CAMK2A (Internal)
- Known as:
- CAMK2A (Internal)
- Catalog number:
- AP08330PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CAMK2A (Internal)
Related genes to: CAMK2A (Internal)
- Gene:
- CAMK2A NIH gene
- Name:
- calcium/calmodulin dependent protein kinase II alpha
- Previous symbol:
- CAMKA
- Synonyms:
- KIAA0968, CaMKIINalpha
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2016-04-06
Related products to: CAMK2A (Internal)
(I) LightCycler 1. 0; (Internal Control can't be used for this system) ; (II) LightCycler2. 0; (III) PE5700, MJ_Opticon etc. single color systems; (IV) ABI7000, ABI7300, ABI7500, ABI7900, ABI StepO1.0ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Cryogenic Vial,Self-Standing, Internal Thread1.2ml Self-Standing Cryovial Internal Thread w per O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w per Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w per Washer Seal1.2ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w/ Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w/ Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w/Washer Seal1.2ml Self-Standing Cryovial Internal Thread w/Washer Seal1.2ml Self-Standing Cryovial Internal Thread w_ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w_ Silicone Wa1.5-times expansion model of ear dissection, external, middle & internal ear, 4 parts Related articles to: CAMK2A (Internal)
- Compared to lean pig genotypes, the local Krškopolje pig is characterised by a greater capacity for lipid and lower capacity for protein deposition, along with lower dietary protein requirements. The aim of the present study was to unravel the transcriptomic differences in subcutaneous adipose tissue between the local Krškopolje pig and modern hybrids, as well as to study the impact of the reduced protein diet in both genotypes. Differential gene expression analysis between local and modern pigs revealed 375 differentially expressed genes, with 189 upregulated and 186 downregulated in Krškopolje pig. Among the upregulated genes, several suggested more pronounced adipogenesis (SLC7A10, ADIRF, INHBB, and SFRP2) in the Krškopolje pig. In addition, genes encoding collagen proteins and extracellular matrix remodelling (e.g., COL6A5, COL4A5, COL2A1), calcium signalling (TRPV4, CAMK2A, CALML5), pro-inflammatory cytokines (e.g., IL1A, TNFSF9, CXCL8, PTGS2 etc.) and cholesterol metabolism (CYP1A1, CYP2A19, CES1 etc.) were differentially expressed. The reduced protein diet induced only minor changes in gene expression at the individual gene level. However, gene set enrichment analysis revealed that, in Krškopolje pigs, dietary effects were associated with biological processes related to immune response, intracellular protein transport, and extracellular matrix organisation. In the case of modern hybrids, a reduced protein diet resulted in enrichment of gene sets related to oxidative phosphorylation, mitochondrial function, and energy metabolism. In conclusion, this study demonstrated that the adipose tissue of Krškopolje pigs compared with modern hybrids exhibited greater adipogenic potential, being also supported by higher expression of genes involved in extracellular matrix remodelling and inflammation. The impact of a reduced protein diet on adipose-tissue gene expression was relatively small in both breeds, particularly in Krškopolje pig, suggesting a metabolic adaptability of this breed. - Source: PubMed
Publication date: 2026/05/27
Poklukar KČandek-Potokar MSavić BŠkrlep M - Calcium/calmodulin-dependent protein kinase IIα (CAMK2A) is a ubiquitous mediator of Ca²⁺ signal transduction, implicated in the regulation of tumor cell proliferation and differentiation. However, its role and underlying mechanism in glioma remain unclear. In this study, CAMK2A gene expression was analyzed through various glioma-related databases, and confirmed by RT qPCR and Western blotting. Compared with normal brain tissue, CAMK2A expression in glioma tissue was significantly downregulated, with expression levels progressively decreasing as tumor grade increased. Kaplan-Meier survival analysis revealed a significant correlation between low CAMK2A expression and shorter overall survival in glioma patients. The correlation analysis of CAMK2A expression with clinicopathological characteristics revealed that low expression of CAMK2A was significantly associated with tumor recurrence, high pathological grade, TMZ treated, IDH wild-type status, and 1p19q non-codeletion. Enrichment analysis indicated that in the low CAMK2A expression group, biological functions related