SOX9
- Known as:
- SOX9
- Catalog number:
- GT15207-100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SOX9
Related genes to: SOX9
- Gene:
- SOX9 NIH gene
- Name:
- SRY-box 9
- Previous symbol:
- CMD1, CMPD1
- Synonyms:
- SRA1
- Chromosome:
- 17q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-25
- Date modifiied:
- 2018-06-25
Related products to: SOX9
Related articles to: SOX9
- Precise mitochondrial targeting in chondrocytes is essential for interrupting the vicious cycle of oxidative stress and cartilage degeneration in osteoarthritis (OA). Here, we develop a biomimetic nanoplatform (CM@SS31-Se) with dual targeting capability. This system comprises selenium nanoparticles with glutathione peroxidase mimetic activity as the antioxidant core, SS31 peptide for mitochondrial homing, and chondrocyte membrane coating for homotypic recognition. Following intra-articular injection, the nanoplatform demonstrates prolonged joint retention up to 14 days with favorable biocompatibility. Functionally, the outer membrane shell facilitates chondrocyte internalization through homotypic recognition, the SS31 peptide promotes mitochondrial accumulation through its cardiolipin binding affinity, and the selenium core subsequently provides sustained mtROS scavenging. These dual-targeting properties restore mitochondrial membrane potential and ATP synthesis, upregulate anabolic markers (SOX9, Col II, Aggrecan), and downregulate MMP13 and pro-inflammatory mediators, ultimately promoting the restoration of a regenerative phenotype in degenerative chondrocytes. Thus, this biomimetic nanoplatform enables guided mitochondrial functional restoration, demonstrating therapeutic potential for attenuating OA progression. - Source: PubMed
Publication date: 2026/08/12
Zhang ZihanDu QianZhu ZiyinZhu ZhitongHe JialinXin ZhijunDeng Jiang - Although the zebrafish (Danio rerio) is widely used as a model for gastrointestinal research, a comprehensive, multi-modal characterization of the adult posterior intestine has not previously been reported. In this study, we present the first integrated histological, ultrastructural, and immunofluorescent atlas of the adult zebrafish posterior intestine, together with normative morphometric reference data for distinct intestinal cell populations. Notably, we identify, for the first time, vimentin-positive cup cells exhibiting ultrastructural characteristics consistent with mammalian M cells. We also provide the first evidence of telocytes within the zebrafish posterior intestinal wall, distinguished by their moniliform telopodes and fibronectin immunoreactivity. Furthermore, the unexpected localization of fibronectin within the enterocyte cytoplasm suggests a previously unrecognized role in epithelial barrier organization and maintenance. The detection of SOX9 immunoreactivity in basally positioned epithelial cells is consistent with the presence of a putative progenitor cell population that warrants further functional investigation. Together, these findings establish a comprehensive morphological and morphometric reference framework for the adult zebrafish posterior intestine, providing a valuable foundation for studies of vertebrate intestinal biology, epithelial homeostasis, mucosal immunity, and comparative gastrointestinal research. - Source: PubMed
Mohamedien DaliaHussein Marwa MMokhtar Doaa MKikuchi YutakaHayashi ToshinoriAwad Mahmoud - Gyrification of the cerebral cortex is essential for healthy brain development, and disruptions to this process lead to severe structural and functional abnormalities associated with long-term behavioural and psychiatric consequences. Basal radial glial cells (bRGC), residing in the expanded outer subventricular zone (oSVZ), are thought to drive gyrification. However, the transcriptional programs guiding this process remain poorly defined. We aimed to profile gene expression within the oSVZ of the developing ferret cortex, a species that displays postnatal gyrification, at two key stages of cortical folding, capturing its onset and progression. Discrete regions of the oSVZ were microdissected beneath the coronal gyrus and suprasylvian sulcus at the onset (P5, n = 5) and middle (P15, n = 5) of gyrification in the ferret. We performed RNA sequencing, differential expression analysis with gene ontology and pathway analyses