SOX9
- Known as:
- SOX9
- Catalog number:
- GT15207-100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SOX9
Related genes to: SOX9
- Gene:
- SOX9 NIH gene
- Name:
- SRY-box 9
- Previous symbol:
- CMD1, CMPD1
- Synonyms:
- SRA1
- Chromosome:
- 17q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-25
- Date modifiied:
- 2018-06-25
Related products to: SOX9
Related articles to: SOX9
- CDK4 alterations are common in lung adenocarcinoma, but recent clinical trials only demonstrated modest therapeutic responses to CDK4/6 inhibitors. The mechanism of CDK4/6 inhibitor resistance has not been fully characterized. - Source: PubMed
Publication date: 2026/06/27
Cheung Alvin Ho KwanWong Kit YeeLi Gordon Yuan-HoXie FudaWu QiuqiuYuen Thomas Tin HoHui Pak LamHuang PingmeiLiu XiaoliChen BonanJi FenfenDong YujuanCheng Alfred Sze-LokNg Calvin Sze HangZhang XiangWong Chi ChunYu JunKang WeiTo Ka-Fai - In mammalian sex differentiation, Sox9 expression in undifferentiated gonads determines male development. Sox9 is regulated by multiple enhancers, of which Enh13/mXYSRa is the most critical. Disruption of the GATA4 binding site in Enh13/mXYSRa causes XY sex reversal in the C57BL/6J (B6J) strain, but not in the mixed genetic background of B6J × DBA/2. To clarify the cause of these differences, mice with the same mutation were generated in DBA/2. Homozygous mutants developed as XY males. We hypothesized that the phenotypic differences between strains were due to functional differences of another enhancer. Mice lacking TESCO and carrying a mutation in the GATA4 binding site were generated and analyzed. The mutants developed according to their chromosomal sex despite reduced Sox9 expression. These findings imply that the DBA/2 genetic background contains factors preventing Sox9 expression from falling below the threshold required for male development. Bulk RNA-seq analysis of fetal gonads during sex determination identified strain-dependent differences in intermediate mesoderm development and protease inhibition pathways; the study also revealed that the expression of Sox8 has a redundant role in Sertoli cell differentiation to that of Sox9 in male embryonic gonads. These differences may contribute to the phenotypic variation observed between strains. - Source: PubMed
Tsuchiya IkuTsuji-Hosokawa AtsumiFuruhashi SuzuneSugiyama KarinOgawa YuyaOishi AkiTerao MihoTakada Shuji - Prolactinomas are typically benign but represent a major cause of endocrine dysfunction. However, their molecular subtypes remain undefined, and clinical implications of such subtypes are unclear. The objective of this study was to characterize the genomic subtypes of prolactinomas and evaluate associated clinicopathological and immunological features. - Source: PubMed
Publication date: 2026/06/26
Wang Da PengLiu Yan TingDai Yu TingChen De ShengCheng Yi JunLin Shao JianZhang YanXue LiXie JingWu Zhe Bao - Osteoarthritis (OA) causes chronic pain and impaired mobility in dogs. Since current therapies cannot restore damaged articular cartilage, tissue engineering approaches offer promising therapeutic strategies. This study aimed to investigate whether peri-ovarian adipose tissue (POAT) represents a biologically competent and functionally relevant alternative source of mesenchymal stromal cells (MSCs) compared to subcutaneous adipose tissue (SAT). Samples were collected from five healthy and normal-weight Labrador Retrievers undergoing routine ovariectomy. MSCs were characterized according to the International Society for Cellular Therapy, including doubling time, growth curves, colony-forming unit assays, immunophenotyping, and trilineage differentiation potential. Chondrogenic differentiation was assessed through Alcian Blue staining and qPCR analysis of , , , and expression at multiple timepoints. MSCs derived from both adipose depots showed comparable mesenchymal characteristics, proliferative capacity, immunophenotypic profiles, and multilineage differentiation potential. POAT-MSCs exhibited enhanced chondrogenic differentiation compared to SAT-MSCs, with stronger extracellular matrix deposition and significantly increased expression at later stages of differentiation than SAT-MSCs. expression supported a more advanced chondrogenic commitment in POAT-derived cells, while expression remained low and stable in both groups. These preliminary findings suggest that POAT, routinely discarded after ovariectomy, may represent a promising and ethically advantageous source of canine MSCs for regenerative medicine. - Source: PubMed
Publication date: 2026/06/19
Sergio MirkoMirra GiorgioGiorgino RiccardoLange-Consiglio AnnaMartini ValeriaModina Silvia ClotildeCarnevale LilianaVeronesi Maria CristinaBazzocchi ChiaraPocar PaolaStocchero ChiaraCanciani BarbaraHerrera Millar Valentina RafaelaDi Giancamillo Alessia - Mesenchymal progenitor cells (MPCs) play a significant role in articular cartilage homeostasis and regeneration. Yet, the functional dynamics and molecular characteristics of MPCs may differ significantly across various pathological conditions. Hence, this study comprehensively investigates the biological and molecular characteristics of MPCs isolated from articular cartilage of patients with osteoarthritis (OA) and rheumatoid arthritis (RA), aiming to uncover disease-specific differences that could offer insights into targeted regenerative therapies. Using flow cytometry, gene expression analysis, and in vitro differentiation assays, we assessed the phenotype, growth potential, senescence, cytogenetic instability, and chondrogenic potential to delineate molecular pathways uniquely active in each disease context. Phenotypically, both OA and RA-MPCs retained markers of mesenchymal stem cells (MSCs), but OA-derived MPCs exhibited higher fold expression of progenitor markers (, , , and ), suggesting a more activated state. Functionally, OA-MPCs demonstrated increased growth kinetics (higher proliferation rate and decreased population doubling time) with a significant shift towards adipogenic lineages (increased fold expression of , , and ). However, there were no differences in the osteogenic and chondrogenic potential. Gene expression analysis revealed upregulation of genes involved in extracellular matrix production and cartilage development (, , , , , , , , and ) in 3D cultures compared with 2D or monolayer cultures. Collectively, these findings demonstrate that, while multipotent MPCs are present in both OA and RA articular cartilage, they can exhibit fundamentally altered biological behaviors and molecular signatures reflective of the local disease microenvironment. Understanding these differences is critical for optimizing cell-based therapeutic strategies tailored to each condition and may facilitate the development of novel interventions targeting endogenous progenitor cells for cartilage repair. - Source: PubMed
Publication date: 2026/06/10
Manjappa Akshay BairapuraNitilapura NarendraShetty SiddharthRao ShamaBabu SanthoshShetty JayaprakashaShetty ReshmaBasavarajappa Mohana Kumar