SOX6 (780_796)
- Known as:
- SOX6 (780_796)
- Catalog number:
- 28117
- Product Quantity:
- 0.1 mg
- Category:
- Peptides
- Supplier:
- ACR
- Gene target:
- SOX6 (780_796)
Related genes to: SOX6 (780_796)
- Gene:
- SOX6 NIH gene
- Name:
- SRY-box 6
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2015-11-23
Related products to: SOX6 (780_796)
Related articles to: SOX6 (780_796)
- Intervertebral disc (IVD) degeneration, a leading cause of chronic lower back pain, is associated with loss of vacuolated notochordal cells (NCs) and fibrotic remodeling of the nucleus pulposus. Emerging therapies increasingly focus on NCs, which are rare but therapeutically relevant cells for regenerating degenerated IVDs. In this study, we used CRISPR-based transactivation (CRISPRa) to direct the differentiation of human induced pluripotent stem cells (iPSCs) into the NC lineage. We tested CRISPRa-mediated activation of NOTO, TBXT, FOXA2, SOX5, SOX6, and SOX9, coupled with single-cell sequencing of Aggrecan-2A-mScarlet reporter iPSCs. This approach identified the SOX5/6/9 combination (SOX-trio) as critical for promoting NC lineage commitment. The SOX-trio yielded the largest cell population expressing a range of genes previously associated with NC identity, including SHH, FOXA1, FOXA2, FOXJ1, FN1, ALCAM, KRT8, and KRT18. Our study demonstrates the integration of CRISPRa with single-cell technologies as a powerful platform for investigating and enriching iPSC-derived NCs, supporting future regenerative strategies across various fields. - Source: PubMed
Publication date: 2026/08/27
Tong XiaoleVisscher MariekeRiemers Frank MVersluis DanielleGeijsen NielsShang PengTryfonidou Marianna APoramba-Liyanage Deepani W - Cardiac contractility is regulated by two myosin heavy chain (MHC) protein isoforms, and β, encoded by the and genes. The intronic regions of these genes encode the microRNAs and , which are key regulators of cardiac hypertrophy. Functionally relevant long non-coding RNAs (lncRNAs) have also been identified at these loci, such as those transcribed in the antisense direction from the gene, including the primary transcript () originating from an internal promoter. Additionally, , another cardiac sarcomeric myosin gene, serves as a precursor for . - Source: PubMed
Publication date: 2026/08/07
Červenák ZdenkoČervenák FilipValášková SimonaChomaničová NikolaKatreničová NikoletaHulman MichalGažová AndreaKyselovic Jan - The development of the dentate gyrus (DG) of the hippocampus is protracted over time in comparison with other brain regions such as hippocampal cornus ammoni or neocortex, extending over the first postnatal weeks. During DG postnatal development, neural stem cells (NSCs) will remain to generate the adult neurogenic niche that will sustain granule neuron (GN) production throughout life. NSCs in the DG divide to generate intermediate progenitor cells (IPCs), whose highly regulated dynamics of self-renewal or cell cycle exit decisions still remain poorly understood. Sox5 is a transcription factor (TF) essential for the establishment of adult NSCs, however, its potential role in Sox5 expressing IPCs during DG development remains unexplored. In this study, we demonstrate that conditional loss of Sox5 during embryonic development leads to critical alterations in cell proliferation and survival in IPCs. Specifically, following Sox5 loss, IPCs exhibit a shortening of S-phase duration in late postnatal and juvenile adult stages. Furthermore, these alterations in IPC cell cycle dynamics could be behind the defects in GN differentiation observed in Sox5-defective mice that ultimately leads to subtle morphological changes in DG architecture. Finally, we demonstrate that the additional loss of one Sox6 copy, a closely related TF to Sox5, lead to more profound disruptions in DG morphology than the one observed upon Sox5 loss. Overall, these findings point to a prominent role for Sox5 in combination with Sox6 in IPC cell cycle progression and GN maturation during postnatal DG development. - Source: PubMed
Publication date: 2026/07/23
Tirado-Melendro PaulaLi LinglingMedina-Menéndez CristinaJurado-Angulo PilarRodríguez-Martín PilarGarcía-Redondo LauraBilińska KatarzynaMorales Aixa V - The antler primary growth center, located at the distal tip of the growing antler, comprises five consecutive tissue zones beneath the velvet skin. Because the outermost reserve mesenchyme contains blastema progenitor cells with multipotent differentiation capacity, antler regeneration recapitulates embryonic skeletal development through endochondral ossification (ECO). The molecular mechanisms governing cell fate decisions and tissue morphogenesis across these zones remain poorly understood. - Source: PubMed
Publication date: 2026/07/27
Xi XiCao XinyueZhou YuyingTian ZichenHou NanqiLi ZuoyangZhou ZhenweiLi XiangyanSu Hang - Deer antler is the only mammalian organ capable of periodic complete regeneration. Its astonishing growth rate-reaching several centimeters per day-provides a unique model for research in tissue regeneration and developmental biology. This rapid growth relies on the protective and signaling functions of the skin, as well as the vigorous proliferation and differentiation capacity of mesenchymal cells. Although previous studies have identified some key factors involved in antler growth, systematically comparing the transcriptomic profiles of these two core tissues (skin and mesenchyme) to identify candidate genes regulating their synergistic growth is crucial for deciphering the molecular mechanisms underlying this "ultra-fast" growth. - Source: PubMed
Publication date: 2026/07/27
Bi XiaodanLiu BingLi BingZhao MeirongTian HuiminChen Jianxing