SOX9
- Known as:
- SOX9
- Catalog number:
- NBP1-36509
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SOX9
Related genes to: SOX9
- Gene:
- SOX9 NIH gene
- Name:
- SRY-box 9
- Previous symbol:
- CMD1, CMPD1
- Synonyms:
- SRA1
- Chromosome:
- 17q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-25
- Date modifiied:
- 2018-06-25
Related products to: SOX9
Related articles to: SOX9
- Chronic inflammation and impaired immune microenvironment are key barriers to effective cartilage regeneration. Herein, we developed an integrated, injectable thermosensitive hydrogel system termed CS@Gel-Mg. This system modularly combines exosome-loaded chitosan microspheres (CM@Exo) embedded within a Mg-coordinated poly(N-isopropylacrylamide)-based ionic liquid hydrogel (Gel-Mg), aiming to modulate local immune response and promote cartilage repair. - Source: PubMed
Publication date: 2026/06/23
Xiong LiChai BinKuang GaixiaKaneko YosukeZhang GonghaoJi Yunhan - Due to the extremely limited intrinsic regenerative ability of cartilage, the repair of articular cartilage defects remains a major clinical challenge at present. Here, through the Schiff-base crosslinking between chitosan and gelatin, reinforced with Sr, an injectable and rapidly gelling composite hydrogel - loaded coaxial electrospun staple fiber was developed. The embedded fibers bridge adjacent pores to form a layered ECM simulation structure, enhancing structural stability, cell adhesion, and local microenvironment regulation. The hydrogel exhibited rapid gelation and obvious shear thinning behavior within 30 s, realizing minimally invasive injection. The encapsulation of Sr within coaxial fibers effectively suppressed initial burst release and achieved sustained ion release for 30 days, with a cumulative release of approximately 60%. In vitro, the composite hydrogel showed good biocompatibility, promoted the proliferation and migration of bone marrow mesenchymal stem cells, enhanced the early cartilage related matrix deposition, and reduced the expression of pro-inflammatory cytokines in LPS stimulated macrophages. In the rat full-thickness cartilage defect model, the sustained release hydrogel showed improved defect filling and hyaline-like cartilage repair at 8 weeks, accompanied by Safranin O staining and significantly increased COL-II and SOX-9 expression. This work may provide an effective strategy for promoting cartilage repair in vivo through the long-term release of biological factors using functional biomass materials. - Source: PubMed
Publication date: 2026/07/13
Zeng JiyangLi WeiDai YuliangLi YaweiMa HongTu ZhimingYuan TaoWang BingDeng Hongbing - Kartogenin (KGN) is a potent inducer of chondrogenic differentiation, but its biomedical application is limited by poor aqueous solubility and the lack of efficient delivery systems. In this study, hybrid nanosystems composed of KGN-loaded liposomes (LK) coated with amphiphilic hyaluronic acid (HA) derivatives were developed to combine favorable carrier properties with HA-mediated biological targeting. Native HA was hydrophobically modified with dodecyl (C12) or octadecyl (C18) chains at low or high degrees of substitution (DS), yielding three amphiphilic derivatives: HAC12L, HAC18L, and HAC18H. Polymer-coated liposomes were characterized by dynamic light scattering and ζ-potential measurements, while lipid bilayer organization was evaluated by differential scanning calorimetry (DSC) and cryogenic transmission electron microscopy (cryo-TEM). Increasing hydrophobic modification enhanced polymer-liposome association and altered liposome surface organization. HAC18H provided the strongest KGN retention but also introduced greater membrane heterogeneity. All HA derivatives exhibited good cytocompatibility toward human umbilical cord Wharton's jelly mesenchymal stem cells (hUC-MSCs) within the concentration range of 1-40 µg/mL, and polymer coating reduced the cytotoxicity of KGN-loaded liposomes compared with uncoated systems. In a 14-day stimulation model, the hybrid formulations induced structure- and dose-dependent upregulation of chondrogenic markers (SOX9, ACAN, COL2A1) with minimal induction of COL1A1, consistent with activation of early chondrogenic differentiation pathways. Among the tested systems, LK-HAC18L exhibited the most balanced chondrogenic profile, as assessed by combined gene expression, lineage specificity, and CD44 receptor engagement. Overall, these findings indicate that controlled hydrophobic modification of HA modestly modulates KGN release behavior while influencing its biological activity, providing a promising platform for cartilage regeneration applications. - Source: PubMed
Publication date: 2026/07/09
Wytrwal MagdalenaOclon EwaRzepa SylwiaPardyak LauraFilipek KatarzynaKucharski MiroslawGórniewicz-Lorens MagdalenaSzczubiałka Krzysztof - Osteoarthritis (OA) involves chronic inflammation and oxidative stress, both of which impair cartilage regeneration. To counteract these pathological processes, bone marrow mesenchymal stromal cell (BMSC)-derived exosomes have emerged as a promising therapy. These exosomes promote chondrogenesis and facilitate chemokine-guided cell homing. However, hostile microenvironments compromise their efficacy. This study developed a cell-free, ROS-responsive boronate-vinyl (BV) hydrogel platform encapsulating BMSC-derived exosomes overexpressing CircSERPINE2 (BV@cSERPINE2-Exo), which were isolated via ultracentrifugation from lentivirus-transduced BMSCs. This platform enables sustained microenvironmental modulation and functional cartilage regeneration. The hydrogel forms through dynamic boronate ester crosslinking between phenylboronic acid-modified poly γ-glutamic acid and polyvinyl alcohol (PVA). It exhibits rapid gelation, shear-thinning injectability, and potent ROS-scavenging capacity. ROS-triggered cleavage of the boronate ester bonds ensures controlled exosome release. In vitro, BV@cSERPINE2-Exo shifted LPS-stimulated macrophages from an M1 to M2 phenotype by decreasing iNOS and IL-1β levels and increasing Arg-1 and IL-10. Concurrently, the system protected chondrocytes from TNF-α-induced degeneration by downregulating MMP13 and restoring COL2A1, SOX9, and proteoglycan synthesis. In a rat patellar cartilage defect model, intra-articular injection of BV@cSERPINE2-Exo promoted deposition of cartilage-specific extracellular matrix and achieved near-complete hyaline cartilage-like repair within 8 weeks. This repair was superior to that in the BV hydrogel or unmodified exosome control groups. These results establish a smart, injectable biomaterial strategy that integrates precise ROS-responsive circRNA delivery with immunomodulation, offering a promising early intervention strategy for cartilage defect repair and the prevention of osteoarthritis progression. - Source: PubMed
Publication date: 2026/07/01
Zhu MingDai ShiminCui JingquanZhao ZhiboWei XingchenLi PingLi Wei - To investigate the genetic etiology of fetal postural anomalies using whole-exome sequencing (WES) and elucidate the genotype-phenotype correlation between prenatal sonographic findings and molecular signatures. - Source: PubMed
Publication date: 2026/07/09
Qin YayunWang TingYi MeiqiLi HuiZeng LingLiu LijunSong Jieping