Alkaline phosphatase _ ALPL
- Known as:
- Alkaline phosphatase _ ALPL
- Catalog number:
- NB100-62324
- Product Quantity:
- 0.2 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Alkaline phosphatase _ ALPL
Related genes to: Alkaline phosphatase _ ALPL
- Gene:
- ALPL NIH gene
- Name:
- alkaline phosphatase, biomineralization associated
- Previous symbol:
- HOPS
- Synonyms:
- TNSALP, TNALP, TNAP
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-08-08
Related products to: Alkaline phosphatase _ ALPL
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- Skeletal aging involves pyrophosphate/phosphate disequilibrium and impaired mechanotransduction, which together constrain osteogenic repair. We develop OsteoVes, a matrix-vesicle-mimetic extracellular organelle that combines tissue-nonspecific alkaline phosphatase (ALP)-mediated inorganic pyrophosphate (PPi) hydrolysis, nano-hydroxyapatite nucleation, and a mesenchymal stem cell-derived membrane interface for extracellular matrix anchoring. In aged human mesenchymal stem/stromal cells (MSCs), OsteoVes restores the Pi/PPi set point, suppresses PPARG activity, promotes RUNX2 nuclear translocation, and supports osteogenic differentiation. OsteoVes also increases actomyosin tension and engages an ITG/FAK-PIEZO1-JNK/c-JUN-RUNX2 mechanotransduction-associated pathway. In elderly osteopenic/osteoporotic patient-derived MSCs, OsteoVes supports ALP activity and matrix mineralization. Systemic administration improves trabecular microarchitecture and mechanical properties in naturally aged mice within 4 weeks, remains active in Alpl progeroid mice, and elicits osteoanabolic serum and imaging responses without evident short-term toxicity in metabolically aged rhesus macaques. These findings identify matrix vesicle (MV) dysfunction as an extracellular osteometabolic control point for short-term chemo-mechanical rescue. - Source: PubMed
Publication date: 2026/07/16
Zhang LiqiangWei XiaoZhang KeDing FanGuo ZiliangZou BinHe WangxiaoLiu Wenjia - Aging is among the major risk factors for male infertility. Coridius chinensis is a traditional Chinese insect medicine that has been utilized to improve male reproduction in China for hundreds of years, but elucidation of the underlying mechanisms involved remains challenging. - Source: PubMed
Publication date: 2026/07/08
Zhang MeiZeng FengyinLou HuixianMa JingHou Xiaohui - Hypophosphatasia (HPP) is a rare metabolic disorder caused by loss-of-function ALPL variants and characterized by heterogeneous skeletal and extra-skeletal manifestations. Although recent diagnostic criteria include ALPL variants, the diagnosis can be made based solely on clinical features. In adult-onset HPP, however, symptoms are often mild or nonspecific, including musculoskeletal symptoms and fatigue, making it difficult to differentiate from other conditions. This retrospective, cross-sectional study aimed to integrate genetic and biochemical data to enhance the clinical interpretation of low alkaline phosphatase (ALP) in patients with bone disorders. Among 865 consecutive adults visiting a bone-specialized outpatient department, patients with persistent hypophosphatasemia underwent ALPL sequencing. Clinical and biochemical characteristics were compared among three groups: biallelic or monoallelic variants with dominant-negative effect (DNE), monoallelic variants without DNE, and variant-negative individuals. Fifty-six patients (6.5%) showed persistent hypophosphatasemia. Two (0.2%) were compound heterozygotes, and 29 (3.4%) carried monoallelic variants without DNE. Clinical symptoms and secondary causes of hypophosphatasemia were similar between monoallelic without DNE and variant-negative patients, whereas serum ALP, urinary phosphoethanolamine (PEA), and plasma inorganic pyrophosphate (PPi) differed significantly. A model using thresholds of ALP < 35 IU/L, urinary PEA > 91 µmol/gCr, and plasma PPi > 1.96 µmol/L demonstrated high diagnostic performance for identifying patients with monoallelic variants without DNE. This study elucidated the complex clinical spectrum of patients with low ALP. Although clinical manifestations were comparable between monoallelic individuals without DNE and variant-negative individuals, distinct biochemical profiles were observed. Integrating genetic nosology into current diagnostic criteria may refine clinical decision-making. - Source: PubMed
Publication date: 2026/07/15
Hidaka NaokoKimura SoichiroWatanabe SoAkiyama TomoyukiTachikawa KanakoMichigami ToshimiAdachi NatsuhoIrie KokiHoshino YoshitomoKato HajimeNangaku MasaomiTanaka SakaeMakita NorikoSaito TakuIto Nobuaki - Calcium (Ca) and magnesium (Mg) ions enhance the osteoconductivity of titanium oral implants, yet their effects on clinically established complex topographies remain under-explored. This study evaluated the effects of Ca and Mg incorporation into sandblasted, large-grit-, acid-etched (SLA) surfaces on the osteogenic differentiation of human mesenchymal stem cells (MSCs). - Source: PubMed
Kim Jae-MinKim Young-KyungPark Jin-Woo - Hypophosphatasia (HPP) is a rare inherited metabolic bone disorder caused by pathogenic variants in the gene, with a wide clinical spectrum ranging from severe pediatric forms to mild adult-onset disease. In contrast, heterozygous variants in are a recognized cause of autosomal dominant short stature, often associated with advanced bone age and premature growth plate closure. We report a 16-yr-old girl evaluated for severe disproportionate short stature with growth arrest during early adolescence. Her medical history included benign childhood epilepsy, mild intellectual disability, and enamel abnormalities. Biochemical evaluation revealed persistently low serum and bone-specific alkaline phosphatase levels, while calcium-phosphate metabolism was otherwise normal. Genetic testing identified a heterozygous pathogenic variant (c.1426G>A; p.Glu476Lys), inherited from an asymptomatic father, consistent with autosomal dominant HPP with minimal clinical expression. Additionally, a maternally inherited variant of uncertain significance (c.511G>C; p.Ala171Pro) was detected. Based on phenotypic correlation and family segregation, the growth phenotype is more plausibly explained by -related growth plate dysfunction, while the variant likely represents an incidental or mildly expressed finding. This case highlights the importance of careful genotype-phenotype correlation and cautious interpretation of multiple genetic findings in the evaluation of severe short stature. - Source: PubMed
Publication date: 2026/02/15
Silva Joana AzevedoCosta Ana Rita AMazeda InêsMota CéuAbreu MariaBorges TeresaMendes Catarina