to calcium signaling pathway, neuroactive ligand-receptor interaction and long-term potentiation were activated. The correlation analysis of CAMK2A expression with the immune microenvironment revealed that the expression level of CAMK2A influenced the immune activity of the TME. CAMK2A expression was negatively correlated with the immune score. Additionally, CAMK2A expression was correlated with multiple immune checkpoint molecules. A significant negative correlation was also observed between CAMK2A expression and TMB. Furthermore, there were associations with Macrophages M0, Plasma cells, T cells regulatory, Dendritic cells activated and T cells gamma delta. All immunobiological functions in the CAMK2A low-expression group were significantly upregulated. Functional CCK-8 assays confirmed that overexpression of CAMK2A inhibited the proliferation of glioma cells, whereas CAMK2A gene knockout produced the opposite effect. Additionally, we discovered that CAMK2A regulates glioma cell proliferation by inhibiting the Ras/Raf/MEK/ERK pathway. In summary, our findings support the notion that CAMK2A is low expressed in gliomas, and this low expression is closely associated with poor prognosis and the immune microenvironment of gliomas. CAMK2A regulates glioma cell proliferation through the Ras/Raf/MEK/ERK signaling pathway. CAMK2A is a potentially important target for glioma therapy. - Source: PubMed
Publication date: 2026/06/25
Sun ZhiminZhang JiaminJin QianxuZhang AoboYao ZhigangZhao ZongmaoMa ZhizhaoHu Jie - Gastric cancer (GC) remains a major global health challenge, characterized by poor outcomes driven by an immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs), particularly the M2 subtype, are central mediators of immune evasion and therapeutic resistance. While tumor-derived exosomes are key regulators of intercellular communication, the mechanisms by which they modulate TAM fate remain unclear. - Source: PubMed
Publication date: 2026/05/18
Chen ZetianHuang HongxinShen YikaiYamamoto MasamiTsukamoto TetsuyaNomura SachiyoJiang TianluXu ZekuanLi Zheng - Heterozygous de novo variants in the transcription factor Activity-Dependent Neuroprotective Protein (ADNP) cause a severe neurodevelopmental disorder, termed Helsmoortel-Van der Aa syndrome (HVDAS), characterised by autism, intellectual disability, and multisystem involvement. The ADNP gene is essential for embryonic development and interacts with components of several chromatin remodelling complexes. However, the precise pathophysiological mechanisms underlying the disorder remain incompletely understood. - Source: PubMed
Publication date: 2026/05/28
D'Incal Claudio PeterCappuyns ElisaPaldi Floravan der Lei Mathijs BAnnear Dale JohnAlastruey Clara MiliánSokolova DimitraElinck EllenDe Man KevinKonings AnthonyHuyghebaert JolienThys SofiePintelon IsabelVerschuuren MarliesCalus ElkeVan Dam DebbyDe Deyn Peter PNguyen SylvieYalcin BinnazHorii TakuroHatada IzuhoMateiu LigiaCavalli GiacomoPasciuto EmanuelaBerghe Wim VandenKooy R Frank - High-altitude hypoxic adaptation in mammals involves complex molecular mechanisms, with non-coding RNAs (ncRNAs) increasingly reported to participate in hypoxia-related regulation. However, the contribution of circRNAs in cardiac adaptation to chronic hypoxia remains largely unexplored. This study performed an integrative competitive endogenous RNA (ceRNA) analysis to investigate circRNA-mediated regulatory networks in the hearts of Tibetan pigs and Yorkshire pigs maintained under high- and low-altitude conditions, using four comparison groups (TH, TL, YH, and YL). Using Ribo-Zero RNA sequencing, we identified 961 circRNAs in heart tissues, with 358 differentially expressed circRNAs (DE-circRNAs) detected across the four groups. Functional enrichment analysis revealed that their host genes were associated with hypoxia-related pathways, including HIF-1, VEGF, AMPK, and autophagy, critical for energy metabolism and mitochondrial function. A HIF-1-specific ceRNA network was constructed, identifying key axes including circDUSP16-ssc-miR-671-5p-, circTLK1-ssc-miR-331-3p-, and circTLK1-novel-miR-624-. JASPAR analysis predicted potential HIF-1α binding sites in the promoters of , , and , supporting their regulatory roles. These findings provide a transcriptomic overview of circRNA expression patterns in pig heart tissues under different altitude conditions and prioritize candidate ceRNA relationships for further functional investigation. - Source: PubMed
Publication date: 2026/05/14
Li PanCheng WeiShang PengTao ZhuZhang HaoZhang Bo