AKR1C3 Antibody
- Known as:
- AKR1C3 Antibody
- Catalog number:
- AF1047a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- AKR1C3 Antibody
Related genes to: AKR1C3 Antibody
- Gene:
- AKR1C3 NIH gene
- Name:
- aldo-keto reductase family 1 member C3
- Previous symbol:
- HSD17B5
- Synonyms:
- KIAA0119, DDX, HAKRB, PGFS
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-29
- Date modifiied:
- 2016-10-05
Related products to: AKR1C3 Antibody
Related articles to: AKR1C3 Antibody
- The peri-implantation period in pigs is critical for establishing pregnancy and is tightly regulated by metabolic and hormonal cues. We hypothesised that adiponectin (ADPN), an adipokine involved in energy homeostasis and insulin sensitivity, modulates the secretion of endometrial prostaglandin (PG) E and F and the expression of apoptotic factors in a pregnancy stage-dependent manner. Additionally, we explored potential interactions between ADPN and insulin (INS) in the regulation of these processes. Endometrial explants from gilts on days 10-11, 12-13, 15-16, and 27-28 of pregnancy, and days 10-12 of the oestrous cycle were cultured with ADPN (1 or 10 µg/mL) and/or INS (10 ng/mL). PG concentrations in culture media and apoptotic markers in tissue homogenates were measured using ELISA. Gene and protein expression of PG synthesis enzymes (COX-2, mPGES-1, AKR1C3, and CBR1) were analysed via qPCR and Western blot, respectively. ADPN modulated PG secretion in a pregnancy stage-dependent manner, stimulating PGE and PGF production during implantation and placentation (days 15-28), likely through the upregulation of COX-2 and/or mPGES-1. In earlier stages, ADPN reduced COX-2 expression but increased the levels of other enzymes without significantly affecting PG output. INS modified the effects of ADPN in a stage-specific manner, suggesting a complex hormonal cross-talk between those hormones. Overall, ADPN exhibited anti-apoptotic properties, although it increased Fas levels at higher concentrations. In conclusion, ADPN regulates PG synthesis and apoptotic signalling in the porcine endometrium in a stage-specific manner, supporting its role in endometrial remodelling, embryo implantation, and early pregnancy maintenance. - Source: PubMed
Publication date: 2026/04/10
Kiezun MartaDobrzyn KamilKaminski TadeuszSmolinska Nina - L. (Rosaceae), belongs to a genus well recognized in traditional medicine for treating gynecological disorders and hormonal imbalance; however, the specific bioactivity of itself remains poorly characterized. This study aimed to elucidate the phenolic composition and the biological potential of the methanolic (MeOH) extract of . LC-MS/MS analysis identified 39 phenolic compounds, with rutin, catechin, kaempferol-3--glucoside, and caffeic acid being the dominant constituents. The extract exhibited high total phenolic and flavonoid contents, consistent with strong antioxidant capacities. It demonstrated notable α-glucosidase and acetylcholinesterase inhibitory activities, indicating its potential relevance for metabolic and neurodegenerative disorders. The extract effectively reduced AAPH-induced ROS levels in MRC-5 fibroblasts, indicating cytoprotective and antioxidative effects. The cytotoxicity toward cervical cancer cells HeLa and ovarian cancer cells A2780 was moderate and concentration dependent. A yeast-based fluorescent screen revealed a strong and selective binding affinity toward estrogen receptor α (ERα) and selective inhibition of human recombinant AKR1C3 (59.5%), without affecting AKR1C4. Additionally, high COX-1/COX-2 inhibition (>70%) supported its anti-inflammatory potential. Collectively, these findings provide the first integrated evidence of 's phenolic richness and multifunctional bioactivity, scientifically supporting its potential in managing hormone-dependent and oxidative stress-related disorders. - Source: PubMed
Publication date: 2026/03/26
