ACSL5 Antibody
- Known as:
- ACSL5 Antibody
- Catalog number:
- AF1020a
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- ACSL5 Antibody
Related genes to: ACSL5 Antibody
- Gene:
- ACSL5 NIH gene
- Name:
- acyl-CoA synthetase long chain family member 5
- Previous symbol:
- FACL5
- Synonyms:
- ACS5, ACS2
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-14
- Date modifiied:
- 2017-06-13
Related products to: ACSL5 Antibody
Related articles to: ACSL5 Antibody
- Egg weight (EW) is a key trait in both breeding and production for poultry. Although Zi geese demonstrate good egg-laying performance, they have relatively low EW. Identifying candidate genes and pathways associated with EW in geese is essential for enhancing genetic progress. In this study, 260 female Zi geese at 30 weeks of age were monitored individually for egg number (EN) and EW. Thirty geese, showing no significant differences in body weight and EN but significant variation in EW (P < 0.05), were selected and divided into a high egg weight (HEW) group (n = 15) and a low egg weight (LEW) group (n = 15). Egg quality traits were evaluated for both groups. From each group, six geese were randomly selected for serum biochemical profiling and untargeted metabolomics; four of these were further analyzed for transcriptomic data from the liver, ovary, and oviduct magnum. The results showed significant differences in albumen weight, yolk weight, and shell weight between HEW and LEW (P < 0.01). Serum biochemical analysis revealed higher levels of total cholesterol, triglycerides, estradiol, very low-density lipoprotein, and vitellogenin in the HEW group (P < 0.05). Transcriptomic analysis identified 278 differentially expressed genes (DEGs) in the liver, primarily enriched in antigen processing and presentation pathways, with ACACB, FDFT1, and HSPA2 highlighted as candidate genes. In the ovary, 18 DEGs were identified, with RBP1 as the key gene. In the oviduct magnum, 1,605 DEGs were enriched in protein processing in the endoplasmic reticulum, with HSPA8, HSP90AA1, and ST3GAL4 identified as candidate genes. Serum metabolomics revealed metabolites associated with EW, including cholesterol sulfate, l-tryptophan, indoxyl sulfate, and LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0). Integrated multi-omics analysis identified ACSL5-LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0) and ACSL5-L-tryptophan as key gene-metabolite pairs potentially regulating EW. These findings provide a theoretical foundation for understanding the genetic mechanisms underlying EW regulation in geese. - Source: PubMed
Publication date: 2026/03/21
Cong KexinLiu YunuoWang HechuanJiang KeYin JiaxinMiao XinyiYang WeiranXiao XiangChen ZhifengLiu Shengjun - Peroxisomes play essential roles in cellular lipid metabolism and redox regulation, yet their contribution to bladder cancer (BLCA) progression remains poorly defined. - Source: PubMed
Publication date: 2026/03/04
Wu QinghuiZhou YuOu ZhewenFu HoushengZeng FanchangLi DaoyuanZheng ZhaocongWang Fei - Metabolic reprogramming is a key cancer hallmark, with dysregulated fatty acid metabolism critical for tumorigenesis and progression. The acyl-CoA synthetase long-chain (ACSL) family (ACSL1-ACSL6) catalyzes ATP-dependent activation of long-chain fatty acids into acyl-CoA, a bioactive intermediate in lipid synthesis, β-oxidation, membrane biogenesis, and signal transduction. Dysregulated ACSL expression is widespread in malignancies, but their non-metabolic functions (ferroptosis regulation, tumor immune microenvironment remodeling) and translational potential of targeted therapies remain to be systematically summarized. - Source: PubMed
Li HaocaiWang WeijianZhan JunchengXiao YuxiangChen XiaopingSu ChenZhu Peng - In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was performed on the hypothalamus, pituitary, and liver tissues of 12-month-old greater amberjack () with different growth rates. In total, 504 (118 up- and 386 down-regulated), 556 (283 up- and 273 down-regulated), and 699 (224 up- and 475 down-regulated) differentially expressed genes (DEGs) were identified in the hypothalamus, pituitary, and liver tissues, respectively. GO and KEGG pathway analyses revealed significant differences in the expression of several genes involved in growth, metabolism, and immune-related pathways. The mRNA expression levels of genes related to growth (, , ), cell proliferation (, , , , and ), and lipid metabolism (, , , , and ) were up-regulated in the fast-growing (FG) group, while the and were down-regulated. Conversely, genes associated with glycolysis (, , ), citrate cycle (, ), and immune-related pathways (, , , , , , and ) were up-regulated in the slow-growing (SG) group. These findings indicate that the FG exhibited greater lipid metabolism capacity and cell proliferation ability, while the SG expended additional energy to cope with environmental stress, with hindered growth during immune response. This study enhances our understanding of the genetic mechanisms underlying differences in growth rates and provides essential gene resources for future growth-related molecular breeding programs in greater amberjack. - Source: PubMed
Publication date: 2026/02/06
Ru XiaoyingLi XiaojingHuang YangChen PeipeiDeng QiuxiaLi HangZhou QibingLin HaoyiHao RuijuanLiao YongguanWu JinhuiZhao YanfeiZhu Chunhua - Heterosis or hybrid vigor is a well-recognized biological phenomenon, where crossbred progeny exhibit superior growth performance, stress tolerance, and productivity compared to their purebred parents. However, the molecular mechanisms underlying heterosis for meat quality traits in pigs remain poorly understood. In this study, we compared the longissimus dorsi muscle transcriptomes of Songliao Black Pig (SBP), Large White × Landrace pig (LWLDP), and their crossbred progeny (BXW) to uncover genetic mechanisms contributing to hybrid vigor in meat quality. Results identified 4290 differentially expressed genes (DEGs) in SBP vs. BXW and 3820 in LWLDP vs. BXW. Among these, 1358 genes displayed overdominant expression in BXW, indicating potential heterotic activation. Functional enrichment analysis identified key pathways involved in lipid metabolism, energy homeostasis, and muscle growth, including mTOR, AMPK, insulin, PI3K-Akt, MAPK, and calcium signaling. Over dominantly expressed genes such as , , , , , , , , , , , , and members of the were closely associated with intramuscular fat deposition, oxidative metabolism, and tenderness. Phenotypically, BXW exhibited improved meat color, moderate fat deposition, and lower shear force compared with parental breeds, clearly aligning with transcriptomic findings. These transcriptomic findings offer valuable insights into precision breeding strategies targeting superior meat quality through genomic selection and crossbreeding programs. - Source: PubMed
Publication date: 2026/01/29
Suthar Teerath KumarZhao ZiyiLi MinZhang JingboZhang YunpengSun Wu-ShengZhao YuanZhang Shu-Min