CD178 _ Fas Ligand
- Known as:
- CD178 _ Fas Ligand
- Catalog number:
- FASL12-S
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD178 _ Fas Ligand
Related genes to: CD178 _ Fas Ligand
- Gene:
- FASLG NIH gene
- Name:
- Fas ligand
- Previous symbol:
- APT1LG1, TNFSF6
- Synonyms:
- FasL, CD178
- Chromosome:
- 1q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-09
- Date modifiied:
- 2019-04-23
Related products to: CD178 _ Fas Ligand
&_945;2&_946;1 Integrin Ligand Peptide(1R,2R)_(+)_1,2_Diaminocyclohexane_N, min. 94%rost ligand (na(1S,2S)_(+)_1,2_Cyclohexanediamino_N, (S,S)_Jacobsen ligand(1S,2S)_(_)_1,2_Diaminocyclohexane_N,N min. 94% rost ligand (n(1S,2S)_(_)_1,2_Diaminocyclohexane_N,N Rost ligand24(S)-Hydroxycholesterol Ligand24(S)-Hydroxycholesterol Ligand24(S)-Hydroxycholesterol, LXR ligand, (3β,24S)-Cholest-5-ene-3,24-diol, CAS: 474-73-724(S)-Hydroxycholesterol, LXR ligand, (3β,24S)-Cholest-5-ene-3,24-diol, CAS: 474-73-72B4,CD244,h2B4,Homo sapiens,Human,NAIL,Natural killer cell receptor 2B4,NK cell activation-inducing ligand,NK cell type I receptor protein 2B4,NKR2B42C101 Fas Ligand2R2 Fas3.22 Fas- FITC labeled3.22 Fas-PE labeled3D5 Fas Death Domain Related articles to: CD178 _ Fas Ligand
- This study characterizes the acute exercise-induced remodeling of the whole-blood transcriptome and inferred immune microenvironment in pediatric and adolescent patients with sickle cell anemia (SCA). By integrating transcriptomic profiling (GEO: GSE244401) with immune cell deconvolution and multi-level regulatory network analyses, we systematically dissected the molecular response to an acute interval exercise challenge. We identified 107 differentially expressed genes (89 upregulated, 18 downregulated) primarily enriched in natural killer (NK) cell cytotoxicity, T cell activation, and antigen presentation pathways. Protein-protein interaction (PPI) network analysis highlighted 16 hub genes (e.g., , , ), whose upregulation significantly correlated with an increased inferred abundance of circulating NK cells and CD8 + T cells, alongside a concomitant reduction in neutrophils and eosinophils. Furthermore, regulatory network analysis implicated master transcription factors (e.g., EZH2, GLIS2) and key miRNAs (e.g., miR-21-5p, miR-130b-3p) in coordinating these acute cytotoxic responses through target genes such as and . In conclusion, acute exercise triggers a rapid remodeling of the immune landscape, potentially attenuating granulocyte-driven inflammation while activating lymphocyte-mediated immunity. These findings reveal the complex "double-edged" transcriptional responses to exercise in pediatric SCA, providing a critical mechanistic foundation for developing individualized, safely monitored exercise prescriptions. - Source: PubMed
Publication date: 2026/06/28
Zhao JiajiaShang HaonanFu ZetingLi HongliTian LihengLi Chunpeng - LARC patients exhibit heterogeneity in their response to total neoadjuvant therapy (TNT). This study aims to screen and identify plasma biomarkers associated with treatment response to TNT in patients with locally advanced rectal cancer (LARC) to predict pathological complete response (pCR). - Source: PubMed
Publication date: 2026/06/08
Zhu ZonglinWen KaizhenZou BaoyiKang YanhuaChen JingqingZhu BinFan LipingHuang Haobo - The immune system is a major driver in pancreatic cancer development. Several prospective cohort studies have found associations for single immune system-derived proteins such as IL6 or CRP, but results are inconclusive, and Omics-based research is scarce. Hence, we aimed to investigate associations of a comprehensive protein panel with the risk of pancreatic cancer. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 92 immune proteins were measured in baseline blood samples of 406 incident pancreatic cancer cases and 406 sex- and age-matched controls, using the Olink Immuno-Oncology panel. Multivariable adjusted conditional logistic regression was used to estimate odds ratios (OR, 95% CI) for protein levels in association with pancreatic cancer risk. Eight biomarkers were associated with pancreatic cancer risk (MMP12, LAMP3, CD28, IL-6, IL-12, FASLG, PD-L2, and PDCD1) but only MMP12 was significantly associated after multivariable adjustments for confounders and the seven proteins, with OR = 1.56 (95% CI: 1.20-2.03) for a doubling in protein concentration. After correction for multiple testing, none of the proteins were associated with risk. Restricting analyses to cases diagnosed within the first 4 years and 4-8 years after recruitment resulted in OR of 1.89 (95% CI: 1.28-2.80) and 1.37 (95% CI: 1.01-1.86) for MMP12, respectively. Higher levels of MMP12 were associated with pancreatic cancer risk specifically in those diagnosed shortly after recruitment, while other immune-related factors were not associated with risk. Further cohort studies are needed to confirm our initial findings. - Source: PubMed