Krstić SanjaBekić SofijaŽivanović NemanjaPirković AndreaVuković JovanaBauer RudolfRašeta Milena - The musk gland of male forest musk deer () secretes musk enriched with sex steroid hormones. The testes mainly produce these hormones; however, whether glandular cells can autonomously synthesize them remains unexplored. This study aimed to utilize an in vitro-cultured musk gland cell model to investigate whether musk gland cells possess the capability for autonomous synthesis of sex steroid hormones. We used single-cell RNA sequencing (scRNA-seq), reverse transcription quantitative real-time polymerase chain reaction, and liquid chromatography-mass spectrometry (LC-MS) to verify the steroidogenic potential of musk gland cells. scRNA-seq revealed that during the secretion period, 18 cholesterol and 6 sex steroid hormone biosynthesis genes were significantly expressed in the cells. In vitro experiments demonstrated that these genes were expressed without exogenous cholesterol supplementation. LC-MS analysis confirmed stable synthesis of nine sex steroid hormones. Increasing cholesterol concentration to 20 mg/L significantly upregulated and , with expression showing an upward trend. Elevated cholesterol increased several sex steroid hormone levels: pregnenolone, progesterone, 17α-hydroxypregnenolone, androstenedione, androsterone, and etiocholanolone by 4.12-, 1.46-, 33.42-, 2.06-, 3.11-, and 5.65-fold, respectively. These results collectively indicate that the musk glandular cells can synthesize sex steroid hormones de novo and suggest that cholesterol may regulate their biosynthesis in these cells. - Source: PubMed
Publication date: 2026/04/06
An XianHan XiangyuHuang JinmingZhang ZexiuLou ZhiyiHu JingyaoTan RongzengYang PengchengDou XinyueBati HabibZhao YuetongZhang YeleDou XinZhang HenghaoLiu ShuqiangYao Congxue - Radioresistance is one of the primary causes of prostate cancer treatment failure and post-radiotherapy progression. However, there is currently a lack of effective targets to increase radiotherapy sensitivity and inhibit malignant progression. We identified AKR1C3 as a potential key target associated with radioresistance and malignant progression through integrated bioinformatic analysis of RNA sequencing (RNA-seq) data from prostate cancer clinical samples in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The promotion of radioresistance by AKR1C3 in both AR-positive and AR-negative prostate cancer cells was further validated through in vivo and in vitro experiments. Mechanistic studies revealed that AKR1C3 can bind to PKM2 and accelerate its degradation, thereby inhibiting glycolytic flux and enhancing oxidative phosphorylation (OXPHOS). Increased OXPHOS boosts ROS production, which further promotes NRF2 nuclear translocation, activating the transcription of DNA repair protein UBE2T. This enhanced DNA damage repair ability enables prostate cancer cells with high AKR1C3 expression to exhibit greater resistance to radiotherapy. In summary, this study reveals the molecular mechanism by which AKR1C3 is involved in metabolic reprogramming to promote radioresistance in prostate cancer through PKM2/UBE2T. These findings indicate that targeting AKR1C3 has potential for overcoming radioresistance, providing novel insight into the clinical treatment of prostate cancer. - Source: PubMed
Publication date: 2026/03/30
Zhang JinyuLi JiongzhengYan YufeiWang BinghuanWang RuojiaCui XiaoliZhan YangLiang ZuowenLi Jing - Neuroblastoma (NB) progression is influenced by metabolic and redox adaptations. The polyol pathway, driven by aldose reductase (AKR1B1) and sorbitol dehydrogenase (SORD), is activated in hyperglycemic conditions, while detoxification of lipid peroxidation products such as 4-hydroxynonenal (4-HNE) involves carbonyl reductase 1 (CBR1) and AKR1B1. A systematic characterization of these enzymes under distinct metabolic and oxidative challenges in NB is currently lacking. - Source: PubMed
Publication date: 2026/02/27
Avanatti MartinaSardelli GemmaMosca RossellaBalestri FrancescoSignore GiovanniFelice FrancescaDel Corso AntonellaMoschini Roberta