BCL2L11
- Known as:
- BCL2L11
- Catalog number:
- GTX106413
- Product Quantity:
- 100 µl
- Category:
- -
- Supplier:
- ACR
- Gene target:
- BCL2L11
Related genes to: BCL2L11
- Gene:
- BCL2L11 NIH gene
- Name:
- BCL2 like 11
- Previous symbol:
- -
- Synonyms:
- BOD, BimL, BimEL, BimS, BIM
- Chromosome:
- 2q13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-10
- Date modifiied:
- 2019-04-23
Related products to: BCL2L11
Related articles to: BCL2L11
- Acute lymphoblastic leukemia (ALL) is a clinically diverse cancer in which microRNA (miRNA)-mediated post-transcriptional regulation contributes to leukemogenesis and subtype heterogeneity. In this study, miRNA expression profiling by microarray was performed on ALL cases (B-ALL and T-ALL) and healthy controls. Data were normalized and analyzed for differential expression using false discovery rate (FDR)-adjusted -values. Differentially expressed miRNAs were further examined using unsupervised visualization to assess overall disease-related expression patterns. To explore their biological significance, experimentally validated miRNA-target interactions were obtained using multiMiR, limited to validated databases (miRTarBase, TarBase, and miRecords) and summarized via target-burden ranking, miRNA-target network analysis, and Circos-style interaction mapping. A unique miRNA expression signature was identified in ALL. Upregulated miRNAs included miR-106a-5p, miR-106b-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-181b-5p, and miR-128-3p, while miR-127-3p, miR-139-5p, miR-433-3p, and miR-584-5p were downregulated. Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2. KEGG pathway analysis highlighted pathways associated with leukemic cell survival and growth, including MAPK, cell cycle, autophagy, Hippo, ubiquitin-mediated proteolysis, and mTOR signaling pathways. These findings reveal a concise ALL-associated miRNA panel predominantly comprising the miR-17/20/106 family and provide a prioritized set of candidate regulatory networks for subtype-specific validation and functional follow-up studies. - Source: PubMed
Publication date: 2026/04/27
Basingab Fatemah SAlahdal HadilAlwadaani DeemahAlmuneef GhaidaBarefah Ahmed SAlgiraigri Ali HHammad RawanElnakeeb MohamedAlrahimi Jehan SZaher Kawther AAldahlawi Alia M - Circular RNAs (circRNAs) exhibit significant sex- and development stage-specific expression patterns in the gonads of various fish species, yet their functions and regulatory mechanisms in male reproductive development remain largely unexplored in crucian carp (). In this study, we characterized the expression features and biological functions of circSPEF2, a circular RNA derived from the reproduction-related gene . Our results showed that circSPEF2 expression was markedly elevated in mature testes and progressively upregulated during gonadal maturation. Functional studies suggested that circSPEF2 likely does not act through a ceRNA-dependent mechanism. Transcriptome sequencing following circSPEF2 overexpression identified 45 upregulated and 70 downregulated differentially expressed genes, with GO and KEGG enrichment analyses revealing significant alterations in multiple gonadal development-related genes and signaling pathways. Subsequent siRNA-mediated knockdown of circSPEF2, combined with qRT-PCR validation, confirmed that circSPEF2 positively regulates the expression of genes associated with cell maturation and differentiation, including , , and , while concurrently suppressing that of proliferation- and apoptosis-related genes such as , , and . Furthermore, RNA pull-down combined with mass spectrometry identified three candidate circSPEF2-binding proteins, namely, hnRNP A/B, SRSF2, and CFAP263. Collectively, these findings indicate that circSPEF2 plays an important role in male gonadal development in fish and provide new insights into the post-transcriptional regulatory mechanisms underlying vertebrate male reproduction. - Source: PubMed
Publication date: 2026/04/23
Gou FangGao YanmeiWang RuiZhong DongmeiYang RongLiu Shaojun - Innate immune dysregulation is increasingly recognized as a pivotal contributor to hypertension pathogenesis. However, the role of natural killer (NK) cells, a key innate lymphocyte population, remains poorly defined and controversial. - Source: PubMed
Publication date: 2026/04/16
Wang XiaoqiYang QiaoxiBian JinFan LuyunZhao XueyanCai Jun - B-cell prolymphocytic leukemia (B-PLL) is a rare B-cell neoplasm that presents splenomegaly, lymphocytosis, minimal or absent lymphoadenopathy, at least 55% of prolymphocytes in peripheral blood and a variable clinical course. Complex/composite karyotype and recurrent structural variants (SVs), including TP53 aberrations (mutations/deletion) and MYC abnormalities (translocation or gain) are genetic features typically seen in B-PLL. We applied the genome-wide technology of optical genome mapping (OGM) in 3 cases with B-PLL, finding multiple genomic aberrations, including SVs, copy number variations (CNVs) and aneuploidies. MYC aberrations were not observed in our cases, whereas all B-PLL showed concomitant deletion 17p and TP53 mutations. TP53-disrupted B-PLL cells showed additional genomic alterations that affect genes implicated in extrinsic and intrinsic apoptotic pathways i.e., TNFRSF10, FAS, MDM2, BCL2, and BCL2L11 and genes involved in cell-cycle regulation i.e., IKBKB, CDK2, CDK4, and RB1, suggesting that a convergent multifactorial pathogenetic mechanism may be involved in B-PLL. Applying the OGM technology on cytogenetically complex rare hematological neoplasia may be useful to improve the genetic definition and differential diagnosis of B PLL/SBLPN and related splenic B cell neoplasms. - Source: PubMed
Publication date: 2026/04/15
Maffei RossanaPaolini AmbraConte BenedettaBonamici LiaGiorgi SilviaMartinelli SilviaGiacobbi FrancescaCorradini GiorgiaPilato FloraDebbia GiuliaAtene Claudio GiacintoMorselli MonicaPotenza LeonardoGiusti DavideColaci ElisabettaBettelli FrancescaBresciani PaolaCuoghi AngelaGilioli AndreaMesserotti AndreaPioli ValeriaMaccaferri MonicaLeonardi GiovannaForghieri FabioLuppi MarioMarasca RobertoTagliafico Enrico - Colorectal cancer (CRC) remains a leading cause of cancer-related mortality. Plantaricin BM-1, a class IIa bacteriocin from Lactobacillus plantarum, exhibits anticancer potential, but its efficacy against CRC is unclear. - Source: PubMed
Publication date: 2026/03/30
Zheng XuanWang QiSong XiaodongZhu JingxinDai ChunyuJin JunhuaCheng CongyangZhang HongxingXie Yuanhong