CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- BM2047
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Type 2 diabetes mellitus (T2D) is the leading cause of end stage renal disease. Screening for chronic kidney disease is recommended for early diagnosis and intervention. This requires assessment of renal function by computing for estimated glomerular filtration rate (eGFR) and urine albumin-creatine ratio. Several formulas have been proposed for computation of eGFR. The European Renal Function Consortium (EKFC) equation, obtained by combining the full age spectrum (FAS) and Chronic Kidney Disease - Epidemiology Collaboration 2021 (CKD-EPI) equations, has been proposed as a more universal formula for eGFR. It has the advantage of eliminating correction for ethnicity and covers a wide age range. The aim of this study is to compare the EKFC and CKD-EPI 2021 equations to assess eGFR among Algerian population with T2D. - Source: PubMed
Publication date: 2026/08/29
Sedoud ZohraBaghdali Feriel YasmineHind ArzourMassinissa OuzriatSabrine DeghimaFarid HaddoumKamel Djenouhat - Insights into how permanent microporosity influences ion transport in polymer electrolytes could facilitate the design of next-generation single-ion conducting (SIC) materials. Intrinsically microporous polymers and conventional polymers are typically regarded as fundamentally distinct electrolyte platforms; direct comparisons between compositionally similar examples are lacking. Here, we introduce a strategy for the synthesis of fluorinated aryl sulfonimide-based polymers of intrinsic microporosity (FAS-PIMs) together with flexible polysulfonimide analogs of similar composition that lack permanent microporosity. Although these polymers possess fundamentally different dry-state architectures, incorporation of a common pore-filling transport medium, succinonitrile (SN), drives the two systems toward remarkably similar nanostructures with similar bulk conductivities (>10-10 S/cm at 40°C-80°C), thermomechanical properties (G' within 1-10 MPa over the temperature range of 25°C-120°C), and reprocessability. Molecular dynamics simulations and experiments suggest these unusual combinations of properties arise through different conduction mechanisms within the materials, and that sulfonimide anions are particularly advantageous for conduction in microporous matrices relative to strongly binding anions. Overall, this work introduces the first sulfonimide-based PIM, establishes a comparison between permanently microporous and transiently porous single-ion conducting polymers, and demonstrates that these two traditionally distinct electrolyte architectures can converge toward similar, useful bulk properties after incorporation of a pore-filling transport medium. - Source: PubMed
Publication date: 2026/09/26
Herzog-Arbeitman AbrahamLeon PabloSchreib Benedikt SJun KyuJungRuza JurgisPerales Vanesa MunozShao-Horn YangGomez-Bombarelli RafaelJohnson Jeremiah A - The fish head contains a large number of bioactive lipids for preparing functional foods. In this study, we analyzed the fatty acid components and molecular species of tilapia head phospholipids (TH-PL), and investigated the preventive effect of them on metabolic syndrome (MS). - Source: PubMed
Publication date: 2026/09/20
Gao XiaYu HuiYi XiangzhouGao ShuxinShen Xuanri - Obesity is a metabolic disorder characterized by excessive lipid accumulation, disrupted fatty acid homeostasis, and gut microbiota dysbiosis. essential oil (ZBO) is a natural plant volatile oil with diverse bioactivities, but its anti-obesity effects and potential associations remain unclear. : HFD-induced obese (DIO) mice were evaluated to determine the effects of ZBO. Physiological parameters, glucose tolerance, and serum biochemical markers were assessed. Potential correlates were explored using a multi-omics approach, including integrated serum untargeted metabolomics, 16S rRNA gene sequencing, and RT-qPCR analysis of key genes involved in lipid metabolism in the liver and white adipose tissue. : ZBO significantly mitigated HFD-induced body weight gain, visceral adiposity, hepatic steatosis, dyslipidemia, and glucose intolerance. Metabolomics indicated that ZBO administration was associated with alterations in the serum metabolic landscape, particularly in pathways related to fatty acid metabolism and AMPK/PPAR-α signaling. Consistently, ZBO treatment was associated with upregulated mRNA expression of lipid-oxidizing genes (AMPK, PPAR-α, CPT1) and downregulated lipogenic genes (SREBP-1c, ACC, FAS, SCD1, LPL). 16S rRNA sequencing suggested that ZBO was associated with increased gut microbial diversity, decreased the Firmicutes/Bacteroidota ratio, and enriched beneficial taxa (e.g., Ligilactobacillus, Alistipes) while suppressing pro-inflammatory genera. Correlation analysis established robust associations between ZBO-modulated microbes and key fatty acid metabolites, particularly acylcarnitines and AMPK/PPAR-α-related intermediates. : Collectively, these multi-omics data suggest that ZBO administration is associated with remodeling of the gut microbiota and correlated changes in fatty acid metabolic pathways. These findings provide preliminary preclinical evidence supporting further investigation of ZBO in the context of dietary strategies for alleviating HFD-induced obesity. - Source: PubMed
Publication date: 2026/09/09
Sun LuchuanyangZhang ShiqiHu HongjuanXu BingbingQian ShanHuang YukunYang XiaoLiang YanChen Xianggui - Stress-induced sebaceous hyperactivity is a key driver of acne and seborrheic dermatitis; however, research investigating the pathway-specific mechanisms through which stress exerts its effects and the suppression of sebum production via targeting stress signaling remains relatively limited. In this study, we investigated whether flower extract (CNF) could counteract stress-induced sebaceous dysfunction and its underlying mechanisms. Using a cortisone-stimulated SZ95 human sebocyte model, we evaluated lipid accumulation, cortisol production, signaling pathway activation, and apoptotic markers. CNF treatment dose-dependently suppressed cortisone-induced lipid production, reducing triglyceride, cholesterol, and free fatty acid levels by up to 35.44%, 38.02%, and 46.39%. Mechanistically, CNF inhibited 11β-HSD1 expression (17.17% reduction) and cortisol secretion (32.84% decrease), thereby blocking local cortisol reactivation. This upstream interception subsequently attenuated PI3K/Akt/mTOR hyperphosphorylation, downregulated lipogenic transcription factors (SREBP-1, PPARγ, LXRα, C/EBP-α) and their target enzymes (FAS, ACC, DGAT). Beyond lipid synthesis inhibition, CNF reversed cortisone-induced apoptosis resistance by reducing the Bcl-2/Bax ratio and suppressing PCNA-mediated hyperproliferation, thereby decreasing sebocyte number. These findings demonstrate that CNF exerts dual oil-control effects: reducing lipid production per cell and reducing lipid-producing cell abundance. Collectively, CNF represents a promising multi-target botanical agent for managing stress-related sebaceous disorders and cosmetic sebum regulation. - Source: PubMed
Publication date: 2026/09/08
Zhang MengFan JiayiQin ZhenyuChen TimsonLi ZhizhenChen YaMa LingWang Guang-LiWang Jing