Eotaxin _ CCL11
- Known as:
- Eotaxin _ CCL11
- Catalog number:
- GTX12459
- Product Quantity:
- 25 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Eotaxin _ CCL11
Related genes to: Eotaxin _ CCL11
- Gene:
- CCL11 NIH gene
- Name:
- C-C motif chemokine ligand 11
- Previous symbol:
- SCYA11
- Synonyms:
- eotaxin, MGC22554
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-24
- Date modifiied:
- 2016-10-05
Related products to: Eotaxin _ CCL11
Related articles to: Eotaxin _ CCL11
- Nasopharyngeal carcinoma (NPC) is associated with aberrant cellular metabolism and interactions between tumor and stromal cells. This study aims to elucidate the role of glycerophospholipid metabolism in NPC, particularly focusing on the interplay between malignant epithelial cells and fibroblasts. - Source: PubMed
Publication date: 2026/05/20
Wang LipingWang DujuanLi ShuangLiu GuohongLi YirongPan Yunbao - Blood biomarkers are central to monitoring disease progression and evaluating treatment responses, yet traditional venipuncture captures a single physiological snapshot in time and becomes burdensome with repeated sampling. Remote blood self-sampling offers a path toward longitudinal, decentralized monitoring, but maintaining protein integrity from draw to analysis remains a critical challenge. Here, we optimized pre-analytical blood collection and stabilization parameters to maintain protein levels at the time of collection for use with remote sampling technology. First, we optimized blood collection time with Tasso remote self-sampling devices to minimize interference from clotting, finding that a 2.5 min collection time best reduces clot formation while collecting enough blood. Next, we found that Protein Plus, a commercial protein stabilizer, limited hemolysis (a metric for stabilizer efficacy) in venous blood for up to 5 days at 25°C-35°C and for 1 day at 40°C. In addition, we optimized the stabilizer volume and acceptable blood volume range for self-sampling as the stabilizer efficacy is impacted by the stabilizer to blood ratio and collection volume can vary with remote self-sampling devices. Finally, we incubated stabilized blood samples collected via Tasso device at 25°C-35°C for 72 h, mimicking a 2-day shipping period. Using a panel of 21 inflammatory proteins, we found that Protein Plus limited intracellular protein release for various proteins (e.g., VEGF-A, CCL11, and IL-8), inhibited protein degradation for CCL2, and enabled minimal hemolysis. These results support Protein Plus as a viable stabilization strategy for remote blood collection technology targeting longitudinal inflammatory protein monitoring. - Source: PubMed
Publication date: 2026/05/29
Cook Sophie RAlizai M YunosTu Wan-ChenRobertson IngridWei XiaofuAdams KarenSu XiaojingThongpang SanittaBerthier ErwinTheberge Ashleigh B - Allergic asthma is predominantly driven by type 2 T helper (Th2)-mediated immune responses. In this study, we investigated the therapeutic potential and mechanisms of kirenol (Kr) in mice with ovalbumin (OVA)-induced asthma and T-cell models. In the asthmatic mouse model, oral administration of 3 mg/kg body weight of Kr significantly alleviated OVA-specific IgE production, airway hyperresponsiveness, and levels of Th2 cytokines (IL-4, IL-5, and IL-13) and chemokines (CCL11 and CXCL1). Additionally, Kr treatment attenuated inflammatory cell recruitment and mucus production in the lungs. A reduction in the Th2-mediated immune response was observed without inducing CD4 T cell apoptosis in Kr-treated mice. Furthermore, the mechanism of the antiallergic effect regulated by Kr was explored in an anti-CD3/CD28-stimulated CD4 T cell model. Kr at 40 μM suppressed T-cell proliferation by arresting cell cycle progression at the G/G phase. Kr decreased the secretion of IL-2 and Th2 cytokines (IL-4, IL-5, IL-10, and IL-13), while minimally affecting a Th1 cytokine (IFN-γ). Moreover, Kr inhibited Th2 polarization by downregulating expression of the Th2 master transcription factor GATA binding protein 3 (GATA3) gene and reduced T-cell activation markers (CD25, CD71, and CD134). A transcriptomic analysis revealed that Kr influenced the expression of immune-related genes that regulate cell activation, cytokine secretion, cell migration, and inflammatory responses in T cells. However, Kr had no significant immunomodulatory effect on OVA (100 μg/mL)-stimulated bone marrow-derived dendritic cells. These findings suggest that Kr effectively regulates CD4 T cell proliferation, activation, and differentiation, highlighting its potential as a treatment for allergic asthma. - Source: PubMed
Publication date: 2026/06/03
Chang Jer-HwaChuang Hsiao-ChiCheng Po-ChingWang Li-ChiehLee Yueh-Lun - In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease monitoring, and prediction of treatment response. - Source: PubMed
Ryser Fabio SMauthe TinaBrühlmann CatrinSoyka Michael BSteiner Urs C - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease characterized by heterogeneous phenotypes and endotypes, necessitating personalized therapeutic strategies. Precision medicine approaches integrating molecular biomarkers may improve treatment selection and disease stratification. In this prospective controlled study, we investigated the tissue-level immunohistochemical effects of oral corticosteroids (OCSs) and topical steroids on the expression of periostin, eotaxin, interleukin-4 (IL-4), transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) in nasal polyp tissue. Sixty-five patients eligible for endoscopic sinus surgery (ESS) were enrolled and divided into two groups: Group 1 (n = 42) received topical steroids combined with oral prednisone (40 mg/day for 7 days preoperatively), whereas Group 2 (n = 23) received topical steroids alone. Immunohistochemical analysis demonstrated a significant reduction in periostin and eotaxin expression in both epithelial and stromal compartments following OCS therapy, accompanied by increased TGF-β expression. No significant differences were observed in IL-4 or TNF-α expression. These findings indicate that short-term OCSs selectively modulate molecular pathways associated with eosinophilic inflammation and tissue remodeling in CRSwNP, supporting biomarker-driven precision medicine strategies. - Source: PubMed
Publication date: 2026/05/19
Radajewski KamilBurduk PawełWierzchowska MałgorzataAntosik PaulinaJóźwicki JakubBurduk JakubGrzanka Dariusz