SERPINA3 Antibody (Center)
- Known as:
- SERPINA3 Antibody (Center)
- Catalog number:
- AP7314c
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- SERPINA3 Antibody (Center)
Related genes to: SERPINA3 Antibody (Center)
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 Antibody (Center)
Related articles to: SERPINA3 Antibody (Center)
- Alzheimer disease (AD) and Postoperative delirium (POD) may share a common mechanism, but their shared genes and potential novel therapeutic targets remains unknown. We selected datasets GSE48350, GSE4226, and GSE16759 containing AD and control samples from the GEO database for AD model development, and use the GSE63061 dataset for AD model validation. The GSE163943 dataset containing PODs and controls was used to identify common genes. Differentially expressed genes (DEGs) associated with POD and AD respectively, as well as common DEGs between 2 diseases were analyzed. Shared DEGs were assessed using gene ontology and KEGG enrichment and PPI interaction networks. Machine learning algorithms, nomogram and decision tree analyses were used to interpret top 5 genes and visualize the models. 259 DEGs in POD with 148 being up-regulated and 111 down-regulated, and 199 DEGs in AD with 25 up-regulated and 174 down-regulated were found, of which 23 were common to POD and AD. Gene ontology analysis indicated that DEGs were primarily concentrated in 9 distinct biological processes, while KEGG results revealed 3 major metabolic pathways. Five hub genes emerged as potential diagnostic biomarkers for both diseases, Bruton tyrosine kinase (BTK), NCF2, CRH, FCGR3A, and SERPINA3. The LASSO model determined that the 23 common genes could serve as biomarkers for both POD and AD patients, and the Random Forest model is the the most suitable model. POD or AD decision trees showed BTK and NCF2 were sufficient to distinguish between POD or AD patients and healthy controls. BTK and NCF2 were identified common biomarkers of POD and AD. Further investigations are required to verify correlations between gene expression levels and pathological characteristics. - Source: PubMed
Fang YiqiZhang XiaoZhan Gaofeng - Neuroblastoma (NB) is one of the most common malignant tumors in children. Despite intensive multimodal treatments, patients with high-risk NB still have a poor prognosis; therefore, early identification of high-risk patients based on reliable NB biomarkers is essential. Endoplasmic reticulum (ER) stress has been demonstrated to play a vital role in cancer biology; however, it is unclear whether ER stress-related genes are involved in NB and should be further explored as new potential diagnostic and prognostic targets. - Source: PubMed
Publication date: 2026/03/24
Lu WentingZhou RuixiYue YanYing JunjieXiong TaoTang JunShi JingWang HuaZhang LiRuan Tiechao - Tamoxifen (TAM) resistance remains a challenge in estrogen receptor-positive breast cancer treatment. Current research suggested that mesenchymal stem cells (MSCs) derived exosomes may mediate chemoresistance, but the underlying mechanisms are unclear. This study investigates how exosomes from tamoxifen-pretreated MSCs (Tt-MSC-exos) promote tamoxifen resistance through the miR-137/SERPINA3 axis. - Source: PubMed
Publication date: 2026/05/21
Huang XiaolanLi TingtingYe ShiqianLan YananZeng LinLiu Yan - Major depressive disorder (MDD) in adolescents lacks objective peripheral biomarkers that may assist diagnosis and biological stratification. Serine protease inhibitor A3 (SERPINA3) is an inflammation-related acute-phase protein, but its circulating levels and clinical relevance in adolescent MDD remain unclear. - Source: PubMed
Publication date: 2026/05/20
Xue YongFan Gui MeiWang YueDong HuiWei Chun HongZhang Bo - Lung cancer remains the leading cause of cancer-related mortality, with poor outcomes driven by late presentation and therapy resistance. Although genes encoding secreted proteins may reflect tumor biology and have biomarker potential, systematic multi-cohort studies identifying and validating prognostically relevant secreted-protein candidates in non-small cell lung cancer (NSCLC) are limited. - Source: PubMed
Publication date: 2026/05/18
Kim JoonLee GeuninYong Seung-HyunKim Eun YoungJo YunjuJeong WoojuRyu DongryeolOh Chang-MyungLee Sang Hoon