HLA_DQ (human) _ Clone FN81
- Known as:
- HLA_DQ (H. sapiens) _ Clone FN81
- Catalog number:
- T-1360.0100
- Product Quantity:
- 100ìg
- Category:
- -
- Supplier:
- New Immunology
- Gene target:
- HLA_DQ (human) _ Clone FN81
Related products to: HLA_DQ (human) _ Clone FN81
Related articles to: HLA_DQ (human) _ Clone FN81
- Tacrolimus (Tac or FK-506) is an immunosuppressive agent that inhibits T-cell activation and proliferation. It has a narrow therapeutic index and shows inter-patient variabilities in its plasma concentration. Human Leucocyte Antigen (HLA) plays a major role in immune regulation and function. Tac inhibits the T-cells, and HLA antigens are expressed in T-cells. The objective of this study was to determine the role of the HLA Class I (HLA-A, HLA-B, and HLA-C) and Class II (HLA-DRB1, HLA-DQB1, and HLA-DQA1) in influencing Tac PK among renal transplant patients. - Source: PubMed
Hemani Rashmi JJoreja Amit SShete Nitiraj BSrivastava RatikaSoni Shailesh MGang Shishir DKonnur Abhijit MHegde Umapati NPatel Hardik BMukhopadhyay Banibrata NRaval Manan APandey Sachchida Nand - Celiac disease (CD) risk conferred by HLA-DQ2 and DQ8 varies significantly across populations. In north India, where CD is as prevalent as in European populations, reports on the association of HLA-DQ2 and DQ8 with CD are limited. In a north Indian CD case-control cohort (459 CD and 450 controls), known CD-associated risk HLA-DQ alleles, HLA-DQA1*05:01/02:01/03:01 and HLA-DQB1*02/*03:02, were genotyped using SSP-PCR to uncover their frequency and association with CD. Published dense Illumina_Immunochip genotyping data of the study cohort were used to identify proxy-SNPs for HLA-DQ genotypes and their alleles. We also investigated the correlation between common CD phenotypes and DQ2/8 genotypes. Ninety-nine percent of the CD patients were found to carry HLA-DQ2.5, DQ2.2 or 8. HLA-DQA1*05:01 (OR = 5.86 [4.39-7.81], p < 0.0001) and HLA-DQB1*02 (OR = 16.61 [11.37-24.25], p < 0.0001) were identified as the strongest susceptibility alleles. HLA-DQ2.5 was present in 92% of patients and conferred the highest CD risk (OR = 29.01 [19.56-43.00], p < 0.00001), while DQ8 appeared protective (OR = 0.42 [0.25-0.70], p < 0.0001). HLA-DQ2.5/8 and HLA-DQ2.5/2.2 were found significantly associated with serum anti-tTG-IgA and skin conditions, respectively, among CD patients. rs1129740, rs9273012 and rs7744001 were identified as proxy-SNPs to efficiently predict the presence/absence of DQ2.5, DQ2.2, DQ8 and its alleles. This was the first well-powered study to evaluate the susceptibility of HLA-DQ in CD among the north Indian population. HLA-DQ2.5 showed a strong association with CD, conferring a higher disease risk, while DQ8 appeared protective, and the contribution of DQ2.2 was inconclusive. Three proxy-SNPs, rs1129740, rs9273012 and rs7744001, could be utilized to predict HLA-DQ genotypes as a cost-effective alternative for CD risk assessment. - Source: PubMed
Publication date: 2026/03/08
Tiwari PriyankaThelma B KSood AjitMidha VandanaSenapati Sabyasachi - Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are no current reliable predictors of therapy response at initial clinical presentation. - Source: PubMed
Publication date: 2026/02/24
Tu TiffanyOchoa AlejandroSood AmikaDabrik AshleyChryst-Stangl MeganLane BrandonWu GuanghongDonovan FrankHarper UrsulaChandrasekharappa SettaraEsezobor ChristopherSolarin AdaobiHooper DavidSethna ChristineAmaral SandraKallash MahmoudRheault MichelleVerghese PriyaDharnidharka VikasSalmon EloiseWeng PatriciaSrivastava TarakSeifert Michael EPruette CozumelSelewski DavidGibson KeishaHunley TracyAbeyagunawardena AsiriThalgahagoda ShenalBagga ArvindSinha AditiWebb NicholasGreenbaum LarryGharavi AliKiryluk KrzysztofKretzler MatthiasGuay-Woodford LisaSanna-Cherchi SimoneBierzynska AgnieszkaKoziell AniaWelsh GavinSaleem MoinRotimi CharlesChambers EileenChan Cliburn Jackson AnnetteAdeyemo AdebowaleGbadegesin Rasheed - Anti-interferon-γ autoantibodies (AIGAs) immunodeficiency syndrome is an emerging adult-onset immunodeficiency causing opportunistic infections. However, its comprehensive immune landscape remains elusive. This study presents the first single-cell RNA sequencing (scRNA-seq) analysis of AIGAs immunodeficiency syndrome, aiming to delineate its pathogenic mechanisms. - Source: PubMed
Publication date: 2026/02/03
Liang Si-QiaoHuang Xue-MeiLiang Xiao-NaWu Si-YaoHong Li-MeiChen NiLuo Zeng-TaoNing YanWang Meng-ChanHe Zhi-Yi - This letter to the editor highlights the importance of considering potential cumulative contributions among human leukocyte antigen (HLA) alleles in shaping the clinical manifestations of primary biliary cholangitis. Complementing the overview by Curto , which focused on non-HLA candidate genes, this paper emphasizes that specific haplotypes of , , and , as well as HLA-G*01:01:01:08/UTR-1, may modulate disease heterogeneity, predisposition to primary biliary cholangitis and autoimmune hepatitis overlap syndrome, disease progression, and poorer therapeutic response. A comprehensive understanding of these HLA polymorphisms and their interactive effects is essential for improving risk stratification and guiding personalized management of this complex autoimmune liver disease. - Source: PubMed
Bouayad Abdellatif