FLNA predesign siRNA
- Known as:
- FLNA predesign small interfearing RNA
- Catalog number:
- RI12027
- Product Quantity:
- 5 OD
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- FLNA predesign siRNA
Related genes to: FLNA predesign siRNA
- Gene:
- FLNA NIH gene
- Name:
- filamin A
- Previous symbol:
- FLN1, FLN, OPD2, OPD1
- Synonyms:
- ABP-280
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-18
- Date modifiied:
- 2019-04-23
Related products to: FLNA predesign siRNA
Related articles to: FLNA predesign siRNA
- Metastasis is a big challenge for prostate cancer patients that reduces their overall survival from 98.2% to 30%. Therefore, it is important to find the underlying mechanism driving metastasis and find a drug that can prevent cell invasion, migration, and metastasis. Here, we analyzed publicly available expression data of primary and metastasized tissue of Prostate cancer extracted from the GEO database. The obtained Differentially Expressed Genes (DEGs) were used to construct the Protein-Protein Interaction (PPI) and functional networks. These DEGs were enriched in pathways such as blood vessel development, and mesenchyme migration which are involved in the process of Prostate cancer metastasis. The hub genes in the constructed PPI network were subjected to the DrugBank query to find candidate drugs with potential inhibitory effects on metastasis. We found that Artesunate can target three hub genes: CSRP1, FLNA, and TPM1. Finally, we validate this finding by in vitro assessments on the LNCaP cell line. We observed that 2.5 mg/ml Artesunate in the scratch assay reduced the scratch closure rate by about 50% compared to the control in 48 h. These findings suggest that Artesunate may be a promising therapeutic agent for inhibiting prostate cancer metastasis. - Source: PubMed
Publication date: 2026/05/21
Saadat ZakieAhmadi Seyed MahdiBazyari Mohammad JavadAghaee-Bakhtiari Seyed Hamid - The epicardium provides essential cellular and molecular cues required for proper cardiogenesis and cardiac repair. Epicardial-derived cells (EPDCs) play a pivotal role in establishing cardiac structure, contributing to coronary vasculature formation, connective tissue organization, and post-ischemic cardiac remodeling. During EPDC emergence, the epicardium must preserve a precise balance between cellular motility and epithelial integrity. However, the mechanisms determining why some epicardial cells undergo epithelial-to-mesenchymal transition to become EPDCs while others retain an epithelial state remain unclear. We show that miR-200b is expressed in a subset of epicardial cells during embryonic EPDC formation. Gain-and loss-of-function experiments reveal that miR-200b regulates the overall number of EPDCs by modulating the proportion of symmetric and asymmetric cell divisions. RNA pull-down coupled with RNA-seq, together with in vitro and ex vivo functional assays, identified filamin A (FLNA)-a key regulator of spindle positioning during asymmetric division-as a direct miR-200b target in epicardial cells. FLNA loss reduced asymmetric divisions, supporting its role in promoting this division mode. Overall, our study defines a miR-200b-FLNA axis that governs symmetric versus asymmetric division to control epicardial tissue dynamics during cardiogenesis. Additionally, altered miR-200b expression after myocardial infarction in mice and humans suggests a potential role post-MI. - Source: PubMed
Publication date: 2026/05/26
Sánchez-Fernández CristinaGarcía-Padilla CarlosLozano-Velasco EstefaníaHernandez-Torres FranciscoOcaña ÓscarQuintas AnaVázquez EnriqueAlonso-Herranz LauraRicote MercedesRomán-Payan BeatrizCarmona RitaFranco DiegoDomínguez Jorge NAránega Amelia E - Filamin A (FLNA) is an actin-binding protein that regulates mechanosensitivity and functions as an intracellular signaling scaffold in various cell types. It has also been implicated in tumor growth. We recently reported FLNA expression in human ovarian granulosa cells and in KGN cells, a granulosa cell tumor (GCT) line. - Source: PubMed
Publication date: 2026/05/20
Jiang YuhaoCaban Karolina MagdalenaPeitzsch MirkoHerrmann CarolaMayr DorisStöckl Jan BerndFröhlich ThomasMayerhofer ArturMüller-Taubenberger AnnetteWelter Harald - Intramuscular fat (IMF) plays an important role in determining meat quality traits such as flavor, tenderness, and juiciness. While numerous studies have investigated the genetic basis of IMF in commercial pig breeds, data on local breeds remain rather limited. In this study, we used RNA-sequencing to characterize the transcriptomic differences between high-IMF and low-IMF Black Slavonian pigs, a native Croatian breed known for superior meat quality. Muscle samples (Longissimus thoracis et lumborum) from 14 pigs with divergent IMF levels were collected shortly after slaughter, preserved in liquid nitrogen, and stored at - 80 °C until RNA extraction. Intramuscular fat content was determined from the same muscle 24 h post mortem using the Soxhlet extraction method (ISO 1443:1973). These samples were then analyzed to identify differentially expressed genes (DEGs) and enriched pathways. A total of 519 genes were differentially expressed (p ≤ 0.05), with 457 remaining significant after false discovery rate correction. The high-IMF group exhibited upregulation of genes associated with lipid metabolism (e.g., SCD, ADIPOQ, CIDEC, FABP4), PPAR signaling, and adipogenesis, while genes linked to muscle structure and oxidative metabolism were downregulated. Functional enrichment and gene set enrichment analyses highlighted coordinated regulation of pathways related to fatty acid biosynthesis, extracellular matrix (ECM) remodelling, angiogenesis, and Notch signaling. Notably, several ECM-related genes (LAMA1, TIMP4) and angiogenic factors (FGF2, NRP1) were significantly upregulated, suggesting that adipocyte expansion in muscle requires parallel vascular and structural adaptations. Importantly, several of the top 30 DEGs, including EHD2, NRG4, UTRN, FLNA, and HMCN1, represent novel candidate genes not previously linked to IMF in pigs, pointing to potential breed-specific mechanisms. These genes are associated with membrane trafficking, paracrine signalling, cytoskeletal re-modelling, and ECM dynamics. Our findings contribute new molecular insights into IMF regulation in local pig breeds and provide a foundation for developing targeted breeding strategies to improve pork quality through intramuscular fat enhancement. - Source: PubMed
Publication date: 2026/05/20
Lukic BorisLipavić GoranBulaić MatejaIno CurikRadišić ŽarkoLužaić RasRaguž Nikola - Diabetic retinopathy (DR) is a major cause of severe visual impairment, where early diagnosis and intervention are crucial to prevent irreversible damage. Given that obtaining biomarkers from ocular fluids is highly invasive, we here leverage bioinformatic approaches to identify novel biomarkers and potential therapeutic drugs in the peripheral blood of patients with DR. - Source: PubMed
Publication date: 2026/05/14
Chen DiWu GuanrongLiao ShuoxinZhu HaoxianLi FangfangLiu ChangZhao HongyueMeng QianliFang Xiang