence indicates that metabolic dysregulation plays a central role in the decline of ovarian function. Chlorogenic acid (CGA), a widely distributed plant-derived polyphenol, is known for its antioxidant, anti-inflammatory, and metabolic properties. However, its potential role in ovarian aging and the underlying mechanisms remain unexplored. - Source: PubMed
Publication date: 2026/04/04
Cai XiangyuYang ZhaoyuXiao YingyuYuan QiongyuGao WanyueDong JingZeng WeidongMi YulingZhang Caiqiao