APOL3 Antibody
- Known as:
- APOL3 Antibody
- Catalog number:
- AF1085a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- APOL3 Antibody
Related genes to: APOL3 Antibody
- Gene:
- APOL3 NIH gene
- Name:
- apolipoprotein L3
- Previous symbol:
- -
- Synonyms:
- CG12-1, APOLIII
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2016-10-05
Related products to: APOL3 Antibody
Related articles to: APOL3 Antibody
- Copy number variation (CNV) is an important class of structural variations (SVs) that contribute to phenotypic diversity and environmental adaptation in animals. However, large-scale population-level analyses of CNVs in goats remain limited. This study aimed to comprehensively characterize CNVs and explore their potential roles in economically important traits in Chinese goat populations. - Source: PubMed
Publication date: 2026/05/30
Li WenzeSu YixinLiu CanYan XiaochunLv QiSu Rui - In advanced Prostate Cancer (PCa), metastatic spread and the inevitable emergence of enzalutamide resistance represent major clinical hurdles. Although apolipoprotein L3 (APOL3) is linked to oncogenesis, its precise mechanistic role in PCa progression and antiandrogen resistance, particularly its regulation of the STAT3-DAB2IP axis, remains largely unexplored. - Source: PubMed
Publication date: 2026/05/25
Wang QuanxinZuo SonglinChen LinWan FangningHong ZheXu WenhaoHou WentingYe Dingwei - Apolipoproteins L (APOLs) are membrane-associated proteins involved in both resistance to pathogens, such as APOL1-mediated killing of African trypanosomes or APOL3-mediated lysis of intracellular bacteria, and induction of diseases, like APOL1-mediated nephropathy or APOL2-mediated liver fibrosis. Accumulating evidence points to APOLs controlling membrane dynamics linked to immunity. APOL1 and APOL3 are induced by inflammatory signalling and play key roles in the initiation and termination of inflammation by promoting the traffic of Golgi-derived membranes involved in STING activation, as well as mitochondrial membrane fission and fusion involved in auto/mitophagy. APOL2, or murine mAPOL8, is required for profibrotic vesicle exocytosis, whereas mAPOL9 triggers bacterial membrane budding linked to gut immunity control. In dendritic cells, APOL3 or the APOL3-like mAPOL7C promote megapore formation in phagosomal membranes, allowing antigen cross-presentation and apoptosis, both probably linked to cardiolipin solubilization. In adipocytes, mAPOL6 controls inflammation-linked lipid droplets dynamics. Through their membrane-remodeling activities, APOLs participate in the control of infection by bacteria, viruses, and parasites. Thus, natural APOLs mutations represent inborn errors of immunity. - Source: PubMed
Publication date: 2026/03/19
Pays Etienne - Ferroptosis has emerged as a potential therapeutic target for non-small cell lung cancer (NSCLC), but its regulatory mechanisms remain elusive. Protein tyrosine kinase 6 (PTK6) is overexpressed in NSCLC and linked to poor prognosis, though its role in ferroptosis is unknown. CCK-8 assay was performed to assess cell viability. Intracellular Fe2+ level was measured using an iron assay kit. Lipid peroxidation was evaluated using the C11 BODIPY probe. Dual-luciferase reporter and ChIP assays were employed to investigate FOXO3’s interaction with the APOL3 promoter. PTK6-YTHDF2 interaction was examined using Co-IP assay, and YTHDF2-FOXO3 interaction was detected using RIP assay. PTK6 knockdown exacerbated Erastin-induced ferroptosis in NSCLC cells. Mechanistically, PTK6 enhanced YTHDF2-mediated FOXO3 mRNA degradation by phosphorylating YTHDF2. FOXO3 silencing reversed PTK6 depletion’s pro-ferroptotic effects. FOXO3 transcriptionally activated APOL3 expression. APOL3 knockdown negated PTK6 silencing-driven ferroptosis sensitization. PTK6 inhibited NSCLC cells ferroptosis by promoting m6A-YTHDF2-dependent FOXO3 mRNA degradation through phosphorylating YTHDF2, thereby suppressing FOXO3-mediated APOL3 transcriptional activation. - Source: PubMed
Publication date: 2026/04/24
Zhen ShijunZhu QingtaoWu XinzeXiong FangtaoMa WentaoWang ZishuoBo Wei - Apolipoproteins (APOs) are essentially structural and functional components of lipoproteins, which are composed of 22 members and their effects on certain types of cancer have been studied. However, their roles in endometrial cancer (EC), which is one of the most common malignant tumors in gynecology were unclear and rarely investigated. - Source: PubMed
Publication date: 2026/02/16
Zhou LinaWang RenchengDu GuiqiangWu YupengLi HuiHe YinyanYe ZhikangXiang Jiangdong