CD178 _ Fas Ligand
- Known as:
- CD178 _ Fas Ligand
- Catalog number:
- GTX100644
- Product Quantity:
- 100 µl
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD178 _ Fas Ligand
Related genes to: CD178 _ Fas Ligand
- Gene:
- FASLG NIH gene
- Name:
- Fas ligand
- Previous symbol:
- APT1LG1, TNFSF6
- Synonyms:
- FasL, CD178
- Chromosome:
- 1q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-09
- Date modifiied:
- 2019-04-23
Related products to: CD178 _ Fas Ligand
&_945;2&_946;1 Integrin Ligand Peptide(1R,2R)_(+)_1,2_Diaminocyclohexane_N, min. 94%rost ligand (na(1S,2S)_(+)_1,2_Cyclohexanediamino_N, (S,S)_Jacobsen ligand(1S,2S)_(_)_1,2_Diaminocyclohexane_N,N min. 94% rost ligand (n(1S,2S)_(_)_1,2_Diaminocyclohexane_N,N Rost ligand24(S)-Hydroxycholesterol Ligand24(S)-Hydroxycholesterol Ligand24(S)-Hydroxycholesterol, LXR ligand, (3β,24S)-Cholest-5-ene-3,24-diol, CAS: 474-73-724(S)-Hydroxycholesterol, LXR ligand, (3β,24S)-Cholest-5-ene-3,24-diol, CAS: 474-73-72B4,CD244,h2B4,Homo sapiens,Human,NAIL,Natural killer cell receptor 2B4,NK cell activation-inducing ligand,NK cell type I receptor protein 2B4,NKR2B42C101 Fas Ligand2R2 Fas3.22 Fas- FITC labeled3.22 Fas-PE labeled3D5 Fas Death Domain Related articles to: CD178 _ Fas Ligand
- Colorectal cancer (CRC) remains a major global health burden, while current therapeutic strategies are often constrained by limited efficacy and adverse side effects. This study evaluated the anticancer activity and DNA-binding properties of a novel platinum-Mesalazine complex (Pt-MES) compared with Mesalazine (MES) in human CRC cells. Cytotoxicity was assessed using the MTT assay, gene expression was analyzed by qPCR, and drug-DNA interactions were investigated through viscosimetry, UV-visible spectroscopy, and molecular docking. Both compounds exhibited dose-dependent cytotoxicity; however, Pt-MES demonstrated superior antiproliferative activity, with a lower IC₅₀ value (2.694 µg/mL) than MES (3.503 µg/mL), indicating enhanced efficacy following platinum complexation. Gene expression analysis revealed that Pt-MES promoted apoptosis by upregulating FASLG, BAX, and miRNA-122, while suppressing Bcl-2, telomerase, and miRNA-21. In contrast, MES exerted weaker regulatory effects on these molecular targets. Biophysical studies showed a slight reduction in DNA viscosity accompanied by hyperchromic shifts in UV-visible spectra, suggesting a predominantly non-intercalative mode of DNA interaction. Molecular docking further supported preferential binding within the DNA minor groove. These findings indicate that Pt-MES may interact with DNA grooves and facilitate platinum coordination with nucleophilic sites, particularly guanine residues, leading to DNA structural perturbation and activation of apoptotic pathways. In addition, Pt-MES may influence key pathways implicated in CRC progression, including NF-κB, Wnt/β-catenin, and COX-2 signaling. Collectively, the results demonstrate that Pt-MES exhibits enhanced in vitro anticancer activity relative to MES and represents a promising multi-targeted candidate for further preclinical investigation in colorectal cancer. - Source: PubMed
Publication date: 2026/08/09
Ghasemi KimiyaSabokrouh AbdolrezaNoohi BahareModarresi Farrokh - - Source: PubMed
Tang MingxiangPan HongweiZheng ZhaofenGuo YinPeng JianqiangYang JunLuo YangpingHe JinYan SulanWang PengZhang YiZhou Yulu - Transcriptome analysis relies on intact RNA, and RNA integrity relies on intact cells. Death and cardiac arrest cause hypoxia and result in cell death and RNA fragmentation. Our study aims to systematically define the organ-specific post-mortem intervals (PMIs) at which RNA fragmentation has reached a level that hampers transcriptome analysis and at which apoptosis marker gene expression starts and reaches its maximum. A total of 453 biopsies were harvested from nine organs of seven body donors at 8, 10, 12, 18, and 24 hrs (h), and in four of them also at 6 h after confirmed death. From the livers, two biopsies were harvested. The material was used for calculating the percentage of RNA fragments > 200 nucleotides (DV200) and for determining the expression levels of marker genes of the intrinsic (BAX; CASP9) and extrinsic (FADD; FASLG; CASP8) apoptosis pathways. Additional material was collected from all organs and used for preparing histological sections. These were checked for pathologies. Detailed DV200 values and details of the expression levels of the selected genes of both apoptotic pathways are provided for each time point and organ. The DV200 and apoptosis marker expression levels of the different liver segments were almost identical. Our findings characterize post-mortem RNA fragmentation and the dynamics of apoptotic marker gene expression in nine organs. They define the time frame during which material harvested from these organs can be successfully used for transcriptomics projects, such as the Human Cell Atlas and similar programs. - Source: PubMed
Publication date: 2026/07/06
Baghrsad Sara SamanianMoghaddam Atieh SeyedianPruidze PaataHainfellner AndreasGeyer Stefan HWeninger Jeremias TBauer Stefan AMallik AromitaWeninger Wolfgang J - This study characterizes the acute exercise-induced remodeling of the whole-blood transcriptome and inferred immune microenvironment in pediatric and adolescent patients with sickle cell anemia (SCA). By integrating transcriptomic profiling (GEO: GSE244401) with immune cell deconvolution and multi-level regulatory network analyses, we systematically dissected the molecular response to an acute interval exercise challenge. We identified 107 differentially expressed genes (89 upregulated, 18 downregulated) primarily enriched in natural killer (NK) cell cytotoxicity, T cell activation, and antigen presentation pathways. Protein-protein interaction (PPI) network analysis highlighted 16 hub genes (e.g., , , ), whose upregulation significantly correlated with an increased inferred abundance of circulating NK cells and CD8 + T cells, alongside a concomitant reduction in neutrophils and eosinophils. Furthermore, regulatory network analysis implicated master transcription factors (e.g., EZH2, GLIS2) and key miRNAs (e.g., miR-21-5p, miR-130b-3p) in coordinating these acute cytotoxic responses through target genes such as and . In conclusion, acute exercise triggers a rapid remodeling of the immune landscape, potentially attenuating granulocyte-driven inflammation while activating lymphocyte-mediated immunity. These findings reveal the complex "double-edged" transcriptional responses to exercise in pediatric SCA, providing a critical mechanistic foundation for developing individualized, safely monitored exercise prescriptions. - Source: PubMed
Publication date: 2026/06/28
Zhao JiajiaShang HaonanFu ZetingLi HongliTian LihengLi Chunpeng - LARC patients exhibit heterogeneity in their response to total neoadjuvant therapy (TNT). This study aims to screen and identify plasma biomarkers associated with treatment response to TNT in patients with locally advanced rectal cancer (LARC) to predict pathological complete response (pCR). - Source: PubMed
Publication date: 2026/06/08
Zhu ZonglinWen KaizhenZou BaoyiKang YanhuaChen JingqingZhu BinFan LipingHuang Haobo