NMUR2
- Known as:
- NMUR2
- Catalog number:
- NBP1-02351
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- NMUR2
Related genes to: NMUR2
- Gene:
- NMUR2 NIH gene
- Name:
- neuromedin U receptor 2
- Previous symbol:
- NMU2R
- Synonyms:
- -
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-24
- Date modifiied:
- 2014-11-19
Related products to: NMUR2
Related articles to: NMUR2
- Residual feed intake (RFI) is an indicator of feed efficiency that reflects variation in nutrient utilization independent of growth. This study characterized physiological traits and multi-omics profiles associated with divergent RFI in small-sized meat ducks. From an initial population of 500 1-day-old ducks, a total of 420 healthy ducks were individually housed from 21 to 42 d to record feed intake, and ducks with low RFI (LRFI) and high RFI (HRFI) were identified for further analyses. During the experiment, 30 ducks per group for growth performance, 15 ducks per group for plasma biochemical and 5 per group for multi-omics. Compared with HRFI ducks, LRFI ducks showed lower feed intake, lower feed conversion ratio (FCR), and lower plasma triglyceride concentrations, whereas body weight gain did not differ between groups. Shotgun metagenomic analysis showed that LRFI ducks were enriched in Bacteroides-related lineages and had higher predicted capacities for complex carbohydrate degradation, lipid and energy metabolism, and cofactor synthesis, whereas HRFI ducks were enriched in taxa including Subdoligranulum variabile and Clostridioides difficile. Untargeted cecal metabolomics revealed distinct lipid- and bile acid-related metabolic profiles between the 2 groups, including differences in long-chain lipid species and bile acid-associated metabolites. Hypothalamic transcriptomic analysis identified differentially expressed genes related to neuropeptide signaling, serotonin biosynthesis, intracellular signaling, and inflammatory regulation, including NMUR2, TPH1, and PTK2B. Correlation analysis integrating microbial taxa, metabolites, and hypothalamic transcripts further revealed coordinated associations among these features in small-sized meat ducks with divergent RFI. Overall, variation in feed efficiency in ducks was associated with differences in cecal microbiota, metabolite profiles, and hypothalamic gene expression, and these results highlight candidate microbial taxa, metabolites, and genes for further validation. - Source: PubMed
Publication date: 2026/06/17
Geng DandanDing YifanJiang YongWang ZhixiuChen GuohongChang GuobinBai Hao - The central neuromedin U receptor 2 (NMUR2) participates in regulating neuronal activity and synaptic transmission. This study aimed to explore the functional role of NMUR2 in climbing fiber-Purkinje cell synaptic transmission in mouse cerebellar slices. - Source: PubMed
Publication date: 2026/07/30
Li Mei-RuiPiao Ri-LongZhang Xu-DongWeng Wen-CaiChu Chun-PingQiu De-Lai - Neuromedin U (NMU) is a neuropeptide that was first identified in porcine spinal cord and exhibits diverse biological activities. It serves as an endogenous ligand for the human Neuromedin U receptor 2 (NMUR2), which is expressed exclusively in the hypothalamus. Because NMUR2 is involved in the regulation of appetite suppression and energy metabolism, it is considered a promising target for obesity treatment. CPN is a medium-sized peptide with selective agonistic activity against NMUR2. In this study, we evaluated the effect of peptide stability on brain delivery and the pharmacological effects after intranasal administration of two CPNs (CPN-116 and CPN-219) with different in vitro stabilities. The results of in vitro stability studies showed that both CPNs were more stable in the cerebrospinal fluid (CSF) than in the plasma and that the stability of CPN-219 in the serum, CSF, brain, and nasal cavity was better than that of CPN-116. For both CPNs, brain concentrations were higher in the nasal administration group than in the intraperitoneal administration group, and weight gain was also suppressed in the nasal administration group compared to the control group. Furthermore, both brain delivery and suppression of weight gain after nasal administration of CPN-219, which has good in vitro stability, were superior to those of CPN-116. It is evident that the stability of the peptide is an important factor for the direct delivery of peptides into the brain by intranasal administration. - Source: PubMed
Publication date: 2026/05/25
Tanaka AkikoYamashita AyariTakayama KentaroHayashi YoshioKatsumi HidemasaFurubayashi Tomoyuki - Neuromedin U (NMU), a neuropeptide, activates two types of NMU receptors (NMUR1 and NMUR2). The anti-obesity drug development focused on appetite suppression among physiological actions of NMU have been attempted worldwide; however, several reports have pointed out the possibility of tachyphylaxis induction by the repeated treatment of agonistic molecules, including our NMUR1 agonist CPN-267. Recently, NMUR1-mediated activation of type 2 inflammation has received considerable attention, although its tachyphylaxis induction has not yet been examined. In addition, through the acquisition of CPN-267, we were interested in the molecular functions affecting the in vitro efficacy (E) of mouse NMUR1. In this study, CPN-267-inspired derivatives of mouse NMU (mNMU) and palmitoylated analogs were designed and synthesized to reveal the structural factors modulating efficacy and evaluate the tachyphylaxis induction ability in mice. A calcium-mobilization assay using HEK293 cells transiently expressing receptors clarified that amino acid substitutions at positions 17-19 of mNMU to obtain NMUR1 selectivity led to a decrease in efficacy, and position 18 on palmitoylated analogs was the residue involving in the efficacy modulation. Using the most potent palmitoylated NMUR1 agonist 1, we confirmed that repeated subcutaneous injection for 3 consecutive days in mice rapidly induced tachyphylaxis of the appetite-suppressive effect. Moreover, we successfully demonstrated that the marked elevation in serum IL-5 levels by a single injection of peptide 1 was abolished by a similar repeated treatment, proposing that palmitoylated analogs acting on NMUR1 have the potential to develop as a suppressive agent against type 2 inflammation in future. - Source: PubMed
Publication date: 2026/05/12
Takayama KentaroMori KenjiNomura ErinaHanano MaiKuruma MomokoMorito KatsuyaTaguchi AkihiroTaniguchi AtsuhikoMiyazato MikiyaHayashi Yoshio - Neuromedin U (NMU) is an important neuropeptide. The paraventricular nucleus (PVN) is an important central nucleus for regulating the adipose afferent reflex (AAR). In this study, we aimed to investigate the acute effects of NMU in PVN on AAR, sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in the rats with obesity-related hypertension (OH) induced by a high-fat diet for 16 weeks. - Source: PubMed
Publication date: 2025/10/26
Wang QianZhu Han-XuGao QingXia Chen-XiCao Wen-JuanChen Ai-DongZhou Ye-BoChen Lei-Lei