Alkaline phosphatase _ ALPL
- Known as:
- Alkaline phosphatase _ ALPL
- Catalog number:
- BB-PA1004
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Alkaline phosphatase _ ALPL
Related genes to: Alkaline phosphatase _ ALPL
- Gene:
- ALPL NIH gene
- Name:
- alkaline phosphatase, biomineralization associated
- Previous symbol:
- HOPS
- Synonyms:
- TNSALP, TNALP, TNAP
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-08-08
Related products to: Alkaline phosphatase _ ALPL
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodies Alkaline Phosphatase Conjugated Affinity Purified anti_Swine IgG (H&L) [Goat]1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 900 slides plus (large size1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 350 pl1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 900 plu105 kDa islet cell antigen,BEM-3,Brain-enriched membrane-associated protein tyrosine phosphatase,ICA105,PTP IA-2,PTPLP,Ptprn,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase-like N,R-P12 Lipoxygenase antibody (Alkaline Phosphatase)12 Lipoxygenase antibody (Alkaline Phosphatase)130 kDa myosin-binding subunit of smooth muscle myosin phophatase,Chicken,Gallus gallus,MBS,Myosin phosphatase target subunit 1,Myosin phosphatase-targeting subunit 1,MYPT1,PP1M subunit M110,PPP1R12A,14 kDa phosphohistidine phosphatase,Bos taurus,Bovine,Phosphohistidine phosphatase 1,PHP14,PHPT114 kDa phosphohistidine phosphatase,CGI-202,Homo sapiens,HSPC141,Human,Phosphohistidine phosphatase 1,PHP14,PHPT1,Protein janus-A homolog14 kDa phosphohistidine phosphatase,Mouse,Mus musculus,Phosphohistidine phosphatase 1,Php14,Phpt114 kDa phosphohistidine phosphatase,Oryctolagus cuniculus,Phosphohistidine phosphatase 1,PHP,PHP14,PHPT1,Protein histidine phosphatase,Rabbit14 kDa phosphohistidine phosphatase,Phosphohistidine phosphatase 1,PHP14,PHPT1,Pig,Sus scrofa Related articles to: Alkaline phosphatase _ ALPL
- Hypophosphatasia (HPP) has diverse manifestations overlapping other skeletal and rheumatic disorders. This systematic review assessed frequency of HPP in select and general clinical populations with persistently low alkaline phosphatase (ALP) activity. Undiagnosed HPP was frequently identified. Clinicians should consider HPP for patients with persistently low ALP and hallmark manifestations. - Source: PubMed
Publication date: 2026/10/07
Schäfer Valentin SHinman JessicaMoss KatieCharles Julia FAdachi Jonathan DSinger Andrea JSaraff VrindaDeeb AsmaEzgü Fatih SüheylOtsuka FumioWegmann Liliana-GeorgianaFang ShonaTornero Carolina - To summarize the clinical features, natural history, and ALPL variant spectrum of Chinese children with hypophosphatasia (HPP), and to evaluate diagnostic features across clinical subgroups. - Source: PubMed
Publication date: 2026/09/17
Luo JingjieLiu MinRen XiaoyaLiu MeijuanChen JiajiaWang XinmengYuan ZhengCao BingyanGong Chunxiu - Repair of maxillofacial bone defects presents significant clinical challenges. Orofacial mesenchymal stem cells (OMSCs) mediate maxillofacial bone repair, while the molecular mechanisms governing osteogenic commitment of OMSCs remain incompletely understood. Here, we investigate the function of AF4/FMR2 family member 4 (AFF4) in OMSCs osteogenesis and maxillofacial bone healing. By using a tamoxifen-inducible Aff4 knockout mouse model, we demonstrate that AFF4 depletion significantly delays the alveolar bone repair post-tooth extraction. OMSCs of Aff4 knockout mice exhibit decreased expression of osteogenic markers (RUNX2, ALPL, OSX, COL1A1) and reduced mineralization in vitro. Mechanistically, AFF4 loss suppresses AMPK signalling and downstream mitophagy, manifested by reduced Parkin translocation and LC3B recruitment to mitochondria, and impaired mitophagosome-lysosome fusion. Notably, the rescue of mitophagy and the osteogenic capacity of Aff4-deficient OMSCs by AICAR (an AMPK activator) was abolished by Compound C (an AMPK inhibitor). Collectively, our findings establish the critical role of AFF4 in maxillofacial bone regeneration and demonstrate that it functions through the AMPK-mitophagy axis in OMSCs. This study provides a novel insight into the function of AFF4 in maxillofacial bone biology. - Source: PubMed
Publication date: 2026/09/29
Zhu LiChen ShuoLuo GuowenZhang TingyueLin HengyiChen YilingZhou ChenchenZou Shujuan - Hypophosphatasia (HPP) is a rare metabolic bone disease caused by pathogenic variants in ALPL gene. Due to its marked phenotypic heterogeneity, milder pediatric forms are frequently underdiagnosed, and systematic, laboratory-based screening strategies remain poorly defined. - Source: PubMed
Publication date: 2026/09/30
Zhang DandanWang XueqianZhou LijunLi QunfeiWu HaiyingYang BingyuXie RongrongWang FengyunChen XiuliChen LinqiLi YaoshuangWang QingWang XiaoyanSun HuiWang HongyingHuang JieRen XiuzhiZhang ZhenLinChen Ting - Hypophosphatasia (HPP) is a rare metabolic disorder caused by mutations in the gene leading to tissue-nonspecific alkaline phosphatase (TNSALP) deficiency. Although traditionally considered a skeletal disease, emerging evidence suggests an immunomodulatory role for TNSALP in systemic inflammation and immune-mediated inflammatory diseases (IMIDs). This study investigated clinical, biochemical, and immunological features associated with inflammation in HPP. - Source: PubMed
Publication date: 2026/09/14
Martínez-Heredia LuisMuñoz-Torres ManuelGonzález-Cejudo TrinidadLópez-Robles María DoloresCabeo MónicaCarazo-Gallego ÁngelGarcía-Recio EnriqueGonzález-Salvatierra SheilaContreras-Bolívar VictoriaAndreo-López María CarmenIglesias-Baena IvánAndújar-Vera FranciscoGarcía-Fontana CristinaGarcía-Fontana Beatriz