GRB2 _ ASH (N_term)
- Known as:
- GRB2 _ ASH (N_term)
- Catalog number:
- NB110-57014
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GRB2 _ ASH (N_term)
Related genes to: GRB2 _ ASH (N_term)
- Gene:
- GRB2 NIH gene
- Name:
- growth factor receptor bound protein 2
- Previous symbol:
- -
- Synonyms:
- NCKAP2
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-03-04
- Date modifiied:
- 2016-10-05
Related products to: GRB2 _ ASH (N_term)
Related articles to: GRB2 _ ASH (N_term)
- Atherosclerosis is a major cause of ischemic stroke and is characterized by complex immune-metabolic dysregulation. VAV3, a Rho guanine nucleotide exchange factor, regulates multiple cellular processes, but its role in vascular pathology remains unclear. This study aimed to explore the function and mechanism of VAV3 in atherosclerosis. - Source: PubMed
Publication date: 2026/06/04
Wang GuorongPu ChenLi QingLiu QiangWan XiaobinDeng JunDai MinXie BinHuang LianghuiZhao YanPing - Dynamic protein complex assembly is critical for regulating various biological processes. Proximity labeling (PL), best represented by the ascorbate peroxidase APEX2, allows these molecular events to be captured in living cells in a spatiotemporal manner. However, the hydrogen peroxide (HO) dependence of APEX2 has hindered its application in sensitive living systems. Here we introduce ROProx, a radical- and oxygen-driven photoreactive PL technology that leverages the chemically evolved biotin-naphthylamine probe BN2, which has strong binding affinity for APEX2, and the unexpected tyrosyl radicals in APEX2. ROProx labels dynamic cytosolic protein complexes in living cells within seconds, with a range of 10 nm, and is precisely controlled by mild blue light irradiation without HO. Additionally, we apply ROProx to explore the phosphotyrosine-dependent GRB2 interactome in living mice by simply injecting BN2 for 5 minutes. ROProx should, therefore, open broad opportunities for PL chemical evolution and applications in other living systems. - Source: PubMed
Publication date: 2026/05/28
Ke MiLiang FuchaoWang GuangqinHe AnMa BaixuLiu ZheyiWang JieXu YanLi YanliDong ZheZhong ZhihuaTang ZhiyaoSun PengyuHe KangminWang FangjunLiu ZhiyongYang XuemingTao LizhiTian Ruijun - - Source: PubMed
Publication date: 2026/05/28
Wittayavimol NattamolphanIwabuchi ErinaSasano HironobuSwart Amanda CBoonyaratanakornkit Viroj - Thymocyte selection is essential for establishing the T cell repertoire, maintaining self-tolerance and preventing autoimmunity. Themis, the archetypal member of a metazoan protein family defined by CABIT domains, centrally regulates this process by integrating T cell receptor (TCR) signalling. Themis has been proposed to constitutively partner with the multifunctional adaptor Grb2, yet the structural and mechanistic basis of this assembly has remained enigmatic. Here, we use Cryo-EM to reveal how the tandem CABIT domains and proline-rich sequence of Themis cooperatively engulf the C-terminal SH3 domain of Grb2, while the unbound domains of Grb2 remain poised to recruit additional binding partners. Furthermore, we uncover inherent interdomain flexibility in unbound Themis that resolves upon Grb2 binding. Structure-guided mutations abrogate the Themis-Grb2 interaction and fail to regulate the tyrosine phosphatase SHP-1 after TCR stimulation, recapitulating the phenotype of Themis-deficient cells. Our findings define the Themis-Grb2 complex as a dynamic structural hub in T cell signalling. - Source: PubMed
Publication date: 2026/05/20
Clancy Danielle MSanz-Sanjuan AlbaGilis ElisabethTougaard PeterVelghe ImkeVan Droogenbroeck YanaFelix JanBloch YehudiCuadrado Álvaro FuronesMerceron RomainSchenck StephanVandenabeele PeterBrunner Janine DTaghon TomElewaut DirkSavvides Savvas N - Sorafenib resistance remains a major therapeutic challenge in advanced hepatocellular carcinoma (HCC). This study aimed to investigate the role of growth factor receptor-bound protein 2 (GRB2) in sorafenib resistance of HCC cells under hypoxic conditions and to elucidate the underlying molecular mechanisms involving the PI3K/AKT signaling pathway. - Source: PubMed
Publication date: 2026/05/06
He JiaqianKong YinzhiWang YunyongFang QiaolingWu HemengDu KeweiLuo YuzhenTan JinnaYin HuiLin HongshengLi Mingfen