S100B, human, 15N
- Known as:
- S100B, H. sapiens, 15N
- Catalog number:
- 201SB01_N
- Category:
- -
- Supplier:
- ProtEra
- Gene target:
- S100B human 15N
Related genes to: S100B, human, 15N
- Gene:
- S100B NIH gene
- Name:
- S100 calcium binding protein B
- Previous symbol:
- -
- Synonyms:
- S100beta
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-06-27
- Date modifiied:
- 2014-11-18
Related products to: S100B, human, 15N
Related articles to: S100B, human, 15N
- This systematic review and meta-analysis aims to evaluate blood biomarkers associated with neurodegeneration and glial activation, specifically GFAP, NfL, YKL-40, MCP-1, neurogranin, GAP-43, S100B, and NSE, in individuals diagnosed with Alzheimer's Disease (AD). - Source: PubMed
Publication date: 2025/11/14
Ebrahimi RasoulKhozani Amir Abbas Salehi AmniyehMasouri Mohammad MahdiSeifi MojtabaHashempour AnahitaSoltani Sana MohammadNoori Shokoofe - Intracranial aneurysms (IAs) carry a high risk of rupture leading to subarachnoid hemorrhage, yet current diagnostic methods are invasive and costly. This study aimed to evaluate the potential of serum inflammatory markers and cardiotrophin-1 (CT-1) as non-invasive biomarkers for IA presence and rupture risk. - Source: PubMed
Publication date: 2025/11/11
Men WeidongZhang XuehaoZhang LijianSun ShuoWang YatongZhao PengfeiZuo JiaLi ChunhuiShan Xiaosong - Concussions, classified as a type of mild traumatic brain injury (mTBI), are frequently underdiagnosed due to the subjective nature of symptoms and limitations in existing diagnostic methodologies. Current clinical evaluations, including tools such as the Sport Concussion Assessment Tool 5 (SCAT5), Balance Error Scoring System (BESS), and Vestibular Ocular Motor Screening (VOMS), demonstrate high sensitivity and specificity but often fail to capture the full complexity of concussive injuries. Emerging diagnostic approaches, such as blood biomarkers (for example, glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), S100 calcium-binding protein B (S100B), and tau) and advanced neuroimaging techniques (for example, diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI)), show promise but remain impractical for routine clinical use due to accessibility and standardization challenges. This review examines objective markers, including neuroimaging, electrophysiological measures (for example, Electroencephalography (EEG), Magnetoencephalography (MEG)), and real-time diagnostic tools, as complementary strategies to enhance traditional clinical evaluations. Findings indicate that while clinical assessments remain central to concussion diagnosis, integrating them with advanced imaging and electrophysiological tools can provide more accurate diagnostics and recovery tracking. Biomarkers, although not yet ready for widespread use, hold significant potential for future applications. Further research is required to validate these methods and establish standardized protocols to facilitate their integration into clinical practice. - Source: PubMed
Publication date: 2025/10/30
Kamil RobertAtef AbdelAlim YoussefPatel ShivSweeney PaxtonFeng HarryHundal JasdeepGoldstein Ira - Fetal hypoxia remains a major unresolved clinical challenge. Using artificial placenta (AP) technology, we established a standardized model of progressive hypoxia that induces brain injury in fetal sheep. To support the development of new antenatal monitoring strategies, we further profiled gestation-specific physiological, biochemical, protein, and cfRNA responses during progressive hypoxia. Seven fetuses at 123 days gestational age (dGA) and eight fetuses at 98 dGA (term = 150 dGA) were supported on the AP. Following a 12-h stabilization period, during which FiO₂ and gas flow to the AP oxygenator were adjusted to maintain fetal SO₂ at 65-75% and pCO₂ at 35-45 mmHg, both parameters were reduced by 5% every 30 min until termination criteria were met (arterial pH < 7.0 or base excess < -12). This protocol produced 240-300 min of progressive hypoxia. Physiological parameters, blood gases, biochemical markers, and cardiac and vascular ultrasound were assessed hourly. At the end of the experiment, brain histology and plasma cfRNA profiling were performed. Progressive hypoxia induced significant increases in pCO₂ and lactate and decreases in SO₂, CtO₂, pH, and BE in both groups (p < 0.05). Gestation-specific differences were observed in pO₂, glucose, and vital signs (heart rate, mean arterial pressure, and circuit flow). AST, ALT, and NSE rose significantly only at 123 dGA (p < 0.05), whereas S100B and NT-proBNP increased in both groups. Histology confirmed hypoxic brain injury at both gestational ages. In 123 dGA fetuses, iliac artery pulsatility index and heart rate predicted dysregulation of pH, BE, SO₂, and lactate (R = 0.538-0.745, p < 0.05). Plasma cfRNA analysis demonstrated distinct gestation-specific gene expression patterns consistent with hypoxia-induced injury. We developed a standardized, regulable model of fetal hypoxia and demonstrated brain injury accompanied by gestation-specific physiological, biochemical, and transcriptomic responses. Plasma cfRNA profiling highlighted its potential as an antenatal biomarker of hypoxic insult. This platform may facilitate the development of new diagnostic tools and guide evaluation of postnatal interventions. - Source: PubMed
Publication date: 2025/11/13
Usuda HaruoIkeda HideyukiWatanabe ShimpeiJohnson Erin LCarter Sean W DKumagai YusakuSaito YuyaSeah MichelleSesurajan Binny PTakahashi TsukasaMochi NoriyoshiSahara KantarouWatson HannahKawamura ShinichiSaito MasatoshiKemp Matthew W - Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus, characterized by neuroinflammation. Previous studies have shown that dorsal root ganglion (DRG) neurons can regulate microglial polarization. This study aims to investigate how exosomal circ_STAT1-AS from dexmedetomidine (DEX)-treated DRG neurons affects microglial polarization in DPN. - Source: PubMed
Publication date: 2025/11/11
Wei YuZeng XiaolingLi FujunWei ShanshanLi ChunniGan ZhaoyiQin ZhengzhuoLin YingYe MaoyingWei XiongliLi SenlinZhang Yanzhuo