SOX21 Lysate
- Known as:
- SOX21 Lysate
- Catalog number:
- NBL1-16349
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SOX21 Lysate
Related genes to: SOX21 Lysate
- Gene:
- SOX21 NIH gene
- Name:
- SRY-box 21
- Previous symbol:
- -
- Synonyms:
- SOX25
- Chromosome:
- 13q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-14
- Date modifiied:
- 2015-11-23
Related products to: SOX21 Lysate
Related articles to: SOX21 Lysate
- The liver is known to play a pivotal role in modulating blood glucose homeostasis through intrahepatic glucose metabolism. Here, we reveal a unique mechanism by which fatty liver exacerbates hyperglycemia through remote communication from hepatocytes to intestinal stem cells (ISCs), independent of enhanced intrahepatic gluconeogenesis. Mechanistically, hepatocyte-derived alkaline phosphatase (ALP) targets α2δ-1 in ISCs to promote the membrane translocation of Ca1.2. This process triggers increased intracellular calcium levels, which subsequently activates the calcineurin/NFATC2 signaling axis, thereby inhibiting SOX21 expression. Then, decreased expression of SOX21 downregulated bone morphogenetic protein 7 (BMP7), ultimately hindering ISCs differentiation into intestinal L-cells. Consequently, the levels of hypoglycemic enteroendocrine hormones secreted by L-cells are decreased, thereby promoting hyperglycemia. Therapeutically, inhibiting ALP synthesis in fatty liver independently reduces blood glucose and synergistically enhances the hypoglycemic effect of metformin. Our study highlights the role of liver-gut communication in regulating the fate of ISC differentiation and blood glucose homeostasis. - Source: PubMed
Publication date: 2026/06/17
Ye JinbaoWan QianyiLiu XingzhuDeng YawenZhang ZehongChen HaiouGao ChaoxinZhang ShiyuZhu YuedanYan JinhuaYuan YuChen YiChen Haiyang - Glioblastoma multiforme (GBM) is characterized by its aggressive nature and is the most malignant form of glioma, associated with a poor clinical prognosis. This study aimed to evaluate and predict the survival outcomes of GBM patients by developing a prognostic long non-coding RNA (lncRNA) signaling model for GBM. - Source: PubMed
Publication date: 2026/05/22
Yang YanyanSun JiayaoFang YanShan WeiLi PengfeiMa YaxuanNi Weimin - Glutathione peroxidase (GPx), a key antioxidant enzyme, shows altered activity in individuals with schizophrenia. However, the molecular mechanisms behind this alteration remain incompletely understood. In this study, we combined bioinformatics and experimental approaches to explore potential associations between redox-related long non-coding RNAs (lncRNAs) and GPx activity in schizophrenia. - Source: PubMed
Publication date: 2026/05/26
Khaki MahsaMassoudifar AliDavoodian NahidMousavi PegahDavoodian NajmehMahmoudi Masoumeh - Tooth morphogenesis is controlled by various molecules, and the enamel knot plays a important role as a signaling center. Here, we aimed to analyze the role of AmeloD in the development of the enamel knot. - Source: PubMed
Publication date: 2026/02/12
Oka SaeChiba YutaSato HiroshiChiba MistukiKomine ItaruHirofuji YutaYamada AyaFukumoto Satoshi - The first lineage decision in mammalian development segregates embryonic and extra-embryonic fates, yet the timing of this specification remains under debate. While our previous lineage tracing studies in mice and human suggested that this decision is initiated as early as the 2-cell stage, prevailing models place its onset to the 16-cell stage embryo when the first inside cells form. In mice, we have found that heterogeneous expression of Sox21 at the 4-cell stage contributes to fate specification, with higher SOX21 levels biasing cells toward embryonic fates (future foetus). Here, we investigated whether this heterogeneity originates even earlier. Because conventional single-cell RNA-seq has failed to detect mRNA asymmetries prior to the 4-cell stage, we employed a more sensitive approach, confocal imaging combined with hybridization chain reaction (HCR), to track Sox21 mRNA expression from the zygote through the 4-cell stage. This single-molecule technique revealed pronounced heterogeneity in Sox21 transcript levels as early as the 2-cell stage. Intriguingly, Sox21 mRNA appears to be preferentially expressed from the male pronucleus during minor zygotic genome activation, perhaps as a consequence of H3K27me3 enrichment in the maternal pronuclei and given that haploid parthenogenetic embryos lack SOX21 protein at the 4-cell stage. These findings provide evidence that Sox21 mRNA heterogeneity arises earlier than previously recognized, namely at the 2-cell stage. Our work supports the emerging view that spatial mRNA distribution, long appreciated in non-mammalian embryos, might also contribute to lineage specification in mammals. - Source: PubMed
Publication date: 2026/02/13
Sanchez-Vasquez EstefaniaNawarungruang GydaMeglicki MaciejBronner Marianne EZernicka-Goetz Magdalena