S100A9, human, recombinant, full length
- Known as:
- S100A9, H. sapiens, Rec., length
- Catalog number:
- 201SA09
- Product Quantity:
- 5x0.5mg
- Category:
- -
- Supplier:
- ProtEra
- Gene target:
- S100A9 human recombinant full length
Related genes to: S100A9, human, recombinant, full length
- Gene:
- S100A9 NIH gene
- Name:
- S100 calcium binding protein A9
- Previous symbol:
- CAGB, CFAG
- Synonyms:
- P14, MIF, NIF, LIAG, MRP14, MAC387, 60B8AG, CGLB
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2018-05-02
Related products to: S100A9, human, recombinant, full length
Related articles to: S100A9, human, recombinant, full length
- C/EBPβ regulates oncogene-induced senescence (OIS) and the senescence-associated secretory phenotype (SASP) through activation by ERK1/2 and CK2. In tumor cells, C/EBPβ activity is suppressed by its 3'UTR via a mechanism termed 3'UTR regulation of protein activity (UPA), which spatially segregates transcripts from kinase-rich perinuclear endosomes. Here, we identify kinase-proximal mRNA decay as the underlying mechanism. The mRNA decay factors UPF1 and STAU1/2 localize to perinuclear endosomes and promote degradation of transcripts, thereby preventing C/EBPβ phosphorylation and activation. Disruption of this pathway restores C/EBPβ activity and induces senescence. , deletion of a G/U-rich regulatory element (GRE) in the 3'UTR impairs the progression of Kras-driven lung tumors and biases cells toward an AT2-like differentiation state with reduced EMT-associated transcriptional reprogramming. RAS-expressing fibroblasts show enhanced OIS that requires upregulation of the pro-senescent cytokine S100a9. These findings identify perinuclear mRNA decay as a mechanism suppressing C/EBPβ activity and senescence in cancer. - Source: PubMed
Publication date: 2026/08/04
Salotti JacquelineAsif NidaBasu SrikantaDas AniruddhaHu LinshanYang MeiKarim BaktiarSaylor KarenMartin NancyScheiblin David AMisra SwetaLuke Brian TAndresson ThorkellYi MingGalloux MélissaLockett StephenTessarollo LinoJohnson Peter F - Diabetic foot ulcer (DFU) affects approximately 25% of diabetic patients and represents the leading cause of non-traumatic lower extremity amputation. Neutrophil extracellular traps (NETs) contribute to chronic inflammation; however, their mechanistic role in DFU healing failure remains incompletely characterized. This study integrated bulk RNA sequencing (GSE143735, n = 9) and single-cell RNA sequencing (scRNA-seq; GSE165816, n = 11) datasets to investigate NET-related transcriptional programs. Differential expression analysis identified 96 differentially expressed genes, with significant NET pathway enrichment in non-healers (normalized enrichment score = 4.35, false discovery rate q < 0.001). Analysis of 33,654 single cells revealed elevated NET activity scores in neutrophils from non-healing wounds ( = 4.73 × 10). Four neutrophil subpopulations were identified, with the NETs-high subset expanded in non-healers (43.1% versus 15.4%). Cell-cell communication analysis demonstrated enhanced S100A8/A9-RAGE and IL1B-IL1R signaling in the non-healing state. A six-gene signature (S100A8, S100A9, MPO, ELANE, NCF1, HMGB1) achieved an area under the receiver operating characteristic curve of 0.750 for healing prediction under leave-one-out cross-validation. These findings implicate NET pathway activation as a potential driver of DFU healing impairment and identify candidate prognostic biomarkers warranting prospective validation. - Source: PubMed
Publication date: 2026/07/27
Li DazhiGu HaoyuXia ShiboYuan LiangxiBao JunminLu Qingsheng - Increased S100 calcium-binding protein A9 (S100A9)-related signals have been reported in selected hepatic and ocular inflammatory settings. This structured narrative review evaluates S100A9-related species as candidate participants in hepato-ocular crosstalk. Across human, ocular fluid, animal, and cellular studies, the available findings provide context-specific support for disease-associated hepatic expression and ocular responsiveness, with stronger evidence for selected local S100A9-Toll-like receptor 4 (TLR4)-associated effects than for S100A9-specific receptor for advanced glycation end products (RAGE) signaling. Clinical associations involving metabolic dysfunction-associated steatotic liver disease, diabetic retinopathy, chronic liver disease, dry eye disease, and uveitis are heterogeneous and confounded. Interpretation is further limited by the non-equivalence of S100A9, S100A8/A9, calprotectin, and higher-order complexes. Current evidence, therefore, suggests that S100A9-related species may serve as exploratory indicators of inflammatory activity or contribute to local inflammatory amplification in selected settings, rather than acting as established liver-derived causal signals. Future studies should prioritize analyte-specific measurement, source tracing, and selective perturbation. S100A9 is best regarded as a testable candidate node within a broader metabolic-inflammatory network. - Source: PubMed
Publication date: 2026/08/05
Wang PengLi YameiXia BohouLin YanTuo QinhuiLin LimeiPeng Qiuxian - Inflammatory bowel disease (IBD) and osteoporosis (OP) often co-occur, with IBD accelerating OP onset, though the underlying mechanisms remain unclear. - Source: PubMed
Publication date: 2026/08/12
Su YueLuo XiaohuiXu Haitao - The physicochemical properties of highly diluted homeopathic preparations remain insufficiently characterized. This study investigated particulate features of Kali carbonicum (KCO) at 50-millesimal potencies (LM4-LM7, ~1:50,000 dilutions per step) and explored plasma proteomic changes in a placebo-controlled N-of-1 trial. Scanning electron microscopy showed larger particle size in Kali carbonicum (67.3 nm) than in the lactose control (47.5 nm) at LM4 in a descriptive comparison. Dynamic light scattering showed no significant differences in size, polydispersity, or zeta potential among Kali carbonicum, lactose control, and solvent blank, accounting for vial-level clustering. Atomic force microscopy showed more compact dendritic assemblies in Kali than in lactose controls, suggesting trituration influences self-organization. Raman spectroscopy of LM7 detected carbonate-associated bands absent in controls. Plasma proteomics identified six FDR-significant proteins during Kali exposure, including increased S100A9, with exploratory enrichment for inflammation, cytoskeletal, and motility terms. These findings are exploratory and do not imply causality. - Source: PubMed
Publication date: 2026/08/11
de Matos Dourado Simões Matheusde Sousa Caren Nádia Soaresde Cássia Evangelista de Oliveira FátimaCarlos Juliane Aparecida CrispinDos Santos Nogueira Renande Moura Campos Eugênioda Fonseca Magalhães Patrícia AndréaJúnior Antonio Brazil VianaGomes Raelle Ferreirade Paula Regina Celia MonteiroFreire Rosemayre SouzaLeal Luzia Kalyne Almeida Moreirade Melo Thais NunesSalomão Francisco Carlos Carneiro Soaresde Sousa Felipe Domingosde Farias Allysson AllanMacedo Danielle SAdler Maristela SchiabelAdler Ubiratan CardinalliSanders Lia Lira Olivier