Alkaline phosphatase _ ALPL
- Known as:
- Alkaline phosphatase _ ALPL
- Catalog number:
- NB600-540
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Alkaline phosphatase _ ALPL
Related genes to: Alkaline phosphatase _ ALPL
- Gene:
- ALPL NIH gene
- Name:
- alkaline phosphatase, biomineralization associated
- Previous symbol:
- HOPS
- Synonyms:
- TNSALP, TNALP, TNAP
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-08-08
Related products to: Alkaline phosphatase _ ALPL
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodies Alkaline Phosphatase Conjugated Affinity Purified anti_Swine IgG (H&L) [Goat]1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 900 slides plus (large size1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 350 pl1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 900 plu105 kDa islet cell antigen,BEM-3,Brain-enriched membrane-associated protein tyrosine phosphatase,ICA105,PTP IA-2,PTPLP,Ptprn,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase-like N,R-P12 Lipoxygenase antibody (Alkaline Phosphatase)12 Lipoxygenase antibody (Alkaline Phosphatase)130 kDa myosin-binding subunit of smooth muscle myosin phophatase,Chicken,Gallus gallus,MBS,Myosin phosphatase target subunit 1,Myosin phosphatase-targeting subunit 1,MYPT1,PP1M subunit M110,PPP1R12A,14 kDa phosphohistidine phosphatase,Bos taurus,Bovine,Phosphohistidine phosphatase 1,PHP14,PHPT114 kDa phosphohistidine phosphatase,CGI-202,Homo sapiens,HSPC141,Human,Phosphohistidine phosphatase 1,PHP14,PHPT1,Protein janus-A homolog14 kDa phosphohistidine phosphatase,Mouse,Mus musculus,Phosphohistidine phosphatase 1,Php14,Phpt114 kDa phosphohistidine phosphatase,Oryctolagus cuniculus,Phosphohistidine phosphatase 1,PHP,PHP14,PHPT1,Protein histidine phosphatase,Rabbit14 kDa phosphohistidine phosphatase,Phosphohistidine phosphatase 1,PHP14,PHPT1,Pig,Sus scrofa Related articles to: Alkaline phosphatase _ ALPL
- Coronary artery calcification (CAC) is a pressing issue in cardiology. Mesenchymal stem cells (MSCs) derived from epicardial adipose tissue (EAT) may serve as a source of osteoblasts in the cardiovascular system. This study aimed to evaluate and compare the immunophenotype, proliferation, and osteogenic potential of EAT-MSCs from patients with coronary artery disease (CAD) and those with aortic stenosis (AS). The immunophenotype of MSCs was analyzed based on key markers: CD105, CD90, CD73, CD31, CD34, CD45, HLA-DR. Cell proliferation was assessed by the doubling time of the population and the specific growth rate of the cultures. The osteogenic potential was evaluated by the expression levels of the , , , and genes using PCR, as well as the protein levels in supernatants via ELISA. Qualitative detection of osteogenic proteins in cells by immunofluorescence staining. The intensity of extracellular matrix mineralization was measured using photometric methods. CD73 expression in EAT-MSCs from CAD patients was nearly 50% lower than in EAT-MSC cultures from AS patients. Following osteogenic induction, EAT-MSCs from CAD patients showed increased expression of osteogenic marker genes and their corresponding proteins. The intensity of extracellular matrix mineralization by osteoblasts derived from EAT-MSCs of CAD patients was higher than in the comparison group. EAT-MSCs from CAD patients with coronary calcification demonstrated reduced CD73 expression in culture and enhanced osteogenic potential compared to patients without coronary artery involvement. - Source: PubMed
Publication date: 2026/07/15
Gruzdeva Olga VSlesareva Tamara AGorbatovskaya Evgeniya EDolmatova Sofia EDyleva Yulia AFanaskova Elena VKokov Alexander NNishonov Asliddin BBarbarash Olga L - Jinfeng pills (JFP), a well-known traditional Chinese medicine (TCM) consisted of 9 herbs, benefit Qi, nourish the blood, effectively regulate the menstrual cycle, promote ovulation and improve endometrial thickness and blood flow. Previous studies have shown that JFP has certain effect on premature ovarian insufficiency (POI). In this prospective cohort study, the effect and mechanisms of JFP on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in poor ovarian response(POR) was investigated. - Source: PubMed
Publication date: 2026/07/18
Kong XumeiLuo QianwenHuang TianhongChen FuruiZhang YananXiong DongshengQiu YuLai WeiYan XiaoyanLong FangyiGong Yan - Alkaline phosphatase (ALP) plays an essential role in skeletal mineralization and bone metabolism. While elevated ALP levels are commonly investigated in clinical practice, persistently low ALP values are often overlooked despite their potential association with hypophosphatasia (HPP), a rare metabolic bone disorder caused by pathogenic variants in the ALPL gene. This study aimed to determine the prevalence and clinical characteristics of adults with persistently low ALP in a large tertiary care hospital. - Source: PubMed
Publication date: 2026/07/18
Alshahrani FahadAlsuliman SaraAlkalefah ReemaAlmutairi ShadenAleidi YaraAlmohaya Mohammed - Skeletal aging involves pyrophosphate/phosphate disequilibrium and impaired mechanotransduction, which together constrain osteogenic repair. We develop OsteoVes, a matrix-vesicle-mimetic extracellular organelle that combines tissue-nonspecific alkaline phosphatase (ALP)-mediated inorganic pyrophosphate (PPi) hydrolysis, nano-hydroxyapatite nucleation, and a mesenchymal stem cell-derived membrane interface for extracellular matrix anchoring. In aged human mesenchymal stem/stromal cells (MSCs), OsteoVes restores the Pi/PPi set point, suppresses PPARG activity, promotes RUNX2 nuclear translocation, and supports osteogenic differentiation. OsteoVes also increases actomyosin tension and engages an ITG/FAK-PIEZO1-JNK/c-JUN-RUNX2 mechanotransduction-associated pathway. In elderly osteopenic/osteoporotic patient-derived MSCs, OsteoVes supports ALP activity and matrix mineralization. Systemic administration improves trabecular microarchitecture and mechanical properties in naturally aged mice within 4 weeks, remains active in Alpl progeroid mice, and elicits osteoanabolic serum and imaging responses without evident short-term toxicity in metabolically aged rhesus macaques. These findings identify matrix vesicle (MV) dysfunction as an extracellular osteometabolic control point for short-term chemo-mechanical rescue. - Source: PubMed
Publication date: 2026/07/16
Zhang LiqiangWei XiaoZhang KeDing FanGuo ZiliangZou BinHe WangxiaoLiu Wenjia - Aging is among the major risk factors for male infertility. Coridius chinensis is a traditional Chinese insect medicine that has been utilized to improve male reproduction in China for hundreds of years, but elucidation of the underlying mechanisms involved remains challenging. - Source: PubMed
Publication date: 2026/07/08
Zhang MeiZeng FengyinLou HuixianMa JingHou Xiaohui