Clip 3_pk, SA
- Known as:
- Clip 3_pk, SA
- Catalog number:
- 2398203
- Category:
- -
- Supplier:
- Ato
- Gene target:
- Clip 3_pk
Related genes to: Clip 3_pk, SA
- Gene:
- CORO2B NIH gene
- Name:
- coronin 2B
- Previous symbol:
- -
- Synonyms:
- ClipinC, KIAA0925
- Chromosome:
- 15q23
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-19
- Date modifiied:
- 2016-10-05
Related products to: Clip 3_pk, SA
Related articles to: Clip 3_pk, SA
- Obesity-related insulin resistance (IR) involves mitochondrial dysfunction and ferroptosis dysregulation. Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), an epigenetic regulator of DNA methylation, mediates crucial functions in disease progression, though its mechanisms in IR remain unclear. - Source: PubMed
Publication date: 2026/03/31
Deng XuLi XiaopingCai JialuoChen XinyuXu ZelinLuo Yuntao - To investigate the whole-genome differential methylation profile of patients with high-altitude polycythemia (HAPC). - Source: PubMed
Ji Jun-HuaYang MinJiang YanYang Ting-XianMa Xiao-JingYin Qi-ChaoYin Hong-WeiJi Lin-Hua - Lung cancer remains the leading cause of cancer-related deaths worldwide, driven by its complexity and the heterogeneity of its subtypes, which influence pathogenesis, tumor microenvironment, and genetic alterations. We developed a novel weighted gene regulatory network reconstruction method based on maximum entropy and Markov chain entropy principles, which integrates gene expression and DNA methylation data to generate biologically informed networks. Applied to LUAD and LUSC datasets, we define a network methylation index to determine whether gene methylation acts as oncogenic or tumor-suppressive. By revealing a stable core set of pathogenic genes, we identify not only genes with significant expression changes, such as and , but also pathogenic genes with stable expression, such as and . Additionally, we uncover potential driver genes, such as and , associated with disease stage, gender, and smoking status. This method offers a more comprehensive understanding of NSCLC mechanisms, paving the way for improved therapeutic strategies. - Source: PubMed
Publication date: 2025/02/20
He QingcaiMi ZhilongYin ZiqiaoZheng ZhimingGuo Binghui - Colon cancer is a common tumor in the gastrointestinal tract with a poor prognosis. According to research reports, ubiquitin-dependent modification systems have been found to play a crucial role in the development and advancement of different types of malignant tumors, including colon cancer. However, further investigation is required to fully understand the mechanism of ubiquitination in colon cancer. - Source: PubMed
JIang WanjuDong JiaxingZhang WenjiaHuang ZhiyeGuo TaohuaZhang KehuiJiang XiaohuaDu Tao - We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × 10 ). Among these, three were distinct from previously identified loci: rs76072851 in CORO2B gene (15q23), odds ratio (OR) = 1.54, 95% confidence interval (CI), 1.36-1.76, p = 5.30 × 10 ; rs7837051, near two long noncoding RNA (lncRNA) genes, PRNCR1 and PCAT2 (8q24.21), OR = 1.41 (95% CI, 1.31-1.51), p = 8.77 × 10 ; and rs56339048, near an lncRNA gene, CASC8 (8q24.21), OR = 1.25 (95% CI, 1.16-1.35), p = 2.14 × 10 . We refined the lead SNPs for two previously identified SNPs in Taiwanese: rs13255059 (near CASC8), p = 9.02 × 10 , and rs1456315 (inside PRNCR1), p = 4.33 × 10 . We confirmed 35 out of 49 GWAS-identified East Asian PCa susceptibility SNPs. In addition, we identified two SNPs more specific to Taiwanese than East Asians: rs34295433 in LAMC1 (1q25.3) and rs6853490 in PDLIM5 (4q22.3). A weighted genetic risk score (GRS) was developed using the 40 validated SNPs and the area under the receiver-operating characteristic curve for the GRS to predict PCa was 0.67 (95% CI, 0.63-0.71). These identified SNPs provide valuable insights into the molecular mechanisms of prostate carcinogenesis in Taiwan and underscore the significant role of genetic susceptibility in regional differences in PCa incidence. - Source: PubMed
Publication date: 2024/02/23
Bau Da-TianTsai Chia-WenChang Wen-ShinYang Jai-SingLiu Ting-YuanLu Hsing-FangWang Yu-WenTsai Fuu-Jen