Publication date: 2026/06/23
Katzke Verena AChen YueDutta SrimantiCanzian FedericoAndersen Julie Louise MunkRostgaard-Hansen Agnetha LinnBouteille LéaRebours VincianeTruong ThérèseSchulze Matthias BBendinelli BenedettaPala ValeriaSimeon VittorioTumino RosarioSacerdote CarlottaVermeulen RoelKolijn P MartijnElias Sjoerd GCrous-Bou MartaSánchez Maria-JoséJimenez-Zabala AnaHuerta José MaríaGuevara MarcelaWareham NickBreeur MarieJohansson MattiasYarmolinsky JamesCampa DanieleKaaks Rudolf - The worldwide climate is thought to be drastically changing as a result of the global temperatures, a phenomenon known as "global warming". Thermal stress is a crucial obstacle facing buffalo cyclicity. Investigation of the molecular regulation concerning proliferation and apoptosis of corpus luteum (CL) is not fully comprehended in buffaloes. We aimed to (1) study mRNA expression of candidate genes related to proliferation (PGR, AGTR1, and LHCGR) and apoptosis (TNF, BAX, FASLG, CASP3, AGTR2 and PTGS2), (2) explore effect of thermal stress on the expression of HSP70, NOS1, NOS2 mRNAs, NO and SOD concentrations in CL homogenate during different stages of CL. For this, ovaries (n = 70) were collected in pairs from buffaloes during cold and hot seasons. According to morphology of CL, samples were divided into: early, mid, and late. For RNA isolation, NO and SOD concentrations, small sections from CL stages were frozen in - 80 °C. The results showed that PGR, AGTR2, TNF, BAX, cALP2beta and PTGS2 mRNAs decreased (P < 0.001) at different stages of CL at hot season. The decline of AGTR2 associated with decreased NOS2 mRNA, which consequently affected TNF, BAX, and CASP3 mRNAs. Apoptosis might be affected by direct effect of AGTR2 on CASP3 during thermal stress. We supposed that NO had a regulatory role during early and late stages of CL. It could be concluded that thermal stress (THI > 68) changed the expression of proliferation and apoptosis genes of CL in Egyptian buffaloes. Finally, the thermal stress in cold or hot seasons has marked impact on CL dynamics. - Source: PubMed
Publication date: 2026/06/22
Galal Samaa MIbrahim SallyMahmoud KarimaAdel OlaShokry Aya AEl-Belely M SIsmail S T - The OSCs population in postnatal chickens is a potential reservoir for follicular renewal, however, the signals that regulate OSC maintenance and expansion are not well understood. Here, we identify anti-Müllerian hormone (AMH) as a key mitogen for chicken OSCs and define its signaling mechanism. Following the successful isolation and characterization of OSCs from adult hens, we found that these cells exhibit a distinctive hormonal receptor profile: they highly express the AMH type II receptor (AMHR2) while showing negligible expression of canonical gonadotropin receptors (FSHR, LHR) and estrogen receptors (ESR1, ESR2). Functionally, AMH robustly stimulated OSCs proliferation in both culture and ex vivo ovarian explants. Transcriptomic analysis revealed that AMH treatment alters the expression of 305 genes, coordinating the activation of major pro-proliferative pathways-including ErbB, mTOR, and Wnt signaling-and concurrently suppressing apoptotic and necroptotic pathways. This effect is mediated through phosphorylation of Smad1/5/8 without affecting their mRNA or total protein levels. Critically, pharmacological inhibition of Smad1/5/8 phosphorylation completely blocked AMH-induced proliferation and reversed the AMH-driven upregulation of proliferative genes (MYC, EGR4, CDK1, BLK) as well as the downregulation of the pro-apoptotic gene FASLG. Our results establish a novel, pro-proliferative role for AMH in avian ovarian biology, operating through a conserved AMH expand the OSCs pool by dual regulation of cell cycle and survival pathways. This work reframes AMH's physiological role beyond its classical function in follicle recruitment and offers new insights into the hormonal control of OSCs, with implications for enhancing reproductive longevity in poultry. - Source: PubMed
Publication date: 2026/05/20
Sun QingYu ChanghaoSun HongcaiHao JinguiLi ZhenyaMa YuxiaoWang JinZhu Guiyu