APOL1 Antibody
- Known as:
- APOL1 Antibody
- Catalog number:
- AF1083a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- APOL1 Antibody
Related genes to: APOL1 Antibody
- Gene:
- APOL1 NIH gene
- Name:
- apolipoprotein L1
- Previous symbol:
- APOL
- Synonyms:
- -
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-03
- Date modifiied:
- 2019-04-23
Related products to: APOL1 Antibody
Related articles to: APOL1 Antibody
- - Source: PubMed
Vogan Kyle - APOL1 variants confer increased risk for kidney disease in individuals of African ancestry, particularly in homozygous or compound heterozygous states. A missense variant, p.N264K, has been shown to attenuate this risk when co-inherited with the G2 allele. While these associations are established in adults, data in pediatric populations remain limited. Using the University of Tennessee Health Science Biorepository and Integrative Genomics initiative, we assessed chronic kidney disease (CKD) risk by APOL1 high-risk genotype and the potential protective effect of p.N264K in a diverse pediatric cohort. - Source: PubMed
Publication date: 2026/06/12
Zahr Rima SChinthala LokeshMohammed AkramKovesdy Csaba PDavis Robert L - high-risk variants markedly increase susceptibility to kidney disease among individuals of African ancestry; however, only a subset of carriers develops clinically significant CKD or ESKD. This discrepancy highlights a gap between genetic risk and clinical trajectory. Current prognostic tools rely primarily on eGFR and albuminuria, which incompletely reflect the underlying biological processes driving -associated kidney injury. We hypothesized that plasma biomarkers reflecting inflammatory and tubular injury pathways could identify biologically active disease states within this genetically "high-risk" population and improve prognostic stratification. - Source: PubMed
Publication date: 2026/06/05
Vasquez-Rios GeorgeChauhan KinsukNaik NidhiPattharanitima PattharawinChan LiliCampbell Kirk NNadkarni Girish NCoca Steven G - Non-HLA donor-recipient (D-R) genetic mismatches contribute to kidney allograft injury and long-term graft loss, but their clinical use is limited by the unavailability of donor DNA after transplantation. We tested whether non-invasively obtained, recipient-derived samples could be used to infer donor genotype and D-R mismatches. Genomic DNA (g-DNA) of 11 unselected kidney transplant recipients and donors underwent whole-exome sequencing (100x). Additional customized probes were added for intronic coverage (300x) of 55 targeted non-HLA genes of reported clinical relevance. Variants identified from sequencing results were compared with plasma cell-free DNA (cfDNA), urine cell-pellet DNA (U-DNA) obtained from the same recipients. Genome-wide-, exonic-, or non-synonymous exonic- mismatches in transmembrane or secreted proteins, and mismatches within target genes were benchmarked using donor g-DNA to generate mismatch scores for each D-R pair. Within each of these genomic scales of mismatch, U-DNA identified D-R mismatches significantly better than the corresponding cfDNA (P<0.001 for each comparison). U-DNA also identified gene-level mismatches in the gene, and correctly inferred established donor-origin risk alleles, including . Our findings demonstrate proof-of-concept that U-DNA in tandem with recipient genome, can non-invasively infer relevant non-HLA loci/mismatches circumventing the need for the donor's genomic DNA. - Source: PubMed
Publication date: 2026/06/02
Rajeevan NallakkandiBarsotti Gabriel CKumar AshwaniSun ZeguoReghuvaran AnandTikhonova IrinaTanvir E MSareen NiketaSwan AshleyFormica RichardMandel-Brehm CaleighRao ArundatiBesse WhitneyMiller MaureenBow LaurineDe Kumar BonyMenon Madhav C - Understanding how family history and genetic factors-particularly apolipoprotein L1 () renal risk variants (RRVs)-contribute to kidney disease risk among Black individuals continues to evolve. - Source: PubMed
Publication date: 2026/05/25
Lentine Krista LElsurer Afsar RenginClair BryanMemon Aliza AnwarEdwards John CMiyata Kana NAfsar BarisSchnitzler MarkXiao HuilingCarriker AmberAbu Al Rub FadeeHsu Chi-YuanMuiru Anthony NFreedman Barry IPhilipneri Marie DCaliskan Yasar