SLC11A1 Antibody (Center) Blocking Peptide
- Known as:
- SLC11A1 Antibody (Center) Blocking Peptide
- Catalog number:
- BP8514c
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Abgen
- Gene target:
- SLC11A1 Antibody (Center) Blocking Peptide
Related genes to: SLC11A1 Antibody (Center) Blocking Peptide
- Gene:
- SLC11A1 NIH gene
- Name:
- solute carrier family 11 member 1
- Previous symbol:
- LSH, NRAMP, NRAMP1
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-21
- Date modifiied:
- 2016-02-17
Related products to: SLC11A1 Antibody (Center) Blocking Peptide
Related articles to: SLC11A1 Antibody (Center) Blocking Peptide
- Myocardial ischemia-reperfusion (MIR) injury remains the leading cause of adverse outcomes after myocardial infarction, and its prevention remains a major therapeutic challenge. - Source: PubMed
Publication date: 2026/06/19
Dong YilinYang HaomingYang FanMeng Liang - Ferroptosis is a critical contributor to cardiomyocyte injury in acute myocardial infarction (AMI). This study aimed to identify key ferroptosis-associated genes and elucidate their roles in AMI. Transcriptomic datasets from AMI patients and healthy controls were analyzed to identify differentially expressed genes (DEGs). The role of the solute carrier family 11 member 1 (SLC11A1) was validated in vitro using a hypoxia/reoxygenation (H/R) model in H9c2 cardiomyocytes and in vivo using a murine AMI model. SLC11A1 expression was elevated in H/R-treated cardiomyocytes and infarcted murine hearts. SLC11A1 silencing reduced infarct size and improved cardiac function, and suppressed ferroptosis. Mechanistically, SLC11A1 led to the transcriptional suppression of glutathione peroxidase 4 (GPX4) mediated by the transcription factor specificity protein 1 (Sp1). This study identifies the SLC11A1-Sp1-GPX4 axis as a pivotal transcriptional regulator pathway driving ferroptosis in AMI. These findings highlight SLC11A1 as a promising therapeutic target in AMI. - Source: PubMed
Publication date: 2026/06/03
Zhang ShirongWang YeshuFeng YangmeiWang FangZhu Jiaqing - Given its high mortality and broad societal impact, the COVID-19 pandemic is arguably one of the most consequential public health crises of the twenty-first century. Although previous studies have identified several genes associated with COVID-19 susceptibility, relatively little is known about the genes contributing to severe COVID-19, including their evolutionary histories. In the current study, we analyzed IL-4, TLR2, CCL2, and SLC11A1-immunity genes that have previously been implicated in severe COVID-19 and other immune-related diseases-in globally diverse populations from the 1000 Genomes Project. We also tested for associations between genetic variation at these genes and clinical COVID-19 phenotypes in nearly 4000 laboratory-confirmed COVID-19-positive individuals across two datasets from the GEN-COVID Multicenter Study in Italy. - Source: PubMed
Publication date: 2026/05/29
Cross Christopher NLisi AlessandroSimmonds Faith CFlores Marisol FerminWashington KareemHeinbockel ThomasCampbell Michael C - Pleural tuberculosis is one of the most frequent extrapulmonary manifestations of infection and is characterized by a pronounced immune-mediated response with a low bacillary burden. Host genetic factors appear to play a central role in its immunopathogenesis. - Source: PubMed
Publication date: 2026/05/02
Neto André AmateOlivo Taylor Endrigo ToscanoMastroianni Patríciade Nadai Mariane NunesForgerini Marcelade Nadai Tales Rubens - Mucinous colorectal adenocarcinoma (MAC) is characterized by poor prognosis and therapy resistance, yet its molecular and tumor microenvironment (TME) features remain inadequately understood, limiting the identification of effective therapeutic targets. Here, we performed a comprehensive analysis of MAC tumor characteristics and the TME using large-scale genetic and transcriptomic sequencing datasets. Our findings reveal that MAC tumor cells harbor a higher frequency of canonical mutations yet exhibit lower chromosomal instability. Additionally, we observed an increased infiltration of natural killer (NK) cells and highly expressed macrophages (Mac-SPP1) within the TME, along with heightened fibroblastic and myeloid inflammatory signals. Mac-SPP1, characterized by M2 macrophages, was associated with poor prognosis. Furthermore, we identified key prognosis-related genes, including , , and , and proposed potential therapeutic agents for overcoming treatment resistance. Our findings offer valuable insights into the molecular mechanisms underlying MAC and highlight the critical need for novel therapeutic strategies. - Source: PubMed
Publication date: 2026/03/30
Li JianxiaFu YangBai FanWu ZehuaQin GeDeng Yanhong