Prime MMLV RTase
- Known as:
- Prime MMLV RTase
- Catalog number:
- R-1000
- Product Quantity:
- 10,000 units
- Category:
- -
- Supplier:
- BioBiZ
- Gene target:
- Prime MMLV RTase
Related genes to: Prime MMLV RTase
- Gene:
- QPRT NIH gene
- Name:
- quinolinate phosphoribosyltransferase
- Previous symbol:
- -
- Synonyms:
- QPRTase
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-16
- Date modifiied:
- 2014-11-19
Related products to: Prime MMLV RTase
3 prime Exonuclease Antibody.3 prime Exonuclease Peptide Please note that this peptide has a delivery time of approximately 3 weeks. If the peptide is out of stock, the delivery time may take up to 1-3 months.3'-5' exonuclease TREX1,Bos taurus,Bovine,Three prime repair exonuclease 1,TREX13'-5' exonuclease TREX1,DNase III,Homo sapiens,Human,Three prime repair exonuclease 1,TREX13'-5' exonuclease TREX1,Mouse,Mus musculus,Three prime repair exonuclease 1,Trex13'-5' exonuclease TREX2,Homo sapiens,Human,Three prime repair exonuclease 2,TREX23'-5' exonuclease TREX2,Mouse,Mus musculus,Three prime repair exonuclease 2,Trex25 PRIME HotMasterMix _ 100 Rxns5 PRIME HotMasterMix _ 1000 Rxns5 PRIME MasterMix _ 100 Rxns5 PRIME MasterMix _ 1000 RxnsAmersham ECL Prime Reagent 1000cm2Amersham ECL Prime Reagent 3000cm2anti-CKII alpha prime polypeptideanti-CKII alpha prime polypeptide Related articles to: Prime MMLV RTase
- Breast cancer heterogeneity presents a significant challenge for effective diagnosis and treatment. A deeper understanding of the tumor microenvironment (TME) and its metabolic dynamics is essential for addressing this complexity. This study explored the interplay between TME components and metabolic profiles in breast cancer using RNA sequencing data from both bulk and single-cell analyses. - Source: PubMed
Publication date: 2026/06/22
Huang ZhongLin ShuhuiLiang YingKhan MuhammadChen WeiruiLi XuefengLiu XiaolanWu YunyuYe Jiacai - ELOC-mutated renal cell carcinoma (RCC) is a rare tumor with only ∼40 cases reported to date; it shares a molecular background with clear cell RCC (ccRCC) in terms of hypoxia-inducible factor-alpha (HIF-α) protein accumulation. ELOC-mutated RCC is characterized by prominent leiomyomatous stromal growth and a more indolent clinical course compared with ccRCC. In our previous study, whole-genome sequencing of 102 ccRCC cases identified 5 cases of ELOC-mutated RCC. In the present study, we conducted proteomic and immunohistochemical analyses on up to 13 Japanese ELOC-mutated RCCs, including 8 previously reported cases, to elucidate its distinct molecular mechanisms and identify biomarkers that may be useful in distinguishing ELOC-mutated RCC from ccRCC. Proteomic profiling revealed that molecules, including cytokeratin 7, scinderin (SCIN), and sortilin 1 (SORT1), were significantly overexpressed in ELOC-mutated RCC compared with ccRCC. Notably, SCIN and SORT1 emerged as novel potential diagnostic biomarkers for distinguishing ELOC-mutated RCC from ccRCC. The analysis further suggested that ELOC-mutated RCC relies more on oxidative phosphorylation and less on glycolysis than ccRCC. This metabolic shift may be linked to the relative depletion of NAD+ due to the low expression of NAPRT and QPRT. In addition, we observed geographic variation in the disease frequency among different cohorts, with a higher frequency in Japan. Our findings provide novel insights into the pathogenesis of ELOC-mutated RCC and highlight SCIN and SORT1 as potential supportive biomarkers. - Source: PubMed
Publication date: 2026/07/13
Fukagawa AkihikoArai YasuhitoMaeshima AkikoHama NatsukoTotoki YasushiNakamura HiromiSaito-Adachi MihokoHokazono YukioNakamura EijiroMatsui YoshiyukiAdachi ShungoHamamoto RyujiUshiku TetsuoYachida ShinichiShibata Tatsuhiro - Colorectal cancer (CRC) is characterized by molecular heterogeneity, with -mutated tumors being particularly aggressive and refractory to standard therapies. This study aimed to identify distinctive proteomic signatures associated with the V600E mutation through comparative tumor tissue profiling. Thirty-three tumor tissues were analyzed: 9 -mutated, 14 -mutated, and 10 wild-type (WT). Proteomic profiling was performed on formalin-fixed, paraffin-embedded (FFPE) tissues using bottom-up LC-MS/MS in a data-independent acquisition mode. Protein identification and relative expression were achieved by using DIA-NN label-free analysis. Group differences were evaluated through multiparametric analyses, and Cox proportional hazard models were applied to identify proteins associated with overall survival. -mutated tumors showed distinct proteomic alterations, including overexpression of dipeptidyl peptidase 4 (DPP4) and lysophosphatidylcholine acyltransferase 1 (LPCAT1) alongside the downregulation of quinolinic phosphoribosyltransferase (QPRT) involved in NAD biosynthesis. Pathway analysis revealed the enrichment of protein folding associated with endoplasmic reticulum (ER) stress. Prognostic accuracy improved when tumor genotype was combined with the expression of activator of HSP90 ATPase activity 1 (AHSA1) and thioredoxin domain-containing 5 (TXNDC5), involved in ER-associated protein folding. These findings define a distinctive proteomic signature in -mutated CRC, characterized by dysregulated protein folding associated with ER stress and supporting the development of targeted therapies and more precise prognostic models. - Source: PubMed
Publication date: 2026/06/28
Miolo GianmariaMarus WallyCanil GiovanniInversi AmyPuglisi FabioCorona Giuseppe - Inflammatory bowel disease (IBD) is associated with energy deficiency and perturbed metabolism of the essential amino acid tryptophan (Trp). - Source: PubMed
Wehkamp LinaHarris Danielle M MKim Na-MiAlsaadi Abrar IWu QicongOumari MhmdTaubenheim JanVolk ValeryCredidio GraziellaKoncina EricMukherjee Pranab KTran FlorianMekdoud TaousYu MeipingSievers Laura KPavlidis PolychronisPowell NickWang ShihanFung IvanWaetzig Georg HRousseaux ChristelDesreumaux PierreRieder FlorianLetellier ElisabethWaschina SilvioMeyer Thomas FAdolph TimonD'Haens GeertKaleta ChristophFeuerhake FriedrichVerstockt BramMcReynolds Melanie RRosenstiel PhilipSchreiber StefanAden Konrad - Tertiary lymphoid structures (TLSs) are associated with superior prognosis in breast cancer (BC). TLSs serve as key niches of anti-tumor adaptive immune responses across various malignancies. However, the tumor-intrinsic factors that are associated with TLSs have been largely overlooked in BC. - Source: PubMed
Publication date: 2026/05/07
Li QiaoYang XinWei LanWang XingWang XiaosongChen JunxiaZhao LiuyangWen Siyang