AGR2 Antibody
- Known as:
- AGR2 Antibody
- Catalog number:
- AF1035a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- AGR2 Antibody
Related genes to: AGR2 Antibody
- Gene:
- AGR2 NIH gene
- Name:
- anterior gradient 2, protein disulphide isomerase family member
- Previous symbol:
- -
- Synonyms:
- XAG-2, HAG-2, AG2, PDIA17
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-06
- Date modifiied:
- 2016-10-05
Related products to: AGR2 Antibody
Related articles to: AGR2 Antibody
- Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide, primarily due to distant metastasis. Tumor-associated neutrophils (TANs), a major component of the tumor microenvironment (TME), play multifaceted roles in tumor progression. However, the molecular mechanisms by which TANs regulate epithelial-mesenchymal transition (EMT) in CRC remain unclear. This study aims to investigate how TANs promote CRC progression through EMT. CRC and paired adjacent normal tissues were collected for Western Blot, IHC, and flow cytometry to evaluate ALYREF and CD66b expression. NB-4 cells were induced with all-trans retinoic acid to generate TANs, and conditioned medium (TAN-CM) was collected for co-culture with CRC cells. Malignant phenotypes of CRC cells were assessed by CCK-8, EdU, and transwell assays. The m5C modification level and stability of Snail mRNA were determined by MeRIP and actinomycin D assays. Protein and RNA interactions were examined using Co-IP and RIP. A dual-luciferase reporter assay was used to evaluate the interaction between ALYREF and the m5C site in Snail mRNA. CHX assay was performed to assess ALYREF protein stability. A subcutaneous xenograft model with neutrophil depletion was established to validate the role of the AGR2-ALYREF-Snail axis in vivo, followed by HE staining and IHC analysis of tumor tissues. The infiltration of TANs was positively correlated with ALYREF expression in CRC. TAN-secreted AGR2 stabilized ALYREF, enhancing its recognition of m5C sites in Snail mRNA, thereby increasing Snail stability and promoting EMT. Blockade of AGR2 mitigated TAN-induced CRC cell proliferation, migration, and EMT, while ALYREF overexpression partially rescued these effects. In vivo, AGR2 overexpression promoted tumor growth and EMT through neutrophil-dependent activation of the ALYREF-Snail axis. TAN-secreted AGR2 enhances ALYREF stability, thereby promoting m5C-dependent Snail mRNA stabilization and sustaining EMT and CRC progression. - Source: PubMed
Zeng WeiXiao JingleiXie JianhongLi Yu - nasal carriage contributes to asymptomatic transmission in both community and healthcare settings. This study aimed to characterize strains isolated from students of the Pomeranian Medical University in Szczecin, Poland, using phenotypic and genotypic methods. A total of 175 strains were isolated from the nasal vestibules of 800 students between 2014 and 2015. Species identification and antimicrobial susceptibility testing were performed using standard microbiological methods, while virulence-associated genes and groups were analyzed using Single-PCR and Multiplex-PCR assays. Genotypic diversity was assessed by pulsed-field gel electrophoresis (PFGE). The prevalence of nasal carriage among students was 21.9% and did not differ according to faculty or year of study. Most isolates (84.0%) were susceptible to all tested antibiotics, and no methicillin-resistant (MRSA) strains were detected. All strains carried the gene, whereas and were identified in 93.7% and 93.1% of isolates, respectively. In addition, the gene was detected in 22.3% of strains, while the / genes were identified in only one isolate (0.6%). The most prevalent enterotoxin genes were (17.1%) and (13.7%), whereas genes of the cluster, including , , and , were detected in 53.7% of isolates. Significant associations were observed between specific gene combinations and superantigen gene profiles, including increased frequencies of , , and genes ( < 0.001). The predominant type was (49.7%), followed by (28.6%) and (20.0%). Strains carrying more frequently harbored the cluster as well as the , , and genes, whereas -positive isolates were significantly associated with the and clusters and with the presence of , , and genes ( < 0.05). PFGE analysis demonstrated substantial genetic heterogeneity among the isolates, with no evidence of a predominant clonal lineage. These findings indicate a heterogeneous, non-epidemic population structure of strains circulating among university students and highlight the considerable diversity and interrelationships of virulence-associated genetic profiles within this population. - Source: PubMed
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