CKAP5
- Known as:
- CKAP5
- Catalog number:
- NBP1-06512
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CKAP5
Related genes to: CKAP5
- Gene:
- CKAP5 NIH gene
- Name:
- cytoskeleton associated protein 5
- Previous symbol:
- -
- Synonyms:
- ch-TOG, KIAA0097, TOG, TOGp
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-01
- Date modifiied:
- 2014-11-19
Related products to: CKAP5
Related articles to: CKAP5
- Artificial light at night (ALAN), intensified by coastal urbanization, is an emerging threat to coastal ecosystems. We used the rotifer Brachionus plicatilis and its prey Phaeocystis globosa as a model predator-prey system to examine rotifer life-history traits, predator-prey dynamics, and transcriptomic responses under varying ALAN intensities. ALAN altered maturation timing without affecting lifespan, and it reduced fecundity, population growth, and clearance rate, thereby delaying the depletion of P. globosa. Transcriptomic and network analyses showed that rotifers exposed to ALAN exhibited altered expression of candidate regulatory genes, including cytoskeleton-associated protein 5 (ckap5) and Raf proto-oncogene, serine/threonine kinase (raf) family members. These changes were associated with a CKAP5-associated microtubule module, RAF/PKA-related signaling, reproductive and cell-cycle-related pathways, and FoxO/autophagy-associated cellular-maintenance processes. These molecular responses provide potential regulatory clues for interpreting the phenotypic changes observed under ALAN exposure. Our findings help evaluate the potential effects of ALAN on zooplankton performance, and provide a scientific basis for assessing the environmental risks of coastal light pollution. - Source: PubMed
Yu QingqingXu TianyangShen YiruTao SiyingWang GongyuanLee Jae-SeongYang ZhouSun Yunfei - The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During this explosive period of cell biology, there was a parallel storyline involving clathrin which developed more slowly. It emerged that clathrin has an alternative function during mitosis, and that this function is unrelated to its membrane trafficking role. Clathrin forms part of a multiprotein complex that stabilizes microtubules of the mitotic spindle during the chromosome segregation events that occur during cell division. Due to this dual functionality, clathrin is sometimes referred to as a "moonlighting" protein. In this Perspective, we will take a look at this secret life of clathrin and examine how it carries out its mitotic function. - Source: PubMed
Royle Stephen J - It has become increasingly evident in recent years that nucleation of microtubules from a diverse set of microtubule organizing centers (MTOCs) requires both the γ-tubulin ring complex (γ-TuRC) and the microtubule polymerase XMAP215. Despite their essentiality, little is known about how these nucleation factors interact and work together to generate microtubules. Using biochemical domain analysis of XMAP215 and structural approaches, we find that the XMAP215 C-terminal region interacts broadly with γ-TuRC, involving a sixth TOG domain which binds γ-tubulin. Moreover, TOG6 is required for XMAP215 to promote nucleation from γ-TuRC to its full extent. Interestingly, we find that XMAP215 also depends strongly on TOG5 for microtubule lattice binding and nucleation. We further report a cryo-EM structure of TOG5 bound to the microtubule lattice that reveals promotion of lateral interactions between tubulin dimers. While XMAP215 constructs' effects on nucleation are generally proportional to their effects on polymerization, formation of a direct complex with γ-TuRC allows cooperative nucleation activity. Thus, we propose that XMAP215's C-terminal TOGs 5 and 6 play key roles in nucleation by promoting formation of longitudinal and lateral bonds in nascent γ-TuRC-templated microtubules at cellular MTOCs. - Source: PubMed
Publication date: 2026/05/09
McManus Collin TTravis Sophie MJeffrey Philip DZhang RuiPetry Sabine - The ovary is a central female reproductive organ responsible for producing oocytes and secreting steroid hormones. To investigate the molecular similarities and potential evolutionary origins of the ovary across vertebrates, we integrated publicly available single-cell and single-nucleus transcriptomic data from nine species, including oviparous animals (fish and chicken) and viviparous mammals (mouse, rat, sheep, goat, yak, monkey, and human). - Source: PubMed
Publication date: 2026/04/14
Xue BailingLiu YajingZhou ChenDossybayev KairatBaatar NarantuyaYudin NikolayZhang LinweiYang JiLi MenghuaXu Songsong - Prothrombin gene mutations can be associated with either a thrombotic or a bleeding risk. Genomic studies and coagulation workup can provide valuable information to better understand their clinical importance. - Source: PubMed
Publication date: 2026/02/02
Siegemund AnnelieSiegemund ThomasBönigk HagenSchlosser KristinaKonn KatjaKeil SabinePetros Sirak