S100A12, human, recombinant, full length, unlabelled
- Known as:
- S100A12, H. sapiens, Rec., length, unlabelled
- Catalog number:
- 201SA12_H
- Category:
- -
- Supplier:
- ProtEra
- Gene target:
- S100A12 human recombinant full length unlabelled
Related genes to: S100A12, human, recombinant, full length, unlabelled
- Gene:
- S100A12 NIH gene
- Name:
- S100 calcium binding protein A12
- Previous symbol:
- -
- Synonyms:
- p6, MRP6, CGRP, CAAF1, CAGC, ENRAGE
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-30
- Date modifiied:
- 2018-05-02
Related products to: S100A12, human, recombinant, full length, unlabelled
Related articles to: S100A12, human, recombinant, full length, unlabelled
- Perioperative neurocognitive disorders (PNDs) are frequent and severe complications in older surgical patients, encompassing postoperative delirium, delayed neurocognitive recovery, postoperative neurocognitive disorder, and long-term cognitive impairment. These complications lead to prolonged hospital stay, elevated medical expenditure, and compromised long-term quality of life. In this 2026 narrative review, we systematically outline up-to-date evidence on the pathophysiology, risk factors, screening approaches, and evidence-based interventions for PNDs. The core mechanisms involve neuroinflammation, gut microbiota dysbiosis, blood-brain barrier disruption, cerebral hypoperfusion, oxidative stress, and tau hyperphosphorylation. Key risk factors include advanced age, preoperative cognitive impairment or frailty, intraoperative hypotension, deep anesthesia, hypothermia, cardiopulmonary bypass, and suboptimal postoperative pain and sleep control. Bedside tools (Mini-Cog, MoCA, MMSE, FRAIL scale) permit feasible risk stratification; tau-PT217, NfL, S100A12, and GFAP are emerging predictive biomarkers. Dexmedetomidine is a pharmacologic agent that has been extensively studied and has relatively strong supporting evidence. Non-pharmacological interventions and multidisciplinary care are recommended as first-line strategies. Outstanding issues include optimal intraoperative hemodynamic and anesthetic thresholds, causal links between delirium and long-term cognitive decline, and clinical validation of biomarkers. Future research demands large-scale multicenter randomized controlled trials and standardized workflows to strengthen personalized perioperative brain protection in elderly surgical patients. - Source: PubMed
Publication date: 2026/07/04
Zhou XingboYang JiaxinTang ZhiyinYang ShengZhao HaiYang Fan - Giant cell arteritis (GCA) is the most prevalent vasculitis in the elderly of Caucasian ancestry, with the risk of visual loss as the most serious complication if the glucocorticoid therapy does not succeed. While imaging and temporal artery biopsy (TAB) remain diagnostic gold standards, new laboratory tests are needed to assess disease activity and follow-up monitoring. - Source: PubMed
Publication date: 2026/07/01
Seidlberger SCastañeda SWietzorrek GFaserl KTriguero-Martínez AGonzález-García ASchirmer MSantos-Sierra S - Despite significant efforts to improve diagnostics, tuberculosis (TB) diagnosis still relies on clinical and laboratory methods limited by cost, expertise, and time. Early diagnosis is essential for effective management of pulmonary TB (PTB), pleural TB (PLTB), and latent TB infection (LTBI), highlighting the urgent need for rapid, accurate, and accessible TB diagnostics based on low-invasive sampling. In this study, a quantitative rapid test, previously evaluated in European and African cohorts, was applied to a Brazilian cohort to measure six host-derived proteins in serum from individuals with PTB, PLTB, other pleural diseases (OPLD), LTBI, and controls. Serum levels of CRP, ferritin, and SAA1/A2 were significantly elevated in PTB and PLTB compared to controls. SAA1/A2 and IP-10 levels were higher in PLTB compared to LTBI. Furthermore, IP-10 serum levels showed diagnostic potential, as they were elevated in PTB compared with both LTBI and controls, and significantly increased in PLTB compared to OPLD. In pleural effusion, IP-10, IL-6, and S100A12 were significantly higher in PLTB than in OPLD, while ferritin levels were higher in OPLD. Our study shows that quantitative detection of host-derived biomarkers identified for active PTB in European and African populations can support clinical decision-making for TB spectrum in a Brazilian setting. - Source: PubMed
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