CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- BM2047
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Ask about this productRelated genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
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Movaddt AdelaMohsenzadeh-Ledari FaridehOmidvar ShabnamAdib Rad HajarPasha HajarGholinia Hemmatollah - Fricke-xylenol orange (XO)-Pluronic F-127 (FXP) gels have demonstrated favourable dosimetric properties, but their investigation has hitherto been limited to small sample volumes. This study characterised large-volume FXP gel dosimeters combined with optical computed tomography (OCT) readout for three-dimensional 6MV radiotherapy dosimetry measurements. - Source: PubMed
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Grammatikou IoannaPiotrowski MichalPapagiannis PanagiotisStergioula AnastasiaMaras PiotrKozicki MarekPantelis Evaggelos - The FTO rs9939609 risk allele is linked to risk of obesity. Whether causality involves fatty acid (FA) metabolism remains to be fully investigated in adults with obesity. We tested for associations of the risk allele with the FA composition of android and gynoid subcutaneous adipose tissue. We recruited 95 participants with obesity class 2 and 3 and without diabetes, median BMI 42.8 (25th, 75th percentiles: 39.5, 46.5) kg/m2. Participants carried no (TT, n = 33), one (AT, n = 31), or two (AA, n = 31) copies of the FTO risk allele. Biopsies were obtained by aspiration and total FA composition determined by gas chromatography-mass spectrometry (GC-MS). In the cohort overall, there were no significant genotype associations with any single FA. In males with the TT allele, mass of oleic acid (18:1n-9) in the gynoid depot was higher compared with the AT allele when corrected for depot size. We interpret these findings with caution due to the small numbers of males with the TT genotype. Disregarding genotype, in the cohort overall, proportions of saturated FAs were higher, and proportions of monounsaturated FAs lower in android versus gynoid adipose tissue, confirming previous studies. We found previously unreported sex-related differences in FA composition (weight %) and content (weight % corrected for depot mass). Our findings on FTO genotype are generally negative; observations to the contrary require confirmation as does the non-genetic and novel results on sex-related differences. - Source: PubMed
Publication date: 2026/06/17
Mostad Ingrid LøvoldGrill ValdemarSkarra Sisselde Soysa Ann Kristin HjelleFielding Barbara - This study evaluated the effects of five manganese (Mn) sources on Pacific white shrimp (). Five Mn sources include Mn sulfate (MnSO·HO), Mn dioxide (MnO), Mn dioxide nanoparticles (MnONPs), Mn glycine chelate (Mn-Gly), and Mn chelate of hydroxy analogue of methionine (Mn-MHA). During a 56-d feeding trial, 450 shrimp (1.03 ± 0.02 g) were randomly distributed among five dietary treatments, with each having three replicates. No significant differences in growth performance and feed utilisation were found among different Mn sources ( > 0.05). However, organic Mn sources (Mn-Gly and Mn-MHA) significantly enhanced Mn deposition ( = 0.002) and upregulated a key Mn transporter (, , and ) in the hepatopancreas when compared with inorganic MnO source ( < 0.05). Moreover, dietary organic Mn-MHA significantly enhanced systemic antioxidant capacity (total-antioxidant capacity [T-AOC] and glutathione peroxidase [GSH-Px]) and innate immune response, as evidenced by increased activities of relevant enzymes (acid phosphatase [AKP], acid phosphatase [ACP], and nitric oxide synthase [NOS]) and upregulation of associated genes (, , , , and ) when compared with MnO ( < 0.05). Furthermore, the organic Mn sources significantly downregulated genes related to endoplasmic reticulum stress (, , , and ), inflammation (, , and ), and apoptosis (, , and ), while significantly upregulating the anti-apoptotic gene () when compared with MnO ( < 0.05). Notably, Mn-MHA supplementation significantly reduced hepatopancreatic lipid content ( = 0.002) by modulating the expression of genes involved in lipid synthesis ( and ) and lipolysis ( and ) ( < 0.05). In summary, although growth remained unaffected, organic Mn sources, particularly Mn-Gly and Mn-MHA, demonstrated superior bioavailability by enhancing antioxidant status, immune function, and hepatopancreas health as well as by regulating lipid metabolism. - Source: PubMed
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