APOC1 Antibody
- Known as:
- APOC1 Antibody
- Catalog number:
- AF1081a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- APOC1 Antibody
Related genes to: APOC1 Antibody
- Gene:
- APOC1 NIH gene
- Name:
- apolipoprotein C1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
- Gene:
- APOC1P1 NIH gene
- Name:
- apolipoprotein C1 pseudogene 1
- Previous symbol:
- -
- Synonyms:
- lincRNA-APOC1P1-3
- Chromosome:
- 19q13.32
- Locus Type:
- pseudogene
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-07-20
Related products to: APOC1 Antibody
Related articles to: APOC1 Antibody
- Late-onset Alzheimer's disease (LOAD) is the most common multifactorial neurodegenerative disease among elderly people. LOAD is heterogeneous, and the symptoms vary among patients. Genome-wide association studies (GWAS) have identified genetic risk factors for LOAD but not for LOAD subtypes. Here, we examined the genetic architecture of LOAD based on Japanese GWAS data from 1947 patients and 2192 cognitively normal controls in a discovery cohort and 847 patients and 2298 controls in an independent validation cohort. Two distinct groups of LOAD patients were identified. One was characterized by major risk genes for developing LOAD (APOC1 and APOC1P1) and immune-related genes (RELB and CBLC). The other was characterized by genes associated with kidney disorders (AXDND1, FBP1, and MIR2278). Subsequent analysis of albumin and hemoglobin values from routine blood test results suggested that impaired kidney function could lead to LOAD pathogenesis. We developed a prediction model for LOAD subtypes using a deep neural network, which achieved an accuracy of 0.694 (2870/4137) in the discovery cohort and 0.687 (2162/3145) in the validation cohort. These findings provide new insights into the pathogenic mechanisms of LOAD. - Source: PubMed
Publication date: 2023/06/29
Shigemizu DaichiAkiyama ShintaroSuganuma MutsumiFurutani MotokiYamakawa AkikoNakano YukikoOzaki KouichiNiida Shumpei - Important sex differences exist in tau pathology along the Alzheimer disease (AD) continuum, with women showing enhanced tau deposition compared with men, especially during the mild cognitive impairment (MCI) phase. This study aims to identify specific genetic variants associated with sex differences in regional tau aggregation, as measured with PET. - Source: PubMed
Publication date: 2022/12/08
Wang XinBroce IrisDeters Kacie DFan Chun ChiehBanks Sarah Jane