AGTR1 _ AT1 Antibody
- Known as:
- AGTR1 _ AT1 Antibody
- Catalog number:
- AF1036a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- AGTR1 _ AT1 Antibody
Related genes to: AGTR1 _ AT1 Antibody
- Gene:
- AGTR1 NIH gene
- Name:
- angiotensin II receptor type 1
- Previous symbol:
- AGTR1B
- Synonyms:
- AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2017-07-07
Related products to: AGTR1 _ AT1 Antibody
Related articles to: AGTR1 _ AT1 Antibody
- Antihypertensive therapy is pivotal in preventing cardiovascular events, yet treatment efficacy varies significantly among individuals due to genetic polymorphisms.This study aimed to investigate the association between specific antihypertensive drug-related gene polymorphisms, the use of corresponding sensitive drugs, and the risks of stroke and coronary heart disease (CHD) in a community-based hypertensive population. A cross-sectional study was conducted among 29,662 hypertensive patients from primary care centers in Changsha County, China. Seven gene loci (ACE(I/D), CYP2C9*3,AGTR1(1166 A > C), CYP2D6*10,ADRB1(1165G > C), CYP3A5*3, and NPPA(2238T > C))were genotyped.Patients were stratified into sensitive or non-sensitive genotype groups. Logistic regression and interaction analysis were employed to assess gene-drug interactions on cardiovascular outcomes. The prevalence of stroke and CHD was 2.8% and 19.5%, respectively. Carriers of sensitive genotypes for AGTR1, CYP2D6*10, and ADRB1 taking sensitive drugs exhibited a significantly lower risk of stroke (ORs: 0.39, 0.67, 0.68; all P < 0.01). Similarly, sensitive genotype carriers for CYP2D6*10, CYP3A5*3, and NPPA taking sensitive drugs had a reduced risk of CHD (ORs: 0.92, 0.88, 0.53; all P < 0.05). A significant additive interaction was identified between AGTR1(1166 A > C) and sensitive drug use on CHD risk (AP = 0.08). Pharmacogenomics-guided antihypertensive therapy is associated with a reduced risk of stroke and CHD in hypertensive patients. The interaction between AGTR1(1166 A > C) genotype and drug use underscores the potential of personalized medicine in optimizing cardiovascular disease prevention strategies in primary care. - Source: PubMed
Publication date: 2026/04/12
Li ZetongLiu HuixiaChen MengshiDeng JingMa ZiyuHuang GeLi ChengSu MengZhong Hua - Recently, multicomponent quality-of-life indicators have become increasingly important in monitoring the health status of patients with hypertension and evaluating the effectiveness of treatment. Improving patient quality of life is considered one of the key objectives of the medical intervention. To assess the quality of life of patients with, we used the standardized SF-36 (Short Form-36 Health Survey) questionnaire, which allows to explicitly examine the respondent physical and psycho-emotional status. We analyzed the association between polymorphisms of endothelial nitric oxide (NO) synthase (eNOS) (NOS3, T786C) and angiotensin II receptor type 1 (AGTR1, A1166C) genes and quality of life. Patients with polymorphisms associated with lower intravascular pressure had lower baseline QoL scores, particularly on the "physical functioning" and "general health" scales (p<0.05). Patients with heterozygous or homozygous "unfavorable" genotypes (AGTR1_CC, NOS3_CC) have significantly lower total indicators of both physical and psycho-emotional health compared to patients with "better" genotypes (AA, TT) and the control group. Patients with polymorphisms that cause reduced bioavailability of NO or excessive activation of AGRT1 show a significant deterioration in quality of life on all key SF-36 scales. This indicates the significant role of genetic factors in shaping the subjective perception of health in patients with arterial hypertension. - Source: PubMed
Publication date: 2026/03/24
Pidruchna SvitlanaYarema NadiyaKuzmak IrynaProkopovych OlenaShmanko VolodymyrShmanko OlehLykhatskyi PetroOstrivka OksanaMudra AllaPalytsya LylyaLetniak NataliyaYaroshenko TetyanaPohorielova OksanaChernyshenko Olena - Antibody-mediated rejection (AMR) is a leading cause of kidney allograft loss. Anti-angiotensin II type-1 receptor (AT1R) autoantibodies (AABs) have been implicated in AMR and microvascular inflammation (MVI), particularly in C4d-negative and non-HLA antibody dependent cases. Conventional assays measure only total IgG and do not assess pathogenic subclass heterogeneity. Whether IgG1-IgG4 subclass profiling improves AMR prediction has not yet been investigated. - Source: PubMed
Publication date: 2026/03/02
Mizera JakubMarek-Bukowiec KarolinaMoll GuidoCatar RusanHeidecke HaraldSchulze-Forster KaiJerzak PatrykRakowski MateuszWładyczak KarolinaHałoń AgnieszkaJanczak DariuszDonizy PiotrBanasik Mirosław - Hypertension, or high blood pressure, is a long-lasting condition caused by sustained high blood pressure in the arteries. The increase and decrease of blood pressure is greatly affected by both dietary and physiological factors. Hence, hypertension may pose serious risks of developing multiple disorders, such as heart and vascular disorders and diabetes, since it is usually not detected for a long time, and thus, it can even speed up the development of some diseases. - Source: PubMed
Publication date: 2026/03/12
Thomas Sheena MariamAnilkumar Anu ShibiVeerabathiran Ramakrishnan - Obesity is characterized by chronic low-grade inflammation, which plays a central role in the development of its metabolic complications. The genetic factors influencing this inflammatory phenotype remain incompletely understood. This study aimed to analyze the associations of functional polymorphisms in genes involved in extracellular matrix remodeling (, , , ), metabolism (), and vascular regulation (, ) with plasma cytokine profiles and to identify inflammatory subphenotypes in patients with obesity. The study included 127 individuals, comprising 73 patients with excess body weight (body mass index, BMI ≥ 25 kg/m) and 54 individuals with normal weight (BMI 18.5-24.9 kg/m). Genotyping of selected polymorphisms was performed using real-time PCR. Plasma concentrations of 47 cytokines and chemokines were measured by multiplex immunoassay. Nominally significant associations between genetic variants and cytokine levels were identified. Polymorphisms rs1107946 (CA genotype) and rs17576 (AG genotype) were associated with a favorable inflammatory profile (decreased IL-6 and increased IL-10, respectively). In contrast, the rs5186 (AC genotipe) variant was associated with elevated TNF-α, IP-10/CXCL10, while the rs1801131 (AC genotipe) variant was linked to increased MIP-1β/CCL4, both reflecting a pro-inflammatory shift. Complex, pleiotropic associations were observed for rs243865 (elevated IL-7 and Fractalkine/CX3CL1) and rs1799983 (elevated MCP-1/CCL2 and Eotaxin/CCL11). Cluster analysis revealed distinct patient subpopulations with differing inflammatory signatures. In one well-defined subgroup, an exploratory model (test R = 0.537) identified IL-8, IL-15, and albumin as candidate biomarkers predictive of BMI. The study identifies candidate genetic polymorphisms and inflammatory biomarkers associated with distinct patterns of systemic inflammation in obesity. These hypothesis-generating findings underscore the phenotypic heterogeneity of obesity and provide a basis for further research into the stratification of patients by the risk of developing metabolic complications. - Source: PubMed
Publication date: 2026/02/17
Rashidova Leyla OShashnin Danila DZubeev Pavel SAbalikhina Elena PPodprugina Natalia GKozlov Valeriy AStasenko Sergey VMishchenko Tatiana AVedunova Maria V