with RT-qPCR validation of candidate genes. The results revealed spatially enriched gene sets associated with progenitor proliferation, self-renewal, and neurogenesis, as well as temporal transcriptional enrichment for axonogenesis and extracellular matrix regulation. RT-qPCR validated spatial and temporal expression differences, confirming consistent trends among some key folding-associated candidate genes. However, some genes (namely SOX9, AJAP1, and SEMA3D) showed inverse expression patterns compared to those detected by RNA-Seq and could not be considered validated. Together, these data define the molecular architecture of gyrification, providing a comprehensive transcriptional atlas of the oSVZ in the developing brain. Our findings advance understanding of how coordinated gene networks shape cortical folding, offering insights into the evolutional expansion of the mammalian brain. - Source: PubMed
Publication date: 2026/08/12
Barresi MikaelaJohnstone AliceQuezada SebastianQuigley AnitaTolcos Mary - Craniosynostosis is a congenital disorder characterized by premature fusion of cranial sutures. Lambdoid synostosis is a rare and severe form of the disease, but its developmental etiology remains poorly understood. Although ectopic cartilage has been associated with lambdoid suture fusion, whether abnormal chondrocyte development is causative has not been directly tested. Here, we investigated the role of platelet-derived growth factor receptor alpha (PDGFRα) signaling in chondrocyte development and lambdoid suture morphogenesis. Mesoderm-specific expression of an autoactivated Pdgfra allele (Pdgfra+/K) caused premature fusion of the lambdoid and occipitointerparietal sutures, preceded by excessive cartilage expansion during embryogenesis. Spatial transcriptomic analysis identified a PDGFRα-dependent transcriptional program characterized by increased Col2a1, Sox9, and Sfrp2 expression, indicating maintenance of chondrocytes in a proliferative progenitor state. Consistently, PDGFRα-activated chondrocytes exhibited increased proliferation. Moreover, expression of Pdgfra+/K in the Col2a1Cre lineage selectively induced occipitointerparietal suture fusion. Together, these findings demonstrate that PDGFRα signaling promotes proliferative cartilage and impairs chondrocyte maturation, identifying dysregulated chondrogenesis as a developmental mechanism underlying lambdoid craniosynostosis. - Source: PubMed
Publication date: 2026/08/12
Bartoletti GarrettEbright RyanLiang HaoyangJaramillo JosueSammarco MimiXu XiaojiangHe Fenglei - Meniscal injury is a leading cause of early-onset osteoarthritis, yet regenerative options remain limited. This study investigates a nonwoven polyethylene terephthalate (PET) scaffold for meniscus tissue engineering and assesses its capacity to support mesenchymal stromal cell (MSC) proliferation and chondrogenic differentiation under dynamic loading. Human MSCs are seeded onto PET scaffolds (400-420 g/m, 85% porosity) and cultured for up to 21 days under basal medium (Ctr), chondrogenic differentiation conditions (ChD), or ChD combined with dynamic loading (ChD + Dyn, 12% strain, 1 Hz, 1 h/day, 5 days/week). PET scaffolds support uniform MSC adhesion and colonization. Compared with ChD alone, ChD+Dyn significantly increases cell proliferation and transiently upregulated chondrogenic markers (SOX9, ACAN, COL1A1, COL2A1) while suppressing the hypertrophic marker COL10A1. Although collagen deposition and construct biomechanics remained unchanged over 21 days, glycosaminoglycan accumulation was reduced in the ChD + Dyn group compared with ChD. RNA sequencing revealed distinct mechanosensitive transcriptional signatures induced by dynamic loading, particularly in genes associated with extracellular matrix remodeling, mechanotransduction, and developmental signaling pathways. These findings demonstrate that nonwoven PET provides a mechanically robust scaffold for meniscus tissue engineering and that dynamic loading promotes MSC proliferation while transiently regulating chondrogenic differentiation and mechanoadaptive matrix remodeling toward a meniscus-like phenotype. - Source: PubMed
Publication date: 2026/08/11
Teixeira Graciosa Quelhasde Roy LuisaFeldmeier Anna-LottaAhmad MubashirPilão SofiaAhrens MariaIgnatius AnitaLinti CarstenSeitz Andreas Martin