ACOX2 Antibody
- Known as:
- ACOX2 Antibody
- Catalog number:
- AF1019b
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- ACOX2 Antibody
Related genes to: ACOX2 Antibody
- Gene:
- ACOX2 NIH gene
- Name:
- acyl-CoA oxidase 2
- Previous symbol:
- -
- Synonyms:
- BRCACOX, BRCOX, THCCox
- Chromosome:
- 3p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2016-06-01
Related products to: ACOX2 Antibody
Related articles to: ACOX2 Antibody
- Oxidative stress (OS) is increasingly implicated in benign prostatic hyperplasia (BPH), yet the underlying cellular programs remain unclear. We integrated multi-omics and machine learning to identify OS-associated biomarkers and to characterize OS-linked stromal states, with targeted experimental validation. - Source: PubMed
Publication date: 2026/04/01
Chen JieBai JingxingChen BoHuang YinLi JinzeChen ZeyuRan BiaoWei QiangAi JianzhongLiu LiangrenCao Dehong - Peroxisomes play essential roles in cellular lipid metabolism and redox regulation, yet their contribution to bladder cancer (BLCA) progression remains poorly defined. - Source: PubMed
Publication date: 2026/03/04
Wu QinghuiZhou YuOu ZhewenFu HoushengZeng FanchangLi DaoyuanZheng ZhaocongWang Fei - Radiotherapy is constricted by collateral normal tissue injury during treatment, particularly the gastrointestinal tracts, which is usually referred as radiation-induced gastrointestinal syndrome (RIGS). Currently, there is no FDA-approved agent for the prevention or treatment of RIGS. By using a mice model of RIGS, we demonstrated that 1,2-propanediol (1,2-PD) prevents radiation-induced fatal intestinal injury and significantly increases mice survival following lethal doses of radiation. 1,2-PD pretreatment also enhanced the survival of Lgr5ISCs and improved crypts regeneration after radiation. Moreover, we confirmed 1,2-PD induces dormant cell cycle arrest in enterocytes and ameliorates DNA damage both in vitro and in vivo. Although we did have observed 1,2-PD pretreatment inhibiting P53-PUMA signal pathway, but fail to prove its relation with radiation resistance. In RNA sequencing, we have observed 1,2-PD pretreatment significantly upregulates the Hif-2α, Hif-3α and PPARα target gene ACOX2, whilst downregulating the cell cycle drivers E2f3 and Cyclin D2. These results demonstrate that ISCs play a key role in radiation-induced intestinal regeneration and that 1,2-PD acts as a potent intestinal radioprotector. - Source: PubMed
Publication date: 2026/03/11
Zhao JiweiZhao ChunanShen XingJiang YingWang XunJi AoqiangZhang XuewenXing ShuangSun GangXiao HeYu Zuyin - This work conducted a transcriptome analysis of canine intestinal epithelial cells (cIECs) treated with nicotinamide mononucleotide (NMN), a physiologically active nucleotide with a pyridine base known for its anti-aging and anti-inflammatory effects. In our experiment, cIECs were cultured and segregated into a control group (Ctrl) and an NMN-treated group. The finding demonstrated that NMN significantly affects cell proliferation in cIECs in comparison to the Ctrl. The transcriptome analysis indicated a high enrichment of genes associated with the cell cycle, proliferation, cellular senescence, and inflammatory pathways in NMN-treated cIECs, showing that NMN has the capacity to modify these biological processes. Compared to the Ctrl group, NMN treatment significantly increased ATP, SOD, CAT and GSH levels and decreased the activities of ROS and MDA. NMN treatment also significantly increased the activity of the relative complex I, III and V enzymes compared to the Ctrl group. Furthermore, the expression of , , , and were decreased significantly, while , , and were increased significantly in NMN-5μM treatment compared to Ctrl. NMN-treated significantly decreased the expression of , and , while increasing the expression of Kdm5a, Kdm5b and Kdm5c compared to the Ctrl group. Additionally, ChIP-qPCR use discovered that NMN-treatment significantly downregulated the enrichment of EDN-1 at target loci of , , , and compared to the Ctrl group. Expression of the gene suggests that its exert in biological activities by inhibiting inflammatory responses and anti-aging pathways. Then, we detected the transcriptional activation linked histone markers and found that and were significantly downregulated, while was significantly upregulated in the NMN-treatment compared to the Ctrl group. We conclude that NMN regulates EDN-1 expression in cIECs through mechanisms involving NR4A1 and histone modifications, highlighting its potential role in canine intestinal health. - Source: PubMed
Publication date: 2026/02/13
Guo XudongZhu ChuyangAdam Saber YZhu CuipengLiu Hao-YuCai Demin - Polycystic ovary syndrome (PCOS) is increasingly recognized as a metabolic disorder, with dysregulated lipid metabolism emerging as a key factor in its pathogenesis. However, the precise mechanisms underlying this relationship remain unclear. We employed a summary data-based Mendelian randomization (SMR) approach to investigate the potential causal relationships between lipid metabolism-related genes and PCOS. First, we integrated PCOS genome-wide association study (GWAS) data from the Finngen_R11_E4_PCOS cohort with three layers of blood-based molecular quantitative trait loci (QTLs): methylation QTLs (mQTLs), expression QTLs (eQTLs), and protein QTLs (pQTLs). To ensure the robustness of the SMR signals, we performed the heterogeneity in dependent instruments (HEIDI) test to detect potential horizontal pleiotropy and conducted colocalization analysis to identify shared potential causal genetic variants. Findings were validated in two independent cohorts: Phenocode_265.4 and Felix. We then integrated mQTL and eQTL data to further dissect methylation-mediated gene expression regulation. Finally, we examined the expression profiles of key candidate genes using publicly available transcriptomic datasets from the Gene Expression Omnibus (GEO) database. - Source: PubMed
Publication date: 2026/02/09
He RonghuanTu XiaoyuLiu BeiJiang ZeyiChen JinLi Jingyi