TFAP2A Antibody (C_term)
- Known as:
- TFAP2A Antibody (C_term)
- Catalog number:
- AP1976b
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- TFAP2A Antibody (C_term)
Related genes to: TFAP2A Antibody (C_term)
- Gene:
- TFAP2A NIH gene
- Name:
- transcription factor AP-2 alpha
- Previous symbol:
- TFAP2, AP2TF
- Synonyms:
- AP-2
- Chromosome:
- 6p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-12
- Date modifiied:
- 2016-04-06
Related products to: TFAP2A Antibody (C_term)
Related articles to: TFAP2A Antibody (C_term)
- Clear cell renal cell carcinoma (ccRCC) is the most common renal carcinoma subtype. Aging-related genes (ARGs) are implicated in ccRCC progression, though their mechanisms remain unclear. This study aimed to elucidate the molecular mechanisms of ARGs in ccRCC and identify potential prognostic biomarkers and therapeutic targets. Transcriptomic data from the cancer genome atlas (TCGA-ccRCC) cohort were analyzed. differentially expressed genes and ARGs were intersected to identify candidate genes. Prognostic ARGs were then screened using machine learning algorithms. A risk model was constructed and validated through survival analysis, stratifying patients into high- and low-risk groups. Functional enrichment, immune infiltration, and drug prediction analyses were performed. The expression levels of prognostic genes in ccRCC tissues were validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR). A total of 2312 differentially expressed genes and 307 ARGs were identified, of which 25 overlapping genes were selected as candidates. Seven ARGs were significantly associated with patient prognosis: protective PCK1, and risk-related TOP2A, TFAP2A, CCNA2, FOXM1, CDKN2A, and PLAU. High-risk patients showed reduced overall survival rates. Immune infiltration and checkpoint expression differed significantly between risk groups. decision curve analysis indicated high clinical utility. Drug prediction identified 69 potential therapeutic compounds, including tyrosine kinase and mTOR inhibitors. RT-qPCR validated 5 genes' expression, consistent with bioinformatics predictions, though discrepancies were observed in the expression patterns of FOXM1 and CDKN2A. Seven ARGs were identified as key prognostic markers in ccRCC. A robust risk model was established, providing insights into ARG-related mechanisms and potential diagnostic and therapeutic strategies. - Source: PubMed
Liu ChenShuang WeibingCao XiaomingGao Ying - The oncogenic roles of microRNAs have been extensively documented across various cancer types. In the present study, we aimed to investigate the functional impact of miR-135a-5p on the clear cell renal cell carcinoma (ccRCC) cell line 769P. Through weighted gene co-expression network analysis (WGCNA), we identified a significant association between miR-135a-5p and ccRCC progression. Furthermore, miR-135a-5p expression was downregulated in both ccRCC tissues and cell lines. Functional assays demonstrated that miR-135a-5p inhibits the progression of 769P cells. Mechanistically, miR-135a-5p directly binds to the 3' untranslated region (3'UTR) of TFAP2A, reducing its mRNA stability. In turn, TFAP2A binds to the promoter region of KRT8 and activates its transcription, thereby mediating the inhibitory effect of miR-135a-5p on 769P cell progression. In conclusion, our findings provide evidence that miR-135a-5p suppresses ccRCC progression in 769P cells through the TFAP2A/KRT8 axis, highlighting its potential as a therapeutic target for ccRCC. - Source: PubMed
Publication date: 2026/05/08
Xie DelongZhou JizheGuo YueyueWan GuangyangLu FeiyanGuo YuyingYi SanguiLiu Zongling - Long-term exposure to low-dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight-of-evidence computational model, which predicted 127 chemicals to be of high concern. From these, we selected 7 chemicals-representing both high and low concern categories-and evaluated their potential embryotoxicity using the mouse embryonic stem cell test (mEST). Among the selected chemicals, thiram most strongly inhibited cardiac differentiation in mEST. We further examined the effects of thiram on morphology and expression of differentiation-related genes in mouse embryonic stem cells (mESCs). Treatment with thiram inhibited 50% early differentiation in mESCs, suppressed the expression of markers associated with the three-germ layers, but increased the expression of neurectoderm markers during early embryogenesis. Additionally, treatment with 20 ng/mL thiram, which was the lowest-observed-effect concentration of cytotoxicity, disrupted neuronal differentiation in both mESCs and human pluripotent embryonal carcinoma NT2 cells. Finally, based on transcriptome analysis, 20 and 30 ng/mL thiram disrupted the neural crest differentiation pathway, altering the expression of genes including homeobox A1 (HOXA1), homeobox B1 (HOXB1), Heart And Neural Crest Derivatives Expressed 1 (HAND1), Distal-Less Homeobox 5 (DLX5), and transcription factor AP-2 alpha (TFAP2A) in NT2 cells. Therefore, disruption of neural crest differentiation is one of the potential mechanisms underlying thiram-induced embryotoxicity. The integrated alternative approach adopted in the present study to identify mechanism-based biomarkers for thiram-induced embryotoxicity in a human-relevant model could facilitate safety assessment for data-poor chemicals in future. - Source: PubMed
Publication date: 2026/04/21
Ho Chia-ChiTung Chun-WeiYen B LinjuWeng Chen-YiHsu Ju-HsinTsai Ming-HsienArrokhman SalimLin Pinpin - Understanding the factors that shape population genetic structure is crucial for advancing evolutionary studies and developing effective management and conservation strategies. The northern pike (Esox lucius L.) is a top teleost predator that inhabits fresh and brackish water environments in the northern hemisphere. Pike populations in the brackish Baltic Sea typically display strong genetic structuring, with coastal sympatric populations that separate during spring for spawning in either shallow, sheltered brackish bays or in freshwater tributaries and wetlands. In contrast to the Baltic Sea, genomic structuring in freshwater environments, particularly in large lacustrine systems, remains poorly understood. To address this gap, we used restriction site-associated DNA-sequencing to assess the genetic structure and diversity of northern pike in two ecologically contrasting habitats: freshwater Vänern Lake, Sweden (8932 single nucleotide polimorphisms [SNPs]), and the brackish Baltic Sea around Saaremaa, Estonia (6899 SNPs). The results show strong genetic structuring and lower genetic diversity in brackish environment compared to the higher genetic diversity and extremely low genetic structuring observed in freshwater habitat. We found no evidence of divergent selection within environments. However, we identified 187 outlier SNPs and 62 outlier genes distinguishing the brackish and freshwater environments, potentially reflecting adaptation to salinity. Notably, several of these genes are associated with key biological processes, including osmotic stress regulation (akap13), early development (tfap2a) and pathogens response (tlr18). From a fisheries management perspective, our results indicate that the freshwater system can be managed as a single stock, while strong population structuring among Baltic coastal pike likely requires either large-scale solutions and/or population-specific fine-scale management efforts to maintain the genetic and life-history diversity among brackish coastal pike populations. - Source: PubMed
Publication date: 2026/03/30
Diaz-Suarez AlfonsoLópez María-EugeniaSundblad GöranVasemägi Anti - To explore the role of ferroptosis in the process of corneal epithelial repair and to elucidate the underlying molecular regulatory mechanisms. - Source: PubMed
Publication date: 2026/03/23
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