Upper Tank Support Bar, AE_6155
- Known as:
- Upper Tank Support Bar, AE_6155
- Catalog number:
- 2393199
- Category:
- -
- Supplier:
- Ato
- Gene target:
- Upper Tank Support Bar AE_6155
Related genes to: Upper Tank Support Bar, AE_6155
- Gene:
- TANK NIH gene
- Name:
- TRAF family member associated NFKB activator
- Previous symbol:
- TRAF2
- Synonyms:
- I-TRAF
- Chromosome:
- 2q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-12
- Date modifiied:
- 2015-11-19
Related products to: Upper Tank Support Bar, AE_6155
Related articles to: Upper Tank Support Bar, AE_6155
- - Source: PubMed
Publication date: 2026/04/20
Inson Jessamine Gail MSthapit NivaMalla BikashArce Shad Natthew SEnriquez Ma Luisa DAlam Zeba FHaramoto Eiji - The development of efficient adsorbents for water-based adsorption thermal energy storage (ATES) is essential for the large-scale utilization of low-cost and renewable energy, as the performance of these systems highly depends on the choice of adsorbent-water working pair. While metal-organic frameworks (MOFs) have attracted significant attention for thermal energy storage applications, a systematic evaluation of their suitability as adsorbents for water-based ATES remains limited. In this study, we intend to employ high-throughput screening (HTCS) combined with advanced Monte Carlo simulations to systematically screen the experimentally synthesized MOFs included in the novel MOSAEC-DB for the application in our in-house prototype ATES tank. MOSAEC-DB is the most accurate MOFs database, comprising error-free crystal structures and density functional theory (DFT) fitted partial charges. A large number of MOFs are identified that exhibit excellent performance when benchmarked against the current state-of-the-art zeolite materials in a specific application. Based on the performance assessment metrics, including the energy density (), working capacity (Δ), and regenerability (), six top performers are selected for their extraordinary adsorbent-water working-pair performance. These top-listed candidates exhibit outstanding thermal stability above 523.15 K (250 °C), as reported in the corresponding literature. The obtained of the best-performing candidates is over 450 kWh/m, while commonly used Zeolites (13X and 4A) exhibit between 200 and 400 kWh/m, depending on operating conditions. This systematic analysis provides a clear recommendation for the bulk synthesis of these MOFs and their subsequent evaluation in practical, real-world ATES experiments. - Source: PubMed
Publication date: 2026/04/20
Sajid HasnainDuquette JeanMiller Ronald E - The current study aimed to determine the dietary L-arginine requirements of Coho salmon by evaluating key performance indicators, including growth rate, feed efficiency, nitrogen retention, and body composition. A total of 1800 juvenile coho salmon () (initial weight: 0.32 ± 0.01 g) were randomly assigned to six isonitrogenous and isoenergetic dietary treatments containing different L-arginine levels, with three replicates per group (100 fish per 240 L tank) by following a completely randomized design. The L-arginine supplementation levels were 0% (D-1), 0.50% (D-2), 1% (D-3), 1.50% (D-4), 2% (D-5), and 2.50% (D-6) of the feed, resulting in cumulative dietary arginine concentrations of 2.18%, 2.60%, 2.97%, 3.41%, 3.79%, and 4.16% in the feed, respectively. Following a 14-day acclimatization period, the feeding trial was conducted for 84 days. The survival rates were similar across the groups ( > 0.05). However, growth performance parameters, including body weight gain and specific growth rates (SGRs), were increased with dietary arginine levels ( < 0.05). Arginine supplementation of 1% was the best compared with other levels in terms of feed conversion ratio (FCR) ( < 0.05). The group fed on the D-3 level had the highest protein efficiency ratio (1.61 ± 0.03), which differed significantly from D-1 ( < 0.05). Body protein deposition (BPD) was also highest in D-3 (23.93 ± 0.50%), with significant differences between lower and higher dietary L-arginine levels ( < 0.05). Fish in the D-1 and D-2 groups exhibited significantly lower whole-body arginine levels than other treatments. Lysine content was considerably higher in the D-3 and D-4 fed groups, and valine content was significantly higher in the D-3 group than D-1 and D-2 groups ( < 0.05), while other essential amino acid levels remained unaffected ( > 0.05). The quadratic regression analysis revealed that the estimated cumulative total dietary L-arginine requirement for optimal FCR, SGR, BPD, and protein efficiency ratio of coho salmon was 3.29%, 3.19%, 3.33%, and 3.26%, respectively. Based on the findings, dietary supplementation with L-arginine at an optimal level of ~1% significantly enhances growth performance, feed conversion efficiency, protein utilization, and the deposition of essential amino acids, particularly arginine, lysine, and valine, in juvenile salmon. However, supplementation beyond this level yields diminishing benefits, likely due to metabolic saturation or feedback regulation mechanisms. - Source: PubMed
Publication date: 2026/04/17
Yu LeyongRahman AbdurYu HairuiSattanathan GovindhrajanLi LingyaoMushtaq MaidaYounus MuhammadKhan MuhammadAkhtar Muhammad Uzair - Natural killer cells are emerging as promising "off-the-shelf" effectors for cancer immunotherapy, yet expansion of the NK-92 cell line in batch cultivation leads to rapid loss of cytotoxicity concomitant with lactate accumulation. In this study we developed and validated a two-phase manufacturing strategy that decouples cell proliferation from functional recovery in order to obtain an improved final product potency. Our 8-day kinetic survey determined declines in viability, metabolite profiles and cytotoxicity during static batch expansion. Guided by these data, in a 32-run full-factorial design-of-experiments approach we varied fresh cultivation medium proportion, temperature, dissolved oxygen, and recovery duration; partial least squares modeling identified fresh-medium ratio and recovery time as the primary drivers of cytotoxicity restoration. Identified optimal conditions (90% fresh medium, 37.2 °C, 3.7 days recovery) recovered cytotoxicity and maximized cytotoxic capacity. These setpoints were then translated to a 2 L stirred-tank bioreactor, where a fed-batch expansion under controlled pH and lactate levels produced 2.0 × 10 cells, followed by recovery that achieved 43% ± 8% cytotoxicity. This scalable, two-phase paradigm minimizes medium usage and obviates continuous perfusion, offering a potential workflow to increase NK-92 potency and a base for manufacturing high-quality advanced therapy medicinal products. - Source: PubMed
Publication date: 2026/04/02
von Werz ValentinSzarzynski AleksanderHadrbolec MatthiasMattert GregorZigon-Branc SaraKozma BenceDammermann WernerSpadiut Oliver - The physiological impacts of bile acids (BA) conjugation states remain underexplored in aquatic species. This study investigated the effects of supplementing conjugated BA (bile salts [BS]) or non-conjugated BA (free bile acids [FBA]) on the intestinal health of pearl gentian grouper ( ♂ × ♀) fed a high plant-protein diet for 8 weeks. A total of 300 healthy juveniles (approximately 90-d-old; initial body weight 15.21 ± 0.04 g) were randomly distributed into four dietary groups in triplicate (25 fish per tank): CD group (a fishmeal-based control diet [CD]), PD group (a plant protein-based diet [PD], with 50% fishmeal replaced by cottonseed protein concentrate), BS group (PD supplemented with 0.09% BS), and FBA group (PD supplemented with 0.09% FBA). Compared to the CD group, the PD group significantly impaired growth performance (final body weight and weight gain rate), gut morphology (muscle thickness, plica height, and width), and induced inflammatory response, oxidative stress, endoplasmic reticulum stress, cell apoptosis, and dysregulated amino acid metabolism ( < 0.05). The BS supplementation reversed these adverse effects: it improved final body weight, intestinal morphology, enhanced amino acid transport gene expression, and reduced pro-inflammatory and pro-apoptotic signals ( < 0.05). Transcriptomic analysis revealed that BS shifted the intestinal gene expression profile towards that of the CD group. In contrast, while FBA supplementation showed negligible benefits on most physiological parameters, it did significantly enrich the pathways of "G-protein coupled receptor binding" and "regulation of actin cytoskeleton" ( < 0.05). In conclusion, BS, but not FBA, effectively attenuates intestinal damage and promotes health in groupers fed high plant-protein diets, highlighting the critical importance of BA conjugation in nutritional interventions. - Source: PubMed
Publication date: 2026/03/18
Wang FanBao YuchenZhao YuhuaLai JunxiangYu ErmengJiang FajunXu Jia