APOO (2F1 )
- Known as:
- APOO (2F1 )
- Catalog number:
- NBP1-28870
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- APOO (2F1 )
Related genes to: APOO (2F1 )
- Gene:
- APOO NIH gene
- Name:
- apolipoprotein O
- Previous symbol:
- FAM121B
- Synonyms:
- MGC4825, My025, Mic23, MIC26, MICOS26
- Chromosome:
- Xp22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-11
- Date modifiied:
- 2018-11-16
- Gene:
- CRISPLD1 NIH gene
- Name:
- cysteine rich secretory protein LCCL domain containing 1
- Previous symbol:
- LCRISP1
- Synonyms:
- Cocoacrisp, DKFZp762F133
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-11
- Date modifiied:
- 2017-05-25
- Gene:
- CYP2F2P NIH gene
- Name:
- cytochrome P450 family 2 subfamily F member 2, pseudogene
- Previous symbol:
- CYP2F1P
- Synonyms:
- -
- Chromosome:
- 19q13.2
- Locus Type:
- pseudogene
- Date approved:
- 2002-07-05
- Date modifiied:
- 2015-12-09
- Gene:
- DMKN NIH gene
- Name:
- dermokine
- Previous symbol:
- -
- Synonyms:
- ZD52F10
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2006-06-13
- Date modifiied:
- 2016-04-25
- Gene:
- FAM177B NIH gene
- Name:
- family with sequence similarity 177 member B
- Previous symbol:
- -
- Synonyms:
- RP11-452F19.2, FLJ43505
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-09
- Date modifiied:
- 2016-09-30
Related products to: APOO (2F1 )
Related articles to: APOO (2F1 )
- Dynamics of mitochondrial metabolism are critical to breast cancer (BC) progression, yet the precise regulatory pathways underlying these changes remain incompletely understood. This study aimed to identify mitochondria-related prognostic genes in breast cancer, construct a mitochondria-related riskmodel, and investigate the role of apolipoprotein O (APOO) in lipid metabolic reprogramming and tumor progression. - Source: PubMed
Publication date: 2026/03/19
Sha YupengDu YiNiu MingYuan QuanHan Jiguang - Apolipoproteins (APOs) are essentially structural and functional components of lipoproteins, which are composed of 22 members and their effects on certain types of cancer have been studied. However, their roles in endometrial cancer (EC), which is one of the most common malignant tumors in gynecology were unclear and rarely investigated. - Source: PubMed
Publication date: 2026/02/16
Zhou LinaWang RenchengDu GuiqiangWu YupengLi HuiHe YinyanYe ZhikangXiang Jiangdong - Objective To identify key genes of lipid metabolism in diabetic nephropathy(DN) through machine learning models and animal model validation. Methods The limma R package was used for differential gene expression analysis on 69 samples from two transcriptome datasets of the Gene Expression Omnibus and 2 184 differentially expressed genes were identified.Subsequently,we adopted undifferentiated consensus clustering to classify DN samples into two specific subtypes.At the same time,we performed weighted gene co-expression network analysis to mine the gene modules significantly associated with DN.In addition,using least absolute shrinkage and selection operator,support vector machine-recursive feature elimination,and random forest machine learning techniques,combined with protein-protein interaction network analysis,we screened out three core genes.Finally,we constructed a mouse model of type 2 diabetes mellitus to verify the effectiveness of the expression of these key genes. Results Three core genes,APOO,ALDH7A1,and ALB,were predicted as potential biomarkers of lipid metabolism in DN,and their expression levels were downregulated in DN.Through experimental validation in a diabetic mouse model,we confirmed the altered expression of APOO,ALDH7A1,and ALB in DN,which supported their potential as diagnostic markers. Conclusions Our findings suggest that APOO,ALDH7A1,and ALB are new diagnostic markers associated with lipid metabolism in DN,which provides new perspectives for understanding the molecular mechanisms of lipid metabolism in DN. - Source: PubMed
Li YueZhang Yu-YuWan XingNiu Song-LinShi Hong-HongWang Li-Hua - Primary immune thrombocytopenia involves antibody-driven platelet loss and perturbed CD4 T cell regulation. By integrating single-cell transcriptomic, epigenetic, and functional analyses, we delineated CCR7CD4 T cell states with distinct metabolic and transcriptional programs. A subset enriched in patients exhibited reduced oxidative phosphorylation and enhanced glycolysis, accompanied by elevated expression of SP100 and its downstream transcriptional targets FOXP1 and CDK6. Trajectory analysis positioned these cells as developmentally arrested intermediates that, in normal individuals, mature into CCR7 cells expressing apolipoprotein O (APOO). Functional perturbations revealed that APOO preserves oxidative metabolism and CCR7 identity while restraining SP100-dependent transcription. Methylation profiling identified APOO hypermethylation and transcriptional silencing in patient-derived CD4 T cells. Together, these data define APOO as a metabolic-transcriptional checkpoint governing CCR7CD4 T cell fate, whose repression fosters dysfunctional differentiation and immune imbalance in autoimmune thrombocytopenia. - Source: PubMed
Publication date: 2025/10/16
Li TengdaLi XiangHuang He - In patients experiencing acute heart failure, acute cardiogenic pulmonary edema (ACPE) can emerge due to a surge in pulmonary capillary hydrostatic pressure. This escalation triggers a fluid build-up beyond the lymphatic interstitial drainage system's ability to eliminate, leading to a swift increase in interstitial and alveolar fluid volumes. Such accumulation subsequently results in intrapulmonary shunting and an advancing state of respiratory failure. Contemporary evidence hints at the potential of non-invasive ventilation (NIV) to cut back on the reintubation rate, along with the reduction of ICU and hospital mortality rates, particularly among patients scheduled for extubation. The aim of this review is to critically analyze the existent body of evidence concerning the application of NIV in managing ACPE. It seeks to explore the practical aspects of utilizing NIV within an emergency department environment, addressing crucial considerations such as patient selection, commencement of treatment, monitoring protocols, problem-solving strategies, and weaning processes. In addition, our review will also explore the data available on high flow nasal cannula, a relatively recent therapeutic intervention, discussing its role and effectiveness in treating respiratory insufficiency associated with ACPE. - Source: PubMed
Publication date: 2025/11/06
Adi OsmanApoo Farah NuradhwaKeong Yip YatMiller ElliottRoslan Nurul LianaAlviar Carlos LKasim SazzliAhmad Azma HaryatyTavazzi Guido