CAMK2A pThr286
- Known as:
- CAMK2A pThr286
- Catalog number:
- 56370-25
- Product Quantity:
- 25 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CAMK2A pThr286
Related genes to: CAMK2A pThr286
- Gene:
- CAMK2A NIH gene
- Name:
- calcium/calmodulin dependent protein kinase II alpha
- Previous symbol:
- CAMKA
- Synonyms:
- KIAA0968, CaMKIINalpha
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2016-04-06
Related products to: CAMK2A pThr286
Related articles to: CAMK2A pThr286
- Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba is a traditional Tibetan medicine that has long been used in China for its cardioprotective, Qi-tonifying, and mind-calming properties. It is traditionally indicated for conditions such as irritability, restlessness, and agitation. Among its major active constituents are two naturally occurring small-molecule phenols-salidroside (SAL) and its aglycone tyrosol (TYR). While SAL has been reported to exert neuropsychiatric effects including anxiolytic activity, the underlying mechanisms remain incompletely understood, and whether TYR shares similar anxiolytic properties has yet to be clarified. - Source: PubMed
Publication date: 2026/08/19
Cui JunboJia ChunxueWang ZixinSun YuhanLiang YuluLiu ChuanxinHuang Jianmei - The excessive hierarchical follicles (EHF) trait is a form of ovarian dysfunction in poultry, characterized by an accumulation of hierarchical follicles; however, the developmental dynamics and epigenetic mechanisms underlying this trait remain incompletely understood. In this study, ultrasonography was applied to monitor follicle development dynamics in chickens. Furthermore, whole-genome bisulfite sequencing was performed to identify DNA methylation alterations in the granulosa layer relevant to the EHF trait. During the early laying period, the EHF trait exhibited a fluctuating downward trend and was associated with impaired egg production. DNA methylation occurred predominantly in the CG context and displayed a pattern of promoter hypomethylation and genebody hypermethylation. In EHF chickens, more pronounced hypomethylation was detected in CpG islands, promoters, 5'UTRs, and exons in the small yellow follicle granulosa layer (SYG). Several genes overlapping promoter-related differentially methylated regions were significantly enriched in pathways such as Wnt signaling, Calcium signaling, and Focal adhesion. Among these genes, AKT1, PIK3CA, FZD2, CAMK2A, and RYR2 exhibited significant promoter hypomethylation together with increased mRNA expression. In summary, this study suggests that region-specific promoter hypomethylation in SYG may contribute to EHF development. These findings enhance understanding of the epigenetic regulation of the EHF trait and may support efforts in laying management. - Source: PubMed
Publication date: 2026/05/22
Xu ZihanPan YanyueZhu RanranJiang YuxiangLian ZiyiZhang BingjieTang HaonanXiong WanyiWang XiupingWang JiankuiDeng Xuemei - Colorectal cancer (CRC) remains a leading cause of cancer mortality, and the molecular drivers of progression and distant metastasis are incompletely understood. By integrating differential expression and survival analyses of TCGA CRC cohorts with HOX family genes, we identified HOXC11 as a key metastasis-associated factor. HOXC11 was markedly upregulated in CRC tissues and cell lines, with higher expression in metastatic lesions than in primary tumors, and elevated HOXC11 correlated with poor patient prognosis. HOXC11 functionally increased CRC cell proliferation, migration, and invasion in vitro and facilitated tumor growth and metastasis in vivo. Mechanistically, HOXC11 directly bound to the CAMK2A promoter and transactivated CAMK2A, leading to increased phosphorylated CAMK2A and initiation of the NF-κB pathway, which facilitated p65 nuclear translocation and induced CXCL5 expression to drive CRC progression. Conversely, CXCL5 signaling through CXCR2 upregulated HOXC11 via the ERK1/2-SP1 axis, forming a positive feedback loop. Notably, combined inhibition of CAMK2A (KN-93) and CXCR2 (SB265610) significantly attenuated HOXC11-mediated proliferation and metastasis. Collectively, these findings define a HOXC11-CAMK2A-NF-κB-CXCL5 circuit as a potential therapeutic target in CRC. - Source: PubMed
Publication date: 2026/08/19
Sun QingyangXu HengjieYang ShengZhou JiahuiTian ChuanxinNie HongxuJin ChiWang TuoChen ZhihaoTang JunweiFeng YifeiWang XiaoweiSun Yueming - Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous neurodevelopmental condition. Whole‑exome sequencing (WES) is a pivotal diagnostic tool, though its yield varies across populations. This study aimed to determine the diagnostic yield and characterize the genetic spectrum identified by WES in a pediatric ASD cohort from Saudi Arabia. - Source: PubMed
Publication date: 2026/08/17
Alasiri AbdulazizAl-Jabri BasmahAbukhaled MusaedAldhalan HeshamAl Eman NoorAlmogren SaraAlodah NoraAlhamoudi SaadAlyazidi Anas - Chronic exposure to mid-band radiofrequency (RF) electromagnetic fields at 3.5 GHz is increasingly relevant to modern wireless environments; however, its effects on hippocampal circuit stability under non-thermal conditions remain unclear. We investigated whether prolonged 3.5-GHz RF exposure is associated with anxiety-like behavior and hippocampal transcript-level changes consistent with excitatory-inhibitory (E/I) imbalance, and whether thymoquinone (TQ) or taurine (TAU) are associated with modulation of these responses. - Source: PubMed
Publication date: 2026/08/07
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