S100A9 _ Calgranulin_B _ MRP14
- Known as:
- S100A9 _ Calgranulin_B _ MRP14
- Catalog number:
- AM00821PU-N
- Product Quantity:
- 10 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- S100A9 _ Calgranulin_B MRP14
Related genes to: S100A9 _ Calgranulin_B _ MRP14
- Gene:
- S100A9 NIH gene
- Name:
- S100 calcium binding protein A9
- Previous symbol:
- CAGB, CFAG
- Synonyms:
- P14, MIF, NIF, LIAG, MRP14, MAC387, 60B8AG, CGLB
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2018-05-02
Related products to: S100A9 _ Calgranulin_B _ MRP14
Related articles to: S100A9 _ Calgranulin_B _ MRP14
- Gouty arthritis (GA) has long been considered a disease primarily driven by innate immune activation, whereas the contribution of adaptive immune remodeling remains incompletely understood. - Source: PubMed
Publication date: 2026/05/26
Zhang PengZhu FangjieXiao YuntingShen ZhengdongFan ChunxiaoKe PeifengXu YaoZhan ChenguangLi XinWu XiaodongMei LiyanGao KaixinDu HaifangChen XiuminJiao YangHuang RunyueWang Maojie - Cigarette smoking (CS) is a major risk factor for cardiovascular disease through chronic inflammation. While its pulmonary effects are well established, the mechanisms linking lung inflammation to vascular injury remain unclear. Because neutrophils are early responders to CS-induced inflammation, we hypothesized that they drive systemic myelopoiesis and vascular inflammation via alarmin release. - Source: PubMed
Publication date: 2026/06/10
Chattopadhyay DipanjanNitin NitinJaggers Robert MAthmanathan BaskaranMaremanda Krishna PKanuri BabunageswararaoDahdah AlbertShukla RajnikantLee Man S KMurphy Andrew JNagareddy Prabhakara R - Heart failure with preserved ejection fraction (HFpEF) has emerged as one of the most challenging public health issues worldwide, with few effective preventive and therapeutic options available. S100A8/A9 is an inflammatory mediator that contributes to the development of several cardiovascular diseases via the TLR4/NF-κB pathway. This study aimed to investigate the role of S100A8/A9 in HFpEF and unravel potential mechanisms. - Source: PubMed
Li YansongHan QiLiu XianlingWang KaiXu DiLu Miao - Renal fibrosis, a pivotal pathological process in chronic kidney disease (CKD), is closely associated with inflammatory responses and gut microbiota dysbiosis. Curcumin (CUR), a natural polyphenol derived from turmeric, shows anti-inflammatory and microbiota-modulating properties. However, its potential to attenuate renal fibrosis via gut microbiota-derived metabolites remains unclear. In this study, we investigated the mechanisms underlying the renoprotective effects of CUR, using a murine model of unilateral ureteral obstruction and LPS-stimulated bone marrow-derived macrophages (BMDMs). CUR treatment significantly alleviated renal interstitial fibrosis, reduced collagen deposition, and downregulated the pro-inflammatory mediators S100 calcium-binding proteins A8 (S100A8)/A9. Additionally, CUR modified the gut microbiota composition by enriching short-chain fatty acid (SCFA)-producing bacteria, leading to elevated systemic SCFA levels, particularly acetate, whose supplementation also ameliorated renal fibrosis, suppressed the S100A8/A9-toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF‑κB) signaling axis, and inhibited macrophage-myofibroblast transition (MMT). Acetate in vitro treatment attenuated the LPS-induced co-expression of S100A8/A9 and TLR4 in BMDMs, reduced pro-inflammatory cytokine release, and suppressed M1 polarization. These findings highlight that acetate, a key microbiota-derived metabolite increased by CUR treatment, mediates renal protection by targeting the S100A8/A9-TLR4 signaling pathway in macrophages, suggesting a novel gut-kidney axis-based therapeutic strategy for CKD. - Source: PubMed
Li ChengChen XulongZha WeiweiShen JiangwenLai JunZheng BingxuanLi LinJiang HongliTian PuXun - Triple-negative breast cancer (TNBC) harbors an immunosuppressive tumor microenvironment dominated by tumor-associated macrophages (TAMs). P2RY6, a UDP-sensitive purinergic receptor, is implicated in immune modulation, but its functional role in TNBC TAMs remains elusive. - Source: PubMed
Publication date: 2026/06/06
Wang XinMa MingyueZhang MingyuLu HanLiu YingZhou YangHan Bing