ANILLIN _ Scraps (internal) Antibody
- Known as:
- ANILLIN _ Scraps (middlesequence) Antibody
- Catalog number:
- AF1062b
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- ANILLIN _ Scraps (internal) Antibody
Related genes to: ANILLIN _ Scraps (internal) Antibody
- Gene:
- ANLN NIH gene
- Name:
- anillin actin binding protein
- Previous symbol:
- -
- Synonyms:
- ANILLIN, Scraps, scra
- Chromosome:
- 7p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-03
- Date modifiied:
- 2016-10-05
Related products to: ANILLIN _ Scraps (internal) Antibody
Related articles to: ANILLIN _ Scraps (internal) Antibody
- Although there are several proteomic studies testing brain responses to glucocorticoids, there were no attempts to integrate these data and compare them with responses at the level of mRNAs. Furthermore, the utility of available data is compromised by changes in nomenclature and usage of different types of identifiers. Therefore, the aim of this study was to identify the most consistent changes in protein expression in standardized mouse, rat, and human datasets and compare them with transcriptomic responses to glucocorticoids. The analysis showed that the two most frequently and consistently detected proteins were ATP synthase F1 subunit beta (Atp5f1b) and aldolase, fructose-bisphosphate C (Aldoc), while the most consistent proteomic and transcriptomic findings included Aldoc, Plin4, Aqp4, Endod1, Glul, Anln, Aldh1l1, Parp1, Trf, Fermt2, Tmem63a, and Trim2. The study also revealed limitations of available proteomic data indicating significant gaps in knowledge. Finally, the study provides an integrated dataset with updated protein nomenclature and a complete set of major identifiers to facilitate usage of proteomic data. - Source: PubMed
Juszczak Grzegorz R - Non-small cell lung cancer (NSCLC) remains a major cause of cancer mortality. The Tumor Immune Dysfunction and Exclusion (TIDE) score is widely used to estimate immune-checkpoint blockade response, but its broader prognostic relevance in unselected NSCLC populations is unclear. This study aimed to determine whether TIDE-informed strata carry prognostic information beyond immunotherapy settings, and to develop and externally validate an immune gene expression-based prognostic signature derived from differentially expressed genes (DEGs) between these strata. - Source: PubMed
Publication date: 2026/02/26
Zhou JiaxuanLi NaLi ZimengChen JinmiaoDu YifeiLi XinchunWan Qi - Exosomes can promote tumor development and regulate tumor immune responses, making them of significant value in Lung Adenocarcinoma (LUAD) management. In-depth exploration of exosome-related genes in LUAD is of great significance for expanding LUAD clinical treatment options. - Source: PubMed
Publication date: 2026/03/23
Miao YajunLi TaoLi RongLiu Yufei - Poor outcomes in proteinuric kidney diseases are challenging to successfully manage therapeutically due to the heterogeneity of underlying disease pathogenesis and associated risk for progression. The role of cytoskeleton-associated proteins, including the scaffolding protein Anillin (ANLN), are of specific interest in kidney disease given the importance of actin dynamics in the kidney's specialized epithelial cell types. In this study, we identify the prevalence of genetic variants in , the gene encoding ANLN, in a cohort of deeply phenotyped individuals with non-diabetic proteinuric kidney disease. Thirty-one individuals (of 864 genotyped) harbor heterozygously expressed variants in ; 7 unrelated individuals shared the same variant (I1109V) in the C-terminal pleckstrin homology (PH) domain, a region necessary for interaction with the plasma membrane. Kidney organoids generated from I1109V induced pluripotent stem cells from 1 of these individuals showed increased epithelial cell mitogen-activated protein kinase 8 network activity and apoptosis, which was enhanced by tumor necrosis factor alpha (TNF-α) and phenocopied by actin polymerization inhibition. TNF-α-treated I1109V organoids also exhibited tubular lumen expansion. Knockdown and re-expression of the analogous ANLN variant in embryonic epithelia resulted in defects in cell-cell junction dynamics including wavy cell membranes exhibiting increased transverse movements as well as abnormal junctional F-actin remodeling in response to mechanical stress and leaky barrier function. Taken together, these results indicate that enhanced tubular epithelial cell death, perturbed cell-cell contacts and barrier function defects are associated with a novel ANLN variant discovered in individuals with non-diabetic proteinuric kidney disease. - Source: PubMed
Publication date: 2026/03/26
Craig ZieJacobs Holly MFermin DamianFischer MatthewLiu XiaoyunBerthier Celine CSmith Jalen AEl Saghir JamalEddy SeanAlaba MathewWheeler SamanthaVega-Warner VirginiaGodfrey BradleyAlakwaa FadhlLarkina MariaEichinger FelixMenon RajasreeMinakawa AkihiroKretzler MatthiasWeng ShinuoMiller Ann LHarder Jennifer L - Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin-aniline (Btn-An) remains suboptimal. To overcome this limitation, we performed yeast surface display-based directed evolution to enhance APEX2 activity toward Btn-An. The resulting variant, APEX2, exhibits an approximately two-fold improvement in labeling efficiency, likely through enhanced enzyme-substrate interactions. This increased activity enables rapid and efficient proximity labeling while maintaining spatial specificity. After validating its performance at the ER membrane, we applied APEX2 to profile the transcriptome proximal to the midbody and identified ANLN as a previously unreported midbody-localized mRNA during telophase. Drug perturbation and reporter assays further revealed that ANLN mRNA targeting to the midbody occurs co-translationally and depends on its nascent N-terminal peptide. Together, this work establishes APEX2 as an improved and versatile tool for spatially resolved transcriptomics in complex subcellular contexts. - Source: PubMed
Publication date: 2026/03/28
Wang GangLi YiMeng PeiyuanZou Peng