CD106 (human) _ Clone 1299_27_1
- Known as:
- CD106 (H. sapiens) _ Clone 1299_27_1
- Catalog number:
- T-1126.0200
- Product Quantity:
- 200ìg
- Category:
- -
- Supplier:
- New Immunology
- Gene target:
- CD106 (human) _ Clone 1299_27_1
Related genes to: CD106 (human) _ Clone 1299_27_1
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: CD106 (human) _ Clone 1299_27_1
Related articles to: CD106 (human) _ Clone 1299_27_1
- Acute lung injury (ALI) is a common critical respiratory illness. 3'-Hydroxypuerarin (3HP), a beneficial isoflavone from (Willd.) Ohwi, possesses significant pharmacological activities, but its effects on ALI remain limited. - Source: PubMed
Publication date: 2026/03/31
Hu HuiyuWang KongyanQiu YiXu ZaibinChen YanHu YingjieHuang JiawenLuo Zhuohui - Cardiovascular diseases (CVDs) remain a major global health issue, with atherosclerosis being a primary driver of their development. Atherosclerosis is driven by oxidative stress, chronic inflammation, and lipid dysregulation, which ultimately lead to endothelial dysfunction and plaque formation. Resveratrol, a polyphenolic compound found in grapes and red wine, has emerged as a promising therapeutic agent due to its multivalent protective effects against atherosclerosis. This review outlines the role of resveratrol in the inhibition of key pathologic processes, including suppression of pro-inflammatory signaling pathways, enhancement of antioxidant defense mechanisms, and regulation of cholesterol homeostasis. Resveratrol inhibits NF-κB activation, resulting in decreased vascular inflammation and reduced expression of adhesion molecules such as Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Cell Adhesion Molecule-1 (ICAM-1), thereby preventing infiltration of immune cells into arterial vessels. Additionally, it increases cholesterol efflux by promoting ATP-binding cassette transporters (ABCA1), enhancing high-density lipoprotein (HDL) function, and lowering lipid levels. Evidence from preclinical and clinical studies suggests that resveratrol holds potential as a natural treatment for the prevention of atherosclerosis. - Source: PubMed
Publication date: 2025/08/30
Moghnieh RazanChahine Mohammad KheirMroweh RiyadChaarani NadimZalzali IssaAbdulaal Saleh-YezanYazbak AmerFarhat HadiKhelo Joy RahebAbdulaal Razan - Atherosclerosis, the leading global cause of death, is a chronic inflammatory vascular disease with higher prevalence and earlier onset in men than in women. This study aims to investigate sex differences in the atherogenic endothelial phenotype during early atherosclerosis processes by providing the first comprehensive analysis of hormone-independent responses in human umbilical vein endothelial cells (HUVECs) from opposite-sex twins. HUVECs underwent pro-inflammatory stimulation with TNF-α and supernatant from activated pro-inflammatory THP-1 cells, revealing distinct sex-specific patterns: mRNA expression of focal adhesion proteins , , , and increased significantly only in male cells, while paxillin showed elevated mRNA and protein levels in both sexes. Male HUVECs exhibited stronger induction of cell adhesion molecule , pro-inflammatory cytokine IL-1β, and proangiogenic factors Flt-3L, G-CSF, and PDGF-AA, whereas IL-22 secretion was exclusively upregulated in female cells. These sex differences in levels of focal adhesion, adhesion molecules, and cytokine profiles uncover the mechanistic backgrounds of the atherogenic endothelial phenotype, independent of systemic hormones. The findings emphasize cellular sex as a critical biological variable in early atherosclerosis and vascular inflammation. - Source: PubMed
Publication date: 2026/03/27
Lorenz MarioPalant RiwkaOscherowa EdithKarmid-Haj Hamoud WeamKirwan Jennifer ATrajkovski SarahWiebach JanineFritsche-Guenther RaphaelaWu HaiyanHaritonow NatalieVietzke AngelikaKaschina ElenaHenrich WolfgangTemp JuliaBarcena Maria Luisa - Cultured urine-derived cells (UDCs) have been proposed as a source of material for the RNA-based molecular diagnosis of genetic disorders. Previous studies have shown that UDCs can be clonally expanded, passaged, frozen, regrown and have some stem cell characteristics, but their anatomic origin and diagnostic utility remain insufficiently explored. In this study, we cultured UDCs from 40 individuals (aged 4 to 20 years; 21 females) and extracted RNA for sequencing. We compared UDC gene expression to that of marker genes of the kidney and urinary tract segments. UDC gene expression most closely matched marker genes of parietal epithelial cells that line the inner surface of Bowman's capsule in the kidney glomerulus. UDCs expressed (CD106) and (OCT4), consistent with a progenitor cell type. UDCs also expressed 54.4% of 3125 OMIM-listed disease-causing genes. This indicated that UDCs can be used to diagnose a similar number of genetic disorders as skin fibroblasts and a wider range of genetic disorders than can be analysed by RNA extracted from whole blood. In conclusion, UDCs are a non-invasive cell source for RNA sequencing that is suitable for investigating a broad range of conditions. - Source: PubMed
Publication date: 2026/03/24
Ludwig KarissaWu ZenghuiBardai GhalibMarulanda JulianaMunns Craig FMoffatt PierreRauch Frank - This study determines the phenotypic and functional characteristics that define distinct fibroblast-like synoviocyte (FLS) populations in rheumatoid arthritis (RA) vs psoriatic arthritis (PsA). - Source: PubMed
Publication date: 2026/04/